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Literature summary for 3.4.21.34 extracted from

  • Renne, T.
    The vascular side of plasma kallikrein (2015), Blood, 125, 589-590.
    View publication on PubMed
Search for more literature for 3.4.21.34

Activating Compound

Activating Compound Comment Organism Structure
activated factor XII
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
factor XII + H2O Mus musculus
-
 activated factor XII + ?
-
 ?
kininogen + H2O Mus musculus
-
 bradykinin + fragments of kininogen
-
 ?
Prorenin + H2O Mus musculus
-
 Renin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
factor XII + H2O
-
 Mus musculus activated factor XII + ?
-
 ?
kininogen + H2O
-
 Mus musculus bradykinin + fragments of kininogen
-
 ?
Prorenin + H2O
-
 Mus musculus Renin + ?
-
 ?

General Information

General Information Comment Organism
malfunction prekallikrein-deficient mice are protected from increased BK-driven vascular leakage in retinal vessels, ferric chloride-triggered arterial thrombosis, and hypotension in anaphylaxis models. Prekallikrein-deficient mice have defective ex vivo plasma clotting that leads to a prolonged activated partial thromboplastin time. Chronic plasma kallikrein deficiency induces vascular alterations that cannot be reverted by short-term normalizing plasma kallikrein levels and provides a thromboprotective activity in addition to reduced contact activation Mus musculus
physiological function plasma kallikrein regulates tissue factor expression that is mediated by the kallikrein-kinin and renin-angiotensin systems independently of factor XII contact activation Mus musculus