Activating Compound | Comment | Organism | Structure |
---|---|---|---|
coagulation factor XIIa | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha 2 macroglobulin | - |
Mus musculus | |
C1-inhibitor | - |
Mus musculus | |
Protein C inhibitor | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | Mus musculus | - |
factor XIIa + ? | - |
? | |
high molecular weight kininogen + H2O | Mus musculus | - |
bradykinin + fragments of kininogen | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
vascular endothelium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
factor X + H2O | - |
Mus musculus | factor XIIa + ? | - |
? | |
high molecular weight kininogen + H2O | - |
Mus musculus | bradykinin + fragments of kininogen | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KLKb1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | C1-inhibitor deficiency can lead to uncontrolled enzyme activity, which is a clinically significant cause of hereditary angioedema | Mus musculus |
physiological function | diabetes is associated with increased intrinsic pathway activity, which is mediated in part by plasma kallikrein (PK). PK-mediated activation of the plasminogen cascade is implicated in adipocyte differentiation and adipogenesis during mammary gland involution via activation of plasmin-mediated cleavage of preadipocyte stromal matrix | Mus musculus |