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3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Word Map on EC 3.4.14.11

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

Inhibitors

Inhibitors on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
3,4-dichloroisocoumarin
Ca2+
1 mM, 89% residual activity
chloroform
reduced the enzyme activity during purification
diisopropylfluorophosphate
Diprotin A
Diprotin B
IC50: 0.6 mM
iodoacetate
KCl
up to 300 mM, slight activitation. Inhibitory above 500 mM
L-Phe-L-Pro
10 mM, 38% inhibition, mixed-ype inhibition
L-Tyr-L-Pro
10 mM, 28% inhibition, mixed-type inhibition
Mg2+
-
slight inhibition at 0.1-1.0 mM
Na+
up to 300 mM, slight activitation. Inhibitory above 500 mM
o-phenanthroline
10 mM, 50% residual activity
p-chloromercuribenzoate
-
competitive
p-hydroxymercuribenzoate
-
reactivated by DTT
pefabloc
-
1 mM, 35% residual activity
Phenylmethanesulphonyl fluoride
-
0.1 mM, 20 min at 40°C, 40% loss of activity. 1 mM, complete inhibition after 20 min
phenylmethylsulfonyl fluoride
Phenylmethylsulfonylfluoride
-
88.5% inhibition at 1 mM
saxagliptin
inhibitor of human enzyme
Triton X-100
reduces the enzyme activity during purification
Urea
-
2.0 M
Val-pyrrolidide
IC50: 0.03 mM
additional information
-