Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Elastase | of human neutrophils, degrades kininogen itself to kinin-containing fragments and therefore quenches the kininogen degeneration/bradykinin generation by plasma kallikrein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | plasma | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
kininogen + H2O | Homo sapiens | high-molecular weight kininogen, involved in inflammatory reaction | bradykinin + fragments of kininogen | - |
ir | |
modified kininogen + H2O | Homo sapiens | high-molecular weight kininogen digested by human neutrophil elastase | bradykinin + fragments of kininogen | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ISLMKRPPGFSPFRSSR + H2O | RPPGFSPFR is bradykinin, synthetic peptide containing the internal kinin sequence, 2 cleavage sites, the C-terminal one being preferred | Homo sapiens | ISLMKR + RPPGFSPFR + SSR | - |
? | |
kininogen + H2O | high-molecular weight kininogen, preferred substrate | Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | low-molecular weight kininogen, low activity | Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
kininogen + H2O | high-molecular weight kininogen, involved in inflammatory reaction | Homo sapiens | bradykinin + fragments of kininogen | - |
ir | |
modified kininogen + H2O | high-molecular weight kininogen digested by human neutrophil elastase | Homo sapiens | bradykinin + fragments of kininogen | - |
? | |
modified kininogen + H2O | high-molecular weight kininogen digested by human neutrophil elastase | Homo sapiens | bradykinin + fragments of kininogen | - |
ir | |
modified kininogen + H2O | low-molecular weight kininogen digested by human neutrophil elastase, 26 amino acids cleaved off, is a better substrate than native low-molecular weight kininogen | Homo sapiens | bradykinin + fragments of kininogen | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |