Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.23.45 extracted from

  • Ghosh, A.K.; Bilcer, G.; Harwood, C.; Kawahama, R.; Shin, D.; Hussain, K.A.; Hong, L.; Loy, J.A.; Nguyen, C.; Koelsch, G.; Ermolieff, J.; Tang, J.
    Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase) (2001), J. Med. Chem., 44, 2865-2868.
    View publication on PubMed
Search for more literature for 3.4.23.45

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Glu-Val-Asn-Leu-(S)-CH(OH)CH2-Ala-Ala-Glu-Phe
-
 Homo sapiens
Glu-Val-Asn-Leu-CONH-Ala-Ala-Glu-Phe inhibitors based on this structure, molecular size is substantially reduced while maintaining comparable enzyme inhibitory potencies Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
amyloid-beta precursor protein + H2O results in 40-42 residue amyloid-beta peptide Homo sapiens ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000016
-
 Glu-Val-Asn-Leu-(S)-CH(OH)CH2-Ala-Ala-Glu-Phe
-
 Homo sapiens
0.000036
-
 Glu-Val-Asn-Leu-CONH-Ala-Ala-Glu-Phe
-
 Homo sapiens