3.4.21.34: plasma kallikrein
This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.
Word Map on EC 3.4.21.34
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3.4.21.34
-
kininogens
-
coagulation
-
hypertension
-
plasmin
-
thrombin
-
urine
-
renin
-
aprotinin
-
arterial
-
prostate
-
plasminogen
-
angiotensin
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prostaglandin
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clot
-
fibrinolysis
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glandular
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chromogenic
-
thromboplastin
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prostate-specific
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angioedema
-
fibrinogen
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aldosterone
-
antithrombin
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elastase
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submandibular
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hageman
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kininase
-
urokinase
-
normotensive
-
high-molecular-weight
-
amidolytic
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prothrombin
-
renin-angiotensin
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hypotensive
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captopril
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trypsin-like
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hk2
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2-macroglobulin
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kaolin
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c1-inh
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natriuresis
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renin-angiotensin-aldosterone
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kunitz
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c1s
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c1-inhibitor
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hypertensives
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esterolytic
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medicine
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pharmacology
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2-antiplasmin
-
euglobulins
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antifibrinolytic
- 3.4.21.34
- kininogens
- coagulation
- hypertension
- plasmin
- thrombin
- urine
- renin
- aprotinin
- arterial
- prostate
- plasminogen
- angiotensin
- prostaglandin
- clot
-
fibrinolysis
- glandular
-
chromogenic
- thromboplastin
-
prostate-specific
- angioedema
- fibrinogen
- aldosterone
- antithrombin
- elastase
-
submandibular
-
hageman
-
kininase
- urokinase
-
normotensive
-
high-molecular-weight
-
amidolytic
- prothrombin
-
renin-angiotensin
-
hypotensive
- captopril
-
trypsin-like
- hk2
-
2-macroglobulin
- kaolin
-
c1-inh
-
natriuresis
-
renin-angiotensin-aldosterone
-
kunitz
- c1s
- c1-inhibitor
-
hypertensives
-
esterolytic
- medicine
- pharmacology
-
2-antiplasmin
-
euglobulins
-
antifibrinolytic
Reaction
selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =
Synonyms
alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein–kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein
ECTree
3.4.21.34 plasma kallikreinAdvanced search results
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Natural Substrates Products on EC 3.4.21.34 - plasma kallikrein
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
factor FXII + H2O
activated factor XII + ?
cleavage between Arg and Val
-
-
?
kininogen + H2O
heavy chain of kininogen + light chain of kininogen + bradykinin
-
high molecular weight substrate, serine protease
bradykinin is an inflammatory peptide
ir
low-molecular-weight kininogen + H2O
low-molecular-weight kinin + kallidin
-
-
kallidin is Lys-bradykinin or Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
?
modified kininogen + H2O
bradykinin + fragments of kininogen
-
high-molecular weight kininogen digested by human neutrophil elastase
-
ir
pro-urokinase type plasminogen activator + H2O
urokinase type plasminogen activator + ?
-
-
-
-
?
factor XI + H2O
activated factor XI + ?
-
proteolytic activation, part of the coagulation cascade
-
-
?
factor XII + H2O
?
activation of the factor XII, bound to negatively charged surfaces
-
ir
factor XII + H2O
?
activation of the factor XII, bound to negatively charged surfaces
-
ir
factor XII + H2O
?
activation of the factor XII, bound to negatively charged surfaces
-
ir
factor XII + H2O
activated factor XII + ?
-
proteolytic activation
-
-
?
high molecular weight kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
high molecular weight kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
high-molecular-weight kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
high-molecular-weight kininogen + H2O
bradykinin + fragments of kininogen
cleavage between Lys and Arg as wekk as Arg and Ser
-
-
?
high-molecular-weight kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
high-molecular-weight kininogen + H2O
high-molecular-weight kinin + bradykinin
-
-
bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
?
high-molecular-weight kininogen + H2O
high-molecular-weight kinin + bradykinin
-
pathways involving high-molecular-weight kininogen/high-molecular-weight kinin, overview
bradykinin is Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
-
?
kininogen + H2O
?
-
cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation
-
-
?
kininogen + H2O
?
-
cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation
-
-
?
kininogen + H2O
bradykinin + ?
-
the presence of S at P1' position for bradykinin release by human plasma kallikrein appears to be essential
-
-
?
kininogen + H2O
bradykinin + fragment of kininogen
-
enzyme is a cofactor in blood coagulation and modulates inflammation through release of bradykinin
-
ir
kininogen + H2O
bradykinin + fragment of kininogen
-
part of kallikrein-kininsystem
bradykinin is a potent mediator of inflammatory response
ir
kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
?
kininogen + H2O
bradykinin + fragments of kininogen
high-molecular weight kininogen
-
ir
kininogen + H2O
bradykinin + fragments of kininogen
-
high-molecular weight kininogen, involved in inflammatory reaction
-
ir
kininogen + H2O
bradykinin + fragments of kininogen
high-molecular weight kininogen
-
ir
kininogen + H2O
bradykinin + fragments of kininogen
-
-
-
-
?
kininogen + H2O
bradykinin + fragments of kininogen
high-molecular weight kininogen
-
ir
Prorenin + H2O
Renin + ?
activation of prorenin, involved in the renin-angiotensin system
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ir
Prorenin + H2O
Renin + ?
activation of prorenin, involved in the renin-angiotensin system
-
ir
Prorenin + H2O
Renin + ?
activation of prorenin, involved in the renin-angiotensin system
-
ir
additional information
?
-
-
overexpression of prolylcarboxypeptidase in CHO cells enhances plasma prekallikrein activation
-
-
?
additional information
?
-
defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect
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?
additional information
?
-
-
enzyme activity is enhanced in orthotopic liver transplant recipients
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?
additional information
?
-
-
involved in inflammatory processes via hydrolysis of complement
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?
additional information
?
-
-
involved in plasma and vascular fibrinolytic activity
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?
additional information
?
-
-
cathepsin may control the activity of plasma prekallikrein/kallikrein system proteins associated with either the cell surface or the extracellular matrix in (patho)physiological processes
-
-
?
additional information
?
-
-
the review indicates how the plasma kallikrein/kinin system and the plasma renin-angiotensin system are activated and interact in endotoxin or related forms of induced sepsis. Activation of both the plasma kallikrein/kinin system and the plasma renin-angiotensin system can lead to increased nitric oxide and prostaglandin formation
-
-
?
additional information
?
-
kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview
-
-
?
additional information
?
-
-
kallikrein participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation, it has different specific cellular functions dependent on the tissue, overview
-
-
?
additional information
?
-
-
plasma kallikrein activates neutrophil aggregation and degranulation, the enzyme is part of the kallikrein-kininogen-kinin system, KKS, kininogen plays a role in signaling pathways via the kininogen receptors, mechanism of inflammation related to KKS, overview
-
-
?
additional information
?
-
-
the enzyme involved in intrinsic blood clotting, the kallikrein-kinin system and fibrinolysis
-
-
?
additional information
?
-
-
the enzyme is part of the kallikrein-kininogen-kinin system, KKS, overview
-
-
?
additional information
?
-
-
the enzyme is part of the plasma kallikrein-kininogen-kinin system, PKKS, which is involved in cardiovascular disease and artherothrombosis, e.g. coronary heart disease and stroke in middle-aged men, overview
-
-
?
additional information
?
-
-
the enzyme is part of the plasma kallikrein/kinin system that consists of the protein factor XII, prekallikrein, and high-molecular-weight kininogen, intravascular assembly of the plasma kallikrein/kinin system, overview, it acts as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces, kallikrein is involved in development of arterial thrombosis, mechanisms, overview
-
-
?
additional information
?
-
-
active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation and stromal remodeling during mammary gland involution
-
-
?
additional information
?
-
may play a role in invasion of the host immune response
-
?
