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3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Word Map on EC 3.4.14.11

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

Temperature Range

Temperature Range on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 50
-
about 55% of activity maximum at 10°C and 50°C
10 - 65
-
10°C: about 55% of activity maximum, 65°C: 34% of activity maximum
20 - 55
-
20°C: about 30% of activity maximum, 55°C: about 40% of activity maximum
20 - 65
-
about 30% of maximal activity at 20°C and at 65°C, hydrolysis of Gly-Pro-7-amido-4-methylcoumarin
30 - 50
-
50% of maximal activity at 30°C, maximum at 40-50°C
35 - 60
-
35°C: about 50% of maximal activity, 60°C: about 30% of maximal activity, hydrolysis of Gly-Pro-7-amido-4-methylcoumarin
40 - 50
-
40°C: 95% of maximal activity, 50°C: 98% of maximal activity
40 - 60
-
40°C: about 15% of maximal activity, 60°C: about 40% of maximal activity
65
8% residual activity