3.4.21.34: plasma kallikrein

This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.

Word Map on EC 3.4.21.34

3.4.21.34

kininogens

coagulation

hypertension

plasmin

thrombin

urine

renin

aprotinin

arterial

prostate

plasminogen

angiotensin

prostaglandin

clot

fibrinolysis

glandular

chromogenic

thromboplastin

prostate-specific

angioedema

fibrinogen

aldosterone

antithrombin

elastase

submandibular

hageman

kininase

urokinase

normotensive

high-molecular-weight

amidolytic

prothrombin

renin-angiotensin

hypotensive

captopril

trypsin-like

hk2

2-macroglobulin

kaolin

c1-inh

natriuresis

renin-angiotensin-aldosterone

kunitz

c1s

c1-inhibitor

hypertensives

esterolytic

medicine

pharmacology

2-antiplasmin

euglobulins

antifibrinolytic

Reaction

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =

Synonyms

alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein�kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.34 plasma kallikrein

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
33	Activating Compound
29	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
5	Crystallization (Commentary)
6714	Disease/ Diagnostics
3	Expression
23	General Information
2	General Stability
2	IC50 Value
129	Inhibitors
1	kcat/KM [mM/s]
39	Ki Value [mM]
33	KM Value [mM]
36	Localization
27	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
98	Organism
18	PDB ID
14	pH Optimum
1	pI Value
9	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
116	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
223	Substrates and Products (Substrate)
16	Subunits
83	Synonyms
19	Temperature Optimum [°C]
24	Turnover Number [1/s]

Activating Compound

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Activating Compound on EC 3.4.21.34 - plasma kallikrein

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Activating Compound Search

activated factor XII

Mus musculus

731539

coagulation factor XIIa

2 entries

dermatan sulfate

Homo sapiens

dermatan sulfate induces contact activation and activates plasma kallikrein-mediated cleavage of factor H

695990

Factor XII

Homo sapiens

essential for activation on artificial surfaces

651467

factor XIIa

9 entries

kininogen

Homo sapiens

dependent on in vivo, high molecular weight, in complex with prekallikrein

651467

Lima bean trypsin inhibitor

Homo sapiens

651518

prolylcarboxypeptidase

thrombin

Zn2+

prekallikrein, required, optimal activation on cells at 0.008 mM, activation range 0.005-0.01 mM, higher concentration inhibit, regulatory role

651467

additional information

8 entries