3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

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Results	in table
12	Activating Compound
3844	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
2	General Information
4	IC50 Value
101	Inhibitors
12	kcat/KM [mM/s]
2	Ki Value [mM]
37	KM Value [mM]
15	Localization
10	Metals/Ions
31	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
12	Organic Solvent Stability
124	Organism
2	PDB ID
27	pH Optimum
6	pH Range
4	pH Stability
3	pI Value
24	Purification (Commentary)
1	Reaction
1	Reaction Type
83	Reference
15	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
39	Subunits
49	Synonyms
21	Temperature Optimum [°C]
9	Temperature Range [°C]
11	Temperature Stability [°C]
28	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.05 - 1.53

Ala-Pro-4-nitroanilide

2 entries

0.14

Ala-Pro-Arg

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

754433

0.24

Arg-Pro-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

754433

0.92

Arg-Pro-p-nitroanilide

Lactococcus lactis

-

-

682997

0.0457

Glu-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

0.385

Gly-Ala 4-methylcoumarin 7-amide

Lactococcus lactis

-

-

36263

0.11

Gly-L-Pro 4-nitroanilide

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732739

0.107 - 0.55

Gly-Pro 4-nitroanilide

3 entries

0.089 - 3.1

Gly-Pro-4-nitroanilide

3 entries

0.0141 - 0.2

Gly-Pro-7-amido-4-methylcoumarin

3 entries

1.3 - 1.53

L-Ala-L-Pro 4-nitroanilide

2 entries

0.14

L-Ala-L-Pro-L-Arg

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.53

L-Ala-L-Pro-L-Ser

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.17

L-Ala-L-Pro-L-Tyr

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

1.5

L-Arg-L-Pro 4-nitroanilide

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732739

0.24

L-Arg-L-Pro-L-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

1.23

L-Asp-L-Pro-L-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.54

L-Ser-L-Pro-L-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.12

L-Tyr-L-Pro-L-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.0092

Leu-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

0.088 - 0.231

Lys-Ala-7-amido-4-methylcoumarin

2 entries

0.0146

Lys-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

0.0124

Phe-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

0.54

Ser-Pro-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

754433

0.12

Tyr-Pro-Ala

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

754433

additional information

additional information

3 entries

-

0.05

Ala-Pro-4-nitroanilide

Latilactobacillus sakei

-

pH 7.5, 37°C

647178

1.53

Ala-Pro-4-nitroanilide

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

754433

0.107

Gly-Pro 4-nitroanilide

Lactococcus lactis

-

-

36263

0.28

Gly-Pro 4-nitroanilide

Lactobacillus helveticus

-

-

647170

0.55

Gly-Pro 4-nitroanilide

Aspergillus oryzae

-

-

647168

0.089

Gly-Pro-4-nitroanilide

Streptococcus mutans

Q8DVS2

pH 7.5, 37°C

753589

0.192

Gly-Pro-4-nitroanilide

Latilactobacillus sakei

-

pH 7.5, 37°C

647178

3.1

Gly-Pro-4-nitroanilide

Streptococcus thermophilus

-

pH 7.0, 50°C

36200

0.0141

Gly-Pro-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

0.029

Gly-Pro-7-amido-4-methylcoumarin

Latilactobacillus sakei

-

pH 7.5, 37°C

647178

0.2

Gly-Pro-7-amido-4-methylcoumarin

Lacticaseibacillus casei

-

-

36250

1.3

L-Ala-L-Pro 4-nitroanilide

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732739

1.53

L-Ala-L-Pro 4-nitroanilide

Lactobacillus helveticus

S4TJ23

pH 6.5, 37°C

732344

0.088

Lys-Ala-7-amido-4-methylcoumarin

Latilactobacillus sakei

-

pH 7.5, 37°C

647178

0.231

Lys-Ala-7-amido-4-methylcoumarin

Lactococcus lactis

-

-

36263

additional information

additional information

Lactococcus lactis

-

-

36245

-

additional information

additional information

Lactococcus lactis

-

-

36263

-

additional information

additional information

Fructilactobacillus sanfranciscensis

-

-

665021

-