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Literature summary for 3.4.21.34 extracted from
- Plasma prekallikrein its role in hereditary angioedema and health and disease (2018), Front. Med., 5, 3-3 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| factor XIIa | - |
Mus musculus | |
| factor XIIa | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| high-molecular-weight kininogen + H2O | Mus musculus | - |
bradykinin + fragments of kininogen | - |
? |  |
| high-molecular-weight kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| high-molecular-weight kininogen + H2O | - |
Mus musculus | bradykinin + fragments of kininogen | - |
? | |
| high-molecular-weight kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Mus musculus |
| PKA | - |
Homo sapiens |
| plasma PK | - |
Mus musculus |
| plasma PK | - |
Homo sapiens |
| prekallikrein | precursor | Mus musculus |
| prekallikrein | precursor | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | plasma prekallikrein-deficient mice have reduced thrombosis risk and plasma kallikrein inhibition is associated with reduced experimental gastroenterocolitis and arthritis in rodents | Mus musculus |
| physiological function | plasma prekallikrein has a critical role in acute attacks of hereditary angioedema. High prekallikrein is associated with accelerated vascular disease in diabetes and polymorphisms of prekallikrein that reduce high-molecular-weight kininogen binding are associated with protection from cardiovascular events | Mus musculus |
| physiological function | plasma prekallikrein has a critical role in acute attacks of hereditary angioedema. High prekallikrein is associated with accelerated vascular disease in diabetes and polymorphisms of prekallikrein that reduce high-molecular-weight kininogen binding are associated with protection from cardiovascular events | Homo sapiens |
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