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Literature summary for 3.4.21.34 extracted from
- Inhibition of plasma kallikrein by a highly specific active site blocking antibody (2014), J. Biol. Chem., 289, 23596-23608.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| factor XIIa | - |
Mus musculus | |
| factor XIIa | - |
Rattus norvegicus | |
| factor XIIa | - |
Macaca fascicularis | |
| factor XIIa | - |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with human IgG1 monoclonal antibody DX-2930, hanging drop vapor diffusion method, using 0.1 M Bis-Tris, pH 6.5, 20% (w/v) PEG 5000 MME | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| C1-inhibitor | - |
Homo sapiens | |
| C1-inhibitor | - |
Macaca fascicularis | |
| C1-inhibitor | - |
Mus musculus | |
| C1-inhibitor | - |
Rattus norvegicus | |
| human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Homo sapiens | |
| human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Macaca fascicularis | |
| human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Mus musculus | |
| human IgG1 monoclonal antibody DX-2930 | potently and specifically inhibits plasma kallikrein | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | Mus musculus | - |
bradykinin + fragments of kininogen | - |
? |  |
| kininogen + H2O | Rattus norvegicus | - |
bradykinin + fragments of kininogen | - |
? | |
| kininogen + H2O | Macaca fascicularis | - |
bradykinin + fragments of kininogen | - |
? | |
| kininogen + H2O | Homo sapiens | - |
bradykinin + fragments of kininogen | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P03952 | - |
- |
| Macaca fascicularis | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Mus musculus | - |
| blood plasma | - |
Rattus norvegicus | - |
| blood plasma | - |
Macaca fascicularis | - |
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| kininogen + H2O | - |
Mus musculus | bradykinin + fragments of kininogen | - |
? | |
| kininogen + H2O | - |
Rattus norvegicus | bradykinin + fragments of kininogen | - |
? | |
| kininogen + H2O | - |
Macaca fascicularis | bradykinin + fragments of kininogen | - |
? | |
| kininogen + H2O | - |
Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKal | - |
Mus musculus |
| PKal | - |
Rattus norvegicus |
| PKal | - |
Macaca fascicularis |
| PKal | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00000007 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Macaca fascicularis | |
| 0.00000012 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Homo sapiens | |
| 0.00000017 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Mus musculus | |
| 0.00000017 | - |
human IgG1 monoclonal antibody DX-2930 | at pH 7.5 and 30°C | Rattus norvegicus |
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