Literature summary for 3.4.21.34 extracted from

Vergiliana, J.F.; Asokananthan, N.; Stewart, G.A.
Activation of the plasma kallikrein-kinin system on human lung epithelial cells (2010), Biol. Chem., 391, 1067-1077.

Search for more literature for 3.4.21.34

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	transformed lung epithelial cells express urokinase plasminogen activator receptor, cytokeratin 1 and gC1qR, and assembly of the kininogen-plasma prekallikrein complex on both transformed cell lines and primary human bronchial epithelial cells results in the formation of plasma kallikrein and liberation of bradykinin from kininogen	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	angiotensin II inhibits plasma prekallikrein activation by 11%. 2-Mercaptoethanol, EDTA, benzamidine, 2-aminoethyl benzenesulfonyl fluoride, antipain or leupeptin have little effect on activation, whereas cysteine inhibits activation by approximately 65% at 10 mM. Incubation with 500 mM des-arg9-bradykinin, bradykinin fragment 1-7 or bradykinin fragment 1-5 inhibit plasma prekallikrein activation on A-549 cells by 6%, 20% and 4%, respectively. Plasma prekallikrein activation on A-549 cells is not significantly inhibited by Plummers inhibitor, phosphoramidon, captropril, or apstatin	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
kininogen + H2O	Homo sapiens	-	bradykinin + fragments of kininogen	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Pro-Phe-Arg-4-nitroanilide + H2O	plasma kallikrein-selective substrate	Homo sapiens	D-Pro-Phe-Arg + 4-nitroaniline	-	?
kininogen + H2O	-	Homo sapiens	bradykinin + fragments of kininogen	-	?

Synonyms

Synonyms	Comment	Organism
plasma kallikrein	-	Homo sapiens
PPK	-	Homo sapiens

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Release 2023.1 (January 2023)