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3.4.23.45: memapsin 1

This is an abbreviated version!
For detailed information about memapsin 1, go to the full flat file.

Word Map on EC 3.4.23.45

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

aspartic protease BACE2, BACE 2, BACE-1 homologue, BACE-2, BACE2, beta site APP cleaving enzyme, beta-amyloid precursor protein cleavage enzyme 2, beta-secretase, beta-secretase 2, beta-site Alzheimer's amyloid precurser protein cleaving enzyme 2, beta-site amyloid precursor protein cleaving enzyme 2, beta-site amyloid precursor protein-cleaving enzyme 2, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, down region aspartic protease, DRAP, memapsin-1, memapsin1, membrane aspartic protease of the pepsin family, More, protease ASP1, theta-secretase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.45 memapsin 1

KI Value

KI Value on EC 3.4.23.45 - memapsin 1

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003224
2-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-6-methoxy-1Hbenzo[d]imidazole
-
pH 4.5, 25°C
0.003568
6-fluoro-2-(3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo[d]imidazole
-
pH 4.5, 25°C
0.003081
6-fluoro-2-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo-[d]imidazole
-
pH 4.5, 25°C
0.0000016
Glu-Val-Asn-Leu-(S)-CH(OH)CH2-Ala-Ala-Glu-Phe
-
-
0.000036
Glu-Val-Asn-Leu-CONH-Ala-Ala-Glu-Phe
-
-
0.000001
N'-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl]amino)-1-phenylbutan-2-yl]-N,5-dimethyl-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.0000805
N'-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl]amino)-1-phenylbutan-2-yl]-N-methyl-5-[methyl(methylsulfonyl)amino]-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.000038
N'-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxohexan-2-yl]amino)-1-phenylbutan-2-yl]-N,5-dimethyl-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.000031
N'-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxohexan-2-yl]amino)-1-phenylbutan-2-yl]-N-methyl-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.00001402
N'-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-N,5-dimethyl-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.0001828
N-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl]amino)-1-phenylbutan-2-yl]-5-methyl-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.0000146
N-[(2S,3R)-3-hydroxy-4-([(2S,3S)-3-hydroxy-1-[(2-methylpropyl)amino]-1-oxobutan-2-yl]amino)-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication
0.000137
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
pH and temperature not specified in the publication