3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases

                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

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Results	in table
12	Activating Compound
3844	AA Sequence
13	Application
1	CAS Registry Number
6	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
2	General Information
4	IC50 Value
101	Inhibitors
12	kcat/KM [mM/s]
2	Ki Value [mM]
37	KM Value [mM]
15	Localization
10	Metals/Ions
31	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
12	Organic Solvent Stability
124	Organism
2	PDB ID
27	pH Optimum
6	pH Range
4	pH Stability
3	pI Value
24	Purification (Commentary)
1	Reaction
1	Reaction Type
83	Reference
15	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
39	Subunits
49	Synonyms
21	Temperature Optimum [°C]
9	Temperature Range [°C]
11	Temperature Stability [°C]
28	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 7

Lactococcus lactis

-

pH 5.0: 88% of maximal activity, pH 7.0: maximal activity

682997

5 - 9

Lactobacillus helveticus

-

pH 5: about 50% of maximal activity, pH 9: about 60% of maximal activity

36198

5.5 - 8

Lactobacillus helveticus

-

pH 5.5: about 50% of maximal activity, pH 8: about 65% of maximal activity

647170

5.5 - 8.5

Lactococcus lactis

-

pH 5.5: 50% of maximal activity, pH 8.5: activity maximum

36251

6 - 9

Streptococcus thermophilus

-

pH 6.0: about 90% of maximal activity, pH 9.0: about 85% of maximal activity, hydrolysis of Gly-Pro-4-nitroanilide

36200

7

Lactobacillus helveticus

S4TJ23

87% of maximum activity, Na2HPO4/KH2PO4 buffer

732739