3.4.21.34: plasma kallikrein

This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.

Reaction

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =

Synonyms

alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein�kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.34 plasma kallikrein

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Results	in table
33	Activating Compound
29	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
5	Crystallization (Commentary)
6714	Disease/ Diagnostics
3	Expression
23	General Information
2	General Stability
2	IC50 Value
129	Inhibitors
1	kcat/KM [mM/s]
39	Ki Value [mM]
33	KM Value [mM]
36	Localization
27	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
98	Organism
18	PDB ID
14	pH Optimum
1	pI Value
9	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
116	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
223	Substrates and Products (Substrate)
16	Subunits
83	Synonyms
19	Temperature Optimum [°C]
24	Turnover Number [1/s]

Application

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Application on EC 3.4.21.34 - plasma kallikrein

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

4 entries

pharmacology

Homo sapiens

-

design of specific inhibitors for proteases like plasma kallikrein, but not protein C, to diminish the complement hydrolysis and coagulation during sepsis

653796

medicine

Mus musculus

-

DX-88 has a strong neuroprotective effect in the early phases of brain ischemia preventing reperfusion injury and indicates that inhibition of plasma kallikrein may be useful tool in the strategy aimed at reducing the detrimental effects linked to reperfusion

670001

medicine

Sus scrofa

-

porcine pancreatic kallikrein is absorbed after oral administration and to exert its pharmacological action via kinins produced by kininogen degradation in dogs

717318

medicine

Mus musculus

-

targeting plasma kallikrein may offer a strategy for prevention or treatment of thrombosis

732928

medicine

Homo sapiens

-

enzyme inhibition can decrease blood-brain barrier damage and cell invasion during neuroinflammation and may offer a strategy for the treatment of multiple sclerosis

755272