3.4.21.34: plasma kallikrein
This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.
Word Map on EC 3.4.21.34
-
3.4.21.34
-
kininogens
-
coagulation
-
hypertension
-
plasmin
-
thrombin
-
urine
-
renin
-
aprotinin
-
arterial
-
prostate
-
plasminogen
-
angiotensin
-
prostaglandin
-
clot
-
fibrinolysis
-
glandular
-
chromogenic
-
thromboplastin
-
prostate-specific
-
angioedema
-
fibrinogen
-
aldosterone
-
antithrombin
-
elastase
-
submandibular
-
hageman
-
kininase
-
urokinase
-
normotensive
-
high-molecular-weight
-
amidolytic
-
prothrombin
-
renin-angiotensin
-
hypotensive
-
captopril
-
trypsin-like
-
hk2
-
2-macroglobulin
-
kaolin
-
c1-inh
-
natriuresis
-
renin-angiotensin-aldosterone
-
kunitz
-
c1s
-
c1-inhibitor
-
hypertensives
-
esterolytic
-
medicine
-
pharmacology
-
2-antiplasmin
-
euglobulins
-
antifibrinolytic
- 3.4.21.34
- kininogens
- coagulation
- hypertension
- plasmin
- thrombin
- urine
- renin
- aprotinin
- arterial
- prostate
- plasminogen
- angiotensin
- prostaglandin
- clot
-
fibrinolysis
- glandular
-
chromogenic
- thromboplastin
-
prostate-specific
- angioedema
- fibrinogen
- aldosterone
- antithrombin
- elastase
-
submandibular
-
hageman
-
kininase
- urokinase
-
normotensive
-
high-molecular-weight
-
amidolytic
- prothrombin
-
renin-angiotensin
-
hypotensive
- captopril
-
trypsin-like
- hk2
-
2-macroglobulin
- kaolin
-
c1-inh
-
natriuresis
-
renin-angiotensin-aldosterone
-
kunitz
- c1s
- c1-inhibitor
-
hypertensives
-
esterolytic
- medicine
- pharmacology
-
2-antiplasmin
-
euglobulins
-
antifibrinolytic
Reaction
selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =
Synonyms
alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein–kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein
ECTree
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Reference on EC 3.4.21.34 - plasma kallikrein
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Van der Graaf, F.; Tans, G.; Bouma, B.N.; Griffin, J.H.
Isolation and functional properties of the heavy and light chains of human plasma kallikrein
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Homo sapiens
Heber, H.; Geiger, R.; Heimburger, N.
Human plasma kallikrein: Purification, enzyme characterization and quantitative determination in plasma
Hoppe-Seyler's Z. Physiol. Chem.
359
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Homo sapiens
Colman, R.W.; Bagdasarian, A.
Human kallikrein and prekallikrein
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45
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Bos taurus, Homo sapiens
Sampaio, C.; Wong, S.C.; Shaw, E.
Human plasma kallikrein
Arch. Biochem. Biophys.
165
133-139
1974
Homo sapiens
Mashiko, H.; Kato, K.; Fujii, K.I.; Takahashi, H.
Studies on factor XII in porcine plasma: purification and its conversion to activated form by porcine plasma kallikrein
Biochim. Biophys. Acta
1296
198-206
1996
Sus scrofa
Evans, D.M.; Jones, D.M.; Pitt, G.R.; Suerias-Diaz, J.; Horton, J.; Ashworth, D.; Olsson, H.; Szelke, M.
Selective inhibitors of plasma kallikrein
Immunopharmacology
32
115-116
1996
Homo sapiens
Oliva, M.L.V.; Andrade, S.; Batista, I.F.C.; Sampaio, M.U.; Juliano, M.; Fritz, H.; Auerswald, E.A.; Sampaio, C.A.M.
Human plasma kallikrein and tissue kallikrein binding to a substrate based on the reactive site of a factor Xa inhibitor isolates from Bauhinia ungulata seeds
Immunopharmacology
45
145-149
1999
Homo sapiens, Sus scrofa
Diniz, M.R.V.; Oliveira, E.B.
Purification and properties of a kininogenin from the venom of Lachesis muta (bushmaster)
Toxicon
30
247-258
1992
Lachesis muta
Tada, M.; Wanaka, K.; Okamoto, S.; Okamoto, U.; Nakaya, Y.; Horie, N.; Hijkata-Okunomiya, A.; Tsuda, Y.; Okada, Y.
Purification method for human plasma kallikrein by a new affinity chromatography
Biol. Pharm. Bull.
21
105-108
1998
Homo sapiens
Seidah, N.G.; Sawyer, N.; Hamelin, J.; Mion, P.; Beaubien, G.; Brachpapa, L.; Rochemont, J.; Mbikay, M.; Chretien, M.
Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species
DNA Cell Biol.
9
737-748
1990
Mus musculus
Paquin, J.; Benjannet, S.; Sawyer, N.; Lazure, C.; Chretien, M.; Seidah, N.G.
Rat plasma kallikrein: purification, NH2-terminal sequencing and development of a specific radioimmunoassay
Biochim. Biophys. Acta
999
103-110
1989
Rattus norvegicus
Heimark, R.L.; Davie, E.W.
Bovine and human plasma prekallikrein
Methods Enzymol.
80
157-173
1981
Bos taurus, Homo sapiens
Naess, F.; Roeise, O.; Johansen, H.T.; Stadaas, J.O.; Aasen, A.O.
Hemodynamic and proteolytic effects of intravenous injection of purified human plasma kallikrein
Am. J. Physiol.
263
405-409
1992
Homo sapiens
-
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P03952), Rattus norvegicus (P14272), Mus musculus (P26262)
Cavalcanti, M.d.S.M.; Oliva, M.L.V.; Fritz, H.; Jochum, M.; Mentele, R.; Sampaio, M.; Coelho, L.C.B.B.; Batista, I.F.C.; Sampaio, C.A.M.
Characterization of a Kunitz trypsin inhibitor with one disulfide bridge purified from Swartzia pickellii
Biochem. Biophys. Res. Commun.
291
635-639
2002
Homo sapiens
Parthasarathy, N.; Torti, S.V.; Torti, F.M.
Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release
Biochem. J.
365
279-286
2002
Homo sapiens
Almeida, P.C.; Chagas, J.R.; Cezari, M.H.; Juliano, M.A.; Juliano, L.
Hydrolysis by plasma kallikrein of fluorogenic peptides derived from prorenin processing site
Biochim. Biophys. Acta
1479
83-90
2000
Homo sapiens, Rattus norvegicus
Oliva, M.L.; Santomauro-Vaz, E.M.; Andrade, S.A.; Juliano, M.A.; Pott, V.J.; Sampaio, M.U.; Sampaio, C.A.
Synthetic peptides and fluorogenic substrates related to the reactive site sequence of Kunitz-type inhibitors isolated from Bauhinia: interaction with human plasma kallikrein
Biol. Chem.
382
109-113
2001
Homo sapiens
Dulinski, R.; Suder, P.; Guevara-Lora, I.; Rapala-Kozik, M.; Potempa, J.; Silberring, J.; Imamura, T.; Travis, J.; Kozik, A.
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins
Biol. Chem.
384
929-937
2003
Homo sapiens
Tada, M.; Tsuda, Y.; Wanaka, K.; Hijikata-Okunomiya, A.; Horie, N.; Okamoto, U.; Okamoto, S.; Okada, Y.
Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization
Biol. Pharm. Bull.
24
520-524
2001
Homo sapiens
Fukumizu, A.; Tsuda, Y.; Wanaka, K.; Tada, M.; Okamoto, S.; Hijikata-Okunomiya, A.; Okada, Y.
Amino acids and peptides. LIII. Synthesis and biological activities of some pseudo-peptide analogs of PKSI-527, a plasma kallikrein selective inhibitor: the importance of the peptide backbone
Chem. Pharm. Bull.
47
1141-1144
1999
Homo sapiens
Okada, Y.; Tsuda, Y.; Tada, M.; Wanaka, K.; Okamoto, U.; Hijikata-Okunomiya, A.; Okamoto, S.
Development of potent and selective plasmin and plasma kallikrein inhibitors and studies on the structure-activity relationship
Chem. Pharm. Bull.
48
1964-1972
2000
Homo sapiens
Oliva, M.L.; Mendes, C.R.; Santomauro-Vaz, E.M.; Juliano, M.A.; Mentele, R.; Auerswald, E.A.; Sampaio, M.U.; Sampaio, C.A.
Bauhinia bauhinioides plasma kallikrein inhibitor: interaction with synthetic peptides and fluorogenic peptide substrates related to the reactive site sequence
Curr. Med. Chem.
8
977-984
2001
Homo sapiens
Rojkjaer, R.; Schmaier, A.H.
Activation of the plasma kallikrein/kinin system on endothelial cell membranes
Immunopharmacology
43
109-114
1999
Homo sapiens
Hayashi, J.; Salomon, D.R.; Hugli, T.E.
Elevated kallikrein activity in plasma from stable liver transplant recipients
Int. Immunopharmacol.
2
1667-1680
2002
Homo sapiens
Gozzo, A.J.; Nunes, V.A.; Carmona, A.K.; Nader, H.B.; von Dietrich, C.P.; Silveira, V.L.; Shimamoto, K.; Ura, N.; Sampaio, M.U.; Sampaio, C.A.; Araujo, M.S.
Glycosaminoglycans affect the action of human plasma kallikrein on kininogen hydrolysis and inflammation
Int. Immunopharmacol.
2
1861-1865
2002
Homo sapiens
Peek, M.; Moran, P.; Mendoza, N.; Wickramasinghe, D.; Kirchhofer, D.
Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa
J. Biol. Chem.
277
47804-47809
2002
Homo sapiens
Kirchhofer, D.; Peek, M.; Li, W.; Stamos, J.; Eigenbrot, C.; Kadkhodayan, S.; Elliott, J.M.; Corpuz, R.T.; Lazarus, R.A.; Moran, P.
Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1
J. Biol. Chem.
278
36341-36349
2003
Homo sapiens
Cerf, M.E.; Raidoo, D.M.
Immunolocalization of plasma kallikrein in human brain
Metab. Brain Dis.
15
315-323
2000
Homo sapiens
Cocude, C.; Pierrot, C.; Cetre, C.; Fontaine, J.; Godin, C.; Capron, A.; Khalife, J.
Identification of a developmentally regulated Schistosoma mansoni serine protease homologous to mouse plasma kallikrein and human factor I
Parasitology
118
389-396
1999
Schistosoma mansoni (Q9TYH4)
-
Sulikowski, T.; Bauer, B.A.; Patston, P.A.
alpha1-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1
Protein Sci.
11
2230-2236
2002
Homo sapiens
Briseid, K.; Johannesen, S.
Part of purified human plasma kallikrein removed together with a remaining IgG fraction - immunoblot experiments and functional tests
Scand. J. Clin. Lab. Invest.
62
21-24
2002
Homo sapiens
Shariat-Madar, Z.; Rahimy, E.; Mahdi, F.; Schmaier, A.H.
Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells
Am. J. Physiol. Heart Circ. Physiol.
289
H2697-H2703
2005
Cricetulus griseus
Barros, N.M.; Puzer, L.; Tersariol, I.L.; Oliva, M.L.; Sampaio, C.A.; Carmona, A.K.; da Motta, G.
Plasma prekallikrein/kallikrein processing by lysosomal cysteine proteases
Biol. Chem.
385
1087-1091
2004
Homo sapiens
Neth, P.; Arnhold, M.; Sidarovich, V.; Bhoola, K.D.; Fink, E.
Expression of the plasma prekallikrein gene: utilization of multiple transcription start sites and alternative promoter regions
Biol. Chem.
386
101-109
2005
Homo sapiens, Rattus norvegicus
Vonnahme, K.A.; Fernando, S.C.; Ross, J.W.; Ashworth, M.D.; DeSilva, U.; Malayer, J.R.; Geisert, R.D.
Porcine endometrial expression of kininogen, factor XII, and plasma kallikrein in cyclic and pregnant gilts
Biol. Reprod.
70
132-138
2004
Sus scrofa
Young, W.B.; Rai, R.; Shrader, W.D.; Burgess-Henry, J.; Hu, H.; Elrod, K.C.; Sprengeler, P.A.; Katz, B.A.; Sukbuntherng, J.; Mordenti, J.
Small molecule inhibitors of plasma kallikrein
Bioorg. Med. Chem. Lett.
16
2034-2036
2006
Rattus norvegicus
Rosatelli, T.B.; Roselino, A.M.; Dellalibera-Joviliano, R.; Reis, M.L.; Donadi, E.A.
Increased activity of plasma and tissue kallikreins, plasma kininase II and salivary kallikrein in pemphigus foliaceus (fogo selvagem)
Br. J. Dermatol.
152
650-657
2005
Homo sapiens
Tang, J.; Yu, C.L.; Williams, S.R.; Springman, E.; Jeffery, D.; Sprengeler, P.A.; Estevez, A.; Sampang, J.; Shrader, W.; Spencer, J.; Young, W.; McGrath, M.; Katz, B.A.
Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein
J. Biol. Chem.
280
41077-41089
2005
Homo sapiens (Q92876), Homo sapiens
Shariat-Madar, Z.; Schmaier, A.H.
The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis
J. Endotoxin Res.
10
3-13
2004
Homo sapiens
Storini, C.; Bergamaschini, L.; Gesuete, R.; Rossi, E.; Maiocchi, D.; De Simoni, M.G.
Selective inhibition of plasma kallikrein protects brain from reperfusion injury
J. Pharmacol. Exp. Ther.
318
849-854
2006
Mus musculus
Ravindran, S.; Grys, T.E.; Welch, R.A.; Schapira, M.; Patston, P.A.
Inhibition of plasma kallikrein by C1-inhibitor: role of endothelial cells and the amino-terminal domain of C1-inhibitor
Thromb. Haemost.
92
1277-1283
2004
Homo sapiens
Gozzo, A.J.; Nunes, V.A.; Cruz-Silva, I.; Carmona, A.K.; Nader, H.B.; Faljoni-Alario, A.; Sampaio, M.U.; Araujo, M.S.
Heparin modulation of human plasma kallikrein on different substrates and inhibitors
Biol. Chem.
387
1129-1138
2006
Homo sapiens
Fink, E.; Bhoola, K.D.; Snyman, C.; Neth, P.; Figueroa, C.D.
Cellular expression of plasma prekallikrein in human tissues
Biol. Chem.
388
957-963
2007
Homo sapiens (P03952), Homo sapiens
Isawa, H.; Orito, Y.; Jingushi, N.; Iwanaga, S.; Morita, A.; Chinzei, Y.; Yuda, M.
Identification and characterization of plasma kallikrein-kinin system inhibitors from salivary glands of the blood-sucking insect Triatoma infestans
FEBS J.
274
4271-4286
2007
Homo sapiens
Schmaier, A.H.
Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system
Int. Immunopharmacol.
8
161-165
2008
Homo sapiens
Govers-Riemslag, J.W.; Smid, M.; Cooper, J.A.; Bauer, K.A.; Rosenberg, R.D.; Hack, C.E.; Hamulyak, K.; Spronk, H.M.; Miller, G.J.; ten Cate, H.
The plasma kallikrein-kinin system and risk of cardiovascular disease in men
J. Thromb. Haemost.
5
1896-1903
2007
Homo sapiens
Sainz, I.M.; Pixley, R.A.; Colman, R.W.
Fifty years of research on the plasma kallikrein-kinin system: from protein structure and function to cell biology and in-vivo pathophysiology
Thromb. Haemost.
98
77-83
2007
Homo sapiens
Saito, A.
Plasma kallikrein is activated on dermatan sulfate and cleaves factor H
Biochem. Biophys. Res. Commun.
370
646-650
2008
Homo sapiens
Lima, A.R.; Alves, F.M.; Angelo, P.F.; Andrade, D.; Blaber, S.I.; Blaber, M.; Juliano, L.; Juliano, M.A.
S(1) and S(2) subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen
Biol. Chem.
389
1487-1494
2008
Homo sapiens
Planque, C.; Li, L.; Zheng, Y.; Soosaipillai, A.; Reckamp, K.; Chia, D.; Diamandis, E.P.; Goodglick, L.
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
Clin. Cancer Res.
14
1355-1362
2008
Homo sapiens
Lehmann, A.
Ecallantide (DX-88), a plasma kallikrein inhibitor for the treatment of hereditary angioedema and the prevention of blood loss in on-pump cardiothoracic surgery
Expert. Opin. Biol. Ther.
8
1187-1199
2008
Homo sapiens
Phipps, J.A.; Clermont, A.C.; Sinha, S.; Chilcote, T.J.; Bursell, S.E.; Feener, E.P.
Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability
Hypertension
53
175-181
2009
Rattus norvegicus
Lilla, J.N.; Joshi, R.V.; Craik, C.S.; Werb, Z.
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation and stromal remodeling during mammary gland involution
J. Biol. Chem.
284
13792-13803
2009
Mus musculus
Sexton, D.J.; Chen, T.; Martik, D.; Kuzmic, P.; Kuang, G.; Chen, J.; Nixon, A.E.; Zuraw, B.L.; Forteza, R.M.; Abraham, W.M.; Wood, C.R.
Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases
Biochem. J.
422
383-392
2009
Homo sapiens
Stoop, A.A.; Joshi, R.V.; Eggers, C.T.; Craik, C.S.
Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation
Biol. Chem.
391
425-433
2010
Homo sapiens
Abid, K.; Rochat, B.; Lassahn, P.G.; Stoecklin, R.; Michalet, S.; Brakch, N.; Aubert, J.F.; Vatansever, B.; Tella, P.; De Meester, I.; Grouzmann, E.
Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein
J. Biol. Chem.
284
24715-24724
2009
Homo sapiens
Pönitz, V.; Govers-Riemslag, J.; Brügger-Andersen, T.; Ten Cate, H.; Nilsen, D.
Inhibitor complexes of the plasma kallikrein-kinin system and outcome prediction in patients following admission for chest pain
J. Thromb. Haemost.
7
1231-1233
2009
Homo sapiens
Almeida, S.S.; Barros, C.C.; Moraes, M.R.; Russo, F.J.; Haro, A.S.; Rosa, T.S.; Alves, M.F.; Pesquero, J.B.; Carmona, A.K.; Bacurau, R.F.; Araujo, R.C.
Plasma Kallikrein and Angiotensin I-converting enzyme N- and C-terminal domain activities are modulated by the insertion/deletion polymorphism
Neuropeptides
44
139-143
2010
Homo sapiens
Earl, S.T.; Richards, R.; Johnson, L.A.; Flight, S.; Anderson, S.; Liao, A.; de Jersey, J.; Masci, P.P.; Lavin, M.F.
Identification and characterisation of Kunitz-type plasma kallikrein inhibitors unique to Oxyuranus sp. snake venoms
Biochimie
94
365-373
2011
Homo sapiens
Vergiliana, J.F.; Asokananthan, N.; Stewart, G.A.
Activation of the plasma kallikrein-kinin system on human lung epithelial cells
Biol. Chem.
391
1067-1077
2010
Homo sapiens
Varano Della Vergiliana, J.F.; Lansley, S.; Tan, A.L.; Creaney, J.; Lee, Y.C.; Stewart, G.A.
Mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation
Biol. Chem.
392
633-642
2011
Homo sapiens
Yasuda, Y.; Lu, Z.; Kato, N.; Jomori, T.
Change in blood kinin and plasma porcine pancreatic kallikrein concentrations after oral administration of kallikrein formulation in dog
Biol. Pharm. Bull.
34
1518-1521
2011
Sus scrofa
Abdallah, R.T.; Keum, J.S.; El-Shewy, H.M.; Lee, M.H.; Wang, B.; Gooz, M.; Luttrell, D.K.; Luttrell, L.M.; Jaffa, A.A.
Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors
J. Biol. Chem.
285
35206-35215
2010
Homo sapiens
Liu, J.; Gao, B.B.; Clermont, A.C.; Blair, P.; Chilcote, T.J.; Sinha, S.; Flaumenhaft, R.; Feener, E.P.
Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein
Nat. Med.
17
206-210
2011
Rattus norvegicus
Renne, T.
The vascular side of plasma kallikrein
Blood
125
589-590
2015
Mus musculus
Baeriswyl, V.; Rapley, H.; Pollaro, L.; Stace, C.; Teufel, D.; Walker, E.; Chen, S.; Winter, G.; Tite, J.; Heinis, C.
Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases
ChemMedChem
7
1173-1176
2012
Homo sapiens (P03952), Homo sapiens
Ravindran, S.; Schapira, M.; Patston, P.A.
Modulation of C1-inhibitor and plasma kallikrein activities by type IV collagen
Int. J. Biomater.
2012
212417
2012
Homo sapiens
Kenniston, J.; Faucette, R.; Martik, D.; Comeau, S.; Lindberg, A.; Kopacz, K.; Conley, G.; Chen, J.; Viswanathan, M.; Kastrapeli, N.; Cosic, J.; Mason, S.; DiLeo, M.; Abendroth, J.; Kuzmic, P.; Ladner, R.; Edwards, T.; TenHoor, C.; Adelman, B.; Nixon, A.;
Inhibition of plasma kallikrein by a highly specific active site blocking antibody
J. Biol. Chem.
289
23596-23608
2014
Macaca fascicularis, Mus musculus, Rattus norvegicus, Homo sapiens (P03952), Homo sapiens
Koumandou, V.L.; Scorilas, A.
Evolution of the plasma and tissue kallikreins, and their alternative splicing isoforms
PLoS ONE
8
e68074
2013
Homo sapiens
Veronez, C.L.; Nascimento, F.D.; Melo, K.R.; Nader, H.B.; Tersariol, I.L.; Motta, G.
The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface
PLoS ONE
9
e91280
2014
Homo sapiens
Renne, T.; Gruber, A.
Plasma kallikrein: Novel functions for an old protease
Thromb. Haemost.
107
1012-1013
2012
Mus musculus
Bjoerkqvist, J.; Jaemsae, A.; Renne, T.
Plasma kallikrein: the bradykinin-producing enzyme
Thromb. Haemost.
110
399-407
2013
Homo sapiens
Pathak, M.; Wong, S.S.; Dreveny, I.; Emsley, J.
Structure of plasma and tissue kallikreins
Thromb. Haemost.
110
423-433
2013
Homo sapiens (P03952)
Feener, E.P.; Zhou, Q.; Fickweiler, W.
Role of plasma kallikrein in diabetes and metabolism
Thromb. Haemost.
110
434-441
2013
Mus musculus
Ottaiano, T.F.; Andrade, S.S.; de Oliveira, C.; Silva, M.C.C.; Buri, M.V.; Juliano, M.A.; Girao, M.J.B.C.; Sampaio, M.U.; Schmaier, A.H.; Wlodawer, A.; Maffei, F.H.A.; Oliva, M.L.V.
Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP
Biochimie
135
72-81
2017
Homo sapiens
Lieb, W.; Chen, M.; Teumer, A.; De Boer, R.; Lin, H.; Fox, E.; Musani, S.; Wilson, J.; Wang, T.; Voelzke, H.; Petersen, A.; Meisinger, C.; Nauck, M.; Schlesinger, S.; Li, Y.; Menard, J.; Hercberg, S.; Wichmann, H.; Voelker, U.; Rawal, R.; Bidlingmaier, M.
Genome-wide meta-analyses of plasma renin activity and concentration reveal association with the kininogen 1 and prekallikrein genes
Circ. Cardiovasc. Genet.
8
131-140
2015
Homo sapiens
Fischer, C.; Lamer, T.; Wang, W.; McKinnie, S.M.K.; Iturrioz, X.; Llorens-Cortes, C.; Oudit, G.Y.; Vederas, J.C.
Plasma kallikrein cleaves and inactivates apelin-17 Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents
Eur. J. Med. Chem.
166
119-124
2019
Homo sapiens
Xu, M.; Chen, Y.; Xu, P.; Andreasen, P.A.; Jiang, L.; Li, J.; Huang, M.
Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217
FEBS Lett.
592
2658-2667
2018
Mus musculus (P26262), Mus musculus
Schmaier, A.H.
Plasma prekallikrein its role in hereditary angioedema and health and disease
Front. Med.
5
3-3
2018
Homo sapiens, Mus musculus
Motta, G.; Tersariol, I.L.S.
Modulation of the plasma kallikrein-kinin system proteins performed by heparan sulfate proteoglycans
Front. Physiol.
8
481
2017
Homo sapiens
Teufel, D.P.; Bennett, G.; Harrison, H.; van Rietschoten, K.; Pavan, S.; Stace, C.; Le Floch, F.; Van Bergen, T.; Vermassen, E.; Barbeaux, P.; Hu, T.T.; Feyen, J.H.M.; Vanhove, M.
Stable and long-lasting, novel bicyclic peptide plasma kallikrein inhibitors for the treatment of diabetic macular edema
J. Med. Chem.
61
2823-2836
2018
Rattus norvegicus
Partridge, J.R.; Choy, R.M.; Silva-Garcia, A.; Yu, C.; Li, Z.; Sham, H.; Metcalf, B.
Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition
J. Struct. Biol.
206
170-182
2019
Homo sapiens (P03952)
Li, C.; Voos, K.M.; Pathak, M.; Hall, G.; McCrae, K.R.; Dreveny, I.; Li, R.; Emsley, J.
Plasma kallikrein structure reveals apple domain disc rotated conformation compared to factor XI
J. Thromb. Haemost.
17
759-770
2019
Homo sapiens (P03952), Homo sapiens
Goebel, K.; Asaridou, C.M.; Merker, M.; Eichler, S.; Herrmann, A.M.; Geuss, E.; Ruck, T.; Schuengel, L.; Groeneweg, L.; Narayanan, V.; Schneider-Hohendorf, T.; Gross, C.C.; Wiendl, H.; Kehrel, B.E.; Kleinschnitz, C.; Meuth, S.G.
Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release
Proc. Natl. Acad. Sci. USA
116
271-276
2019
Homo sapiens, Mus musculus
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