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3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Word Map on EC 3.4.14.11

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

Activating Compound

Activating Compound on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
cysteine
-
weak activation
dithiothreitol
-
weak activation
EDTA
-
slight activation at 1.0 mM
glycerol
-
up to 25%, enhances activity
KCl
up to 300 mM, slight activitation. Inhibitory above 500 mM
Na+
up to 300 mM, slight activitation. Inhibitory above 500 mM
Triglyme
-
up to 25%, enhances activity
additional information
-
no significant effect by 2-mercaptoethanol at 1 mM
-