3.4.21.34: plasma kallikrein

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For detailed information about plasma kallikrein, go to the full flat file.

Reaction

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =

Synonyms

alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein�kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.34 plasma kallikrein

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Results	in table
33	Activating Compound
29	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
5	Crystallization (Commentary)
6714	Disease/ Diagnostics
3	Expression
23	General Information
2	General Stability
2	IC50 Value
129	Inhibitors
1	kcat/KM [mM/s]
39	Ki Value [mM]
33	KM Value [mM]
36	Localization
27	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
98	Organism
18	PDB ID
14	pH Optimum
1	pI Value
9	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
116	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
223	Substrates and Products (Substrate)
16	Subunits
83	Synonyms
19	Temperature Optimum [°C]
24	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.34 - plasma kallikrein

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

enzyme bound to inhibitor, hanging drop vapor diffusion method, using 0.2 M potassium dihydrogen phosphate, 23% (w/v) PEG3350

Homo sapiens

P03952

754503

in complex with human IgG1 monoclonal antibody DX-2930, hanging drop vapor diffusion method, using 0.1 M Bis-Tris, pH 6.5, 20% (w/v) PEG 5000 MME

Homo sapiens

P03952

732147

protease domain recombinantly expressed in Pichia pastoris or in the baculovirus/Sf9 system. Structure for the endoglycosidase H-deglycosylated protease domain produced from Pichia pastoris is determined at 1.4 A. Structure for the mutagenically deglycosylated form produced from Sf9 cells is determined at 1.4 A

Homo sapiens

Q92876

669411

sitting drop vapor diffusion method, using 0.1 M carboxylic acids, 0.1 M HEPES/MOPS pH 7.5, 12.5% (v/v) 2-methyl-2,4-pentanediol, 12.5% (w/v) PEG1000, 12.5% (w/v) PEG3350 and a drop containing 0.1 M carboxylic acids, 0.1 M Tris/Bicine pH 8.5, 20% (w/v) PEG 500 MME

Homo sapiens

P03952

754520

apoenzyme and in complex with mupain-1-16, sitting drop vapor diffusion method, using 25% (w/v) poly(ethylene glycol) 3350, 0.1 M Tris-HCl pH8.5, 0.1 M NaCl

Mus musculus

P26262

753574