3.4.21.34: plasma kallikrein

This is an abbreviated version!
For detailed information about plasma kallikrein, go to the full flat file.

Word Map on EC 3.4.21.34

3.4.21.34

kininogens

coagulation

hypertension

plasmin

thrombin

urine

renin

aprotinin

arterial

prostate

plasminogen

angiotensin

prostaglandin

clot

fibrinolysis

glandular

chromogenic

thromboplastin

prostate-specific

angioedema

fibrinogen

aldosterone

antithrombin

elastase

submandibular

hageman

kininase

urokinase

normotensive

high-molecular-weight

amidolytic

prothrombin

renin-angiotensin

hypotensive

captopril

trypsin-like

hk2

2-macroglobulin

kaolin

c1-inh

natriuresis

renin-angiotensin-aldosterone

kunitz

c1s

c1-inhibitor

hypertensives

esterolytic

medicine

pharmacology

2-antiplasmin

euglobulins

antifibrinolytic

Reaction

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin =

Synonyms

alpha-KAL, bradykininogenase, callicrein, depot-Padutin, dilminal D, EC 3.4.21.8, EC 3.4.4.21, Fletcher factor, glumorin, HPK, Kal, kallidinogenase, kallikrein, kallikrein B, kallikrein I, kallikrein II, kininogenase, kininogenin, KLK13, KLK2, KLK3, KLK4, KLK5, KLKb1, onokrein P, padreatin, padutin, pancreatic kallikrein, PK, PKA, PKal, PKKS, plasma beta-kallikrein, plasma kallikrein, plasma kallikrein�kinin system, plasma KK, plasma PK, Plasma prekallikrein, plasma prokallikrein, porcine pancreatic kallikrein, PPK, prekallikrein, RPK, serum kallikrein, SmSP1, urinary kallikrein, urokallikrein

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.34 plasma kallikrein

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Results	in table
33	Activating Compound
29	AA Sequence
5	Application
1	CAS Registry Number
4	Cloned(Commentary)
5	Crystallization (Commentary)
6714	Disease/ Diagnostics
3	Expression
23	General Information
2	General Stability
2	IC50 Value
129	Inhibitors
1	kcat/KM [mM/s]
39	Ki Value [mM]
33	KM Value [mM]
36	Localization
27	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
98	Organism
18	PDB ID
14	pH Optimum
1	pI Value
9	Posttranslational Modification
1	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
116	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
223	Substrates and Products (Substrate)
16	Subunits
83	Synonyms
19	Temperature Optimum [°C]
24	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.34 - plasma kallikrein

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163000

Homo sapiens

sedimentation equilibrium, kallikrein II

95363

22000

Homo sapiens

1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains

95360

28000

Homo sapiens

1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains

33000

35000

36000

1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains

95360

41000

Homo sapiens

x * 85000-88000, nonreducing SDS-PAGE, x * 33000-36000, light chain, + x * 41000, heavy chain, reducing SDS-PAGE

651519

43000

Homo sapiens

1 * 43000, 1 * 33000, SDS-PAGE

95361

52000

Homo sapiens

x * 52000 + x * 35000, the purified sample exhibits several bands on SDS-PAGE, and the most intense band is found to be the 52000 Da N-terminal subunit of kallikrein by mass spectrometric analysis, two other minor bands around 35000 Da are both C-terminal subunits of kallikrein

695990

55000

Homo sapiens

x * 88000, prekallikrein, SDS-PAGE, x * 33000, kallikrein light chain, SDS-PAGE, x * 55000, kallikrein heavy chain, SDS-PAGE

653115

79500

Homo sapiens

x * 79500, prekallikrein, calculated from amino acid sequence

732931

82000

Bos taurus

sedimentation equilibrium

95372

85000

Homo sapiens

gel filtration, main peak

653878

86000

Homo sapiens

? * 86000, SDS-PAGE, kallikrein II

95360

86150

Homo sapiens

MALDI TOF mass spectroscopy

88000

95000

98000

? * 98000, SDS-PAGE

99800

sedimentation equilibrium, kallikrein I

95363