3.4.21.34: plasma kallikrein

This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.

Reaction

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =

Synonyms

alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein�kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.34 plasma kallikrein

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Results	in table
33	Activating Compound
29	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
5	Crystallization (Commentary)
6714	Disease/ Diagnostics
3	Expression
23	General Information
2	General Stability
2	IC50 Value
129	Inhibitors
1	kcat/KM [mM/s]
39	Ki Value [mM]
33	KM Value [mM]
36	Localization
27	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
98	Organism
18	PDB ID
14	pH Optimum
1	pI Value
9	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
116	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
223	Substrates and Products (Substrate)
16	Subunits
83	Synonyms
19	Temperature Optimum [°C]
24	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.21.34 - plasma kallikrein

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Drosophila S2 cells

Homo sapiens

P03952

754520

expressed in Pichia pastoris strain, X-33

Mus musculus

P26262

753574

expression of the protease domain in Pichia pastoris as a heterologously glycosylated zymogen that is activated by limited trypsin digestion and treated with endoglycosidase H deglycosidase to reduce heterogeneity from the glycosylation. In the baculovirus/Sf9 system, homogenous, crystallizable, and nonglycosylated protein is expressed after mutagenizing three asparagines to glutamate. The activity of the catalytic domain is similar to that of the full-length protein

Homo sapiens

Q92876

669411

screening of genomic library, DNA and amino acid sequence determination and analysis

Schistosoma mansoni

Q9TYH4

653408