3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Word Map on EC 3.4.14.11

3.4.14.11

lactis

subsp

food industry

cremoris

streptococcus

milk

lactobacillus

lactococci

thermophilus

proline-specific

helveticus

venema

3.4.14.5

pyroglutamyl

microbiol

x-prolyl-dipeptidyl

mutans

diprotin

cystyl

mayo

imino

endopeptidase

exopeptidases

reinke

whey

saxagliptin

casei

synthesis

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

3.4.14.11 Xaa-Pro dipeptidyl-peptidase

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Results	in table
12	Activating Compound
3844	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
2	General Information
4	IC50 Value
101	Inhibitors
12	kcat/KM [mM/s]
2	Ki Value [mM]
37	KM Value [mM]
15	Localization
10	Metals/Ions
31	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
12	Organic Solvent Stability
124	Organism
2	PDB ID
27	pH Optimum
6	pH Range
4	pH Stability
3	pI Value
24	Purification (Commentary)
1	Reaction
1	Reaction Type
83	Reference
15	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
39	Subunits
49	Synonyms
21	Temperature Optimum [°C]
9	Temperature Range [°C]
11	Temperature Stability [°C]
28	Turnover Number [1/s]

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128

Ala-Pro-4-nitroanilide

Lactobacillus helveticus

pH 6.5, 37°C

57.2

Ala-Pro-Arg

Lactobacillus helveticus

pH 6.5, 37°C

181

Arg-Pro 4-nitroanilide

Lactococcus lactis

-

-

133

Arg-Pro-Ala

Lactobacillus helveticus

pH 6.5, 37°C

62.9

Glu-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

2.1

Gly-Ala-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

178

Gly-Pro 4-nitroanilide

Lactococcus lactis

-

-

62.1 - 69.8

Gly-Pro-7-amido-4-methylcoumarin

show

2180

Gly-Pro-Ala

Lactococcus lactis

-

-

46.4

Gly-Pro-Gly-Gly

Lactococcus lactis

-

-

418

His-Pro-Leu

Lactococcus lactis

-

-

670

His-Pro-Tyr

Lactococcus lactis

-

-

26

L-Ala-L-Ala-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

-

57.2

L-Ala-L-Pro-L-Arg

Lactobacillus helveticus

pH 6.5, 37°C

95.9

L-Ala-L-Pro-L-Ser

Lactobacillus helveticus

pH 6.5, 37°C

43.5

L-Ala-L-Pro-L-Tyr

Lactobacillus helveticus

pH 6.5, 37°C

133

L-Arg-L-Pro-L-Ala

Lactobacillus helveticus

pH 6.5, 37°C

199

L-Asp-L-Pro-L-Ala

Lactobacillus helveticus

pH 6.5, 37°C

233

L-Ser-L-Pro-L-Ala

Lactobacillus helveticus

pH 6.5, 37°C

145

L-Tyr-L-Pro-L-Ala

Lactobacillus helveticus

pH 6.5, 37°C

120

Leu-Ala-Pro

Lactococcus lactis

-

-

43.4

Leu-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

17.1

Lys-Ala-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

61.6

Lys-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

78.4

Phe-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

233

Ser-Pro-Ala

Lactobacillus helveticus

pH 6.5, 37°C

145

Tyr-Pro-Ala

Lactobacillus helveticus

pH 6.5, 37°C

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Release 2023.1 (January 2023)