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3.4.14.11: Xaa-Pro dipeptidyl-peptidase

This is an abbreviated version!
For detailed information about Xaa-Pro dipeptidyl-peptidase, go to the full flat file.

Word Map on EC 3.4.14.11

Reaction

Hydrolyses Xaa-Pro-/- bonds to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-/-p-nitroanilide and (sequentially) Tyr-Pro-/-Phe-Pro-/-Gly-Pro-/-Ile =

Synonyms

DAP, LGAS_0712, More, Pep-XP, PepX, PepXP, prolyl dipeptidyl aminopeptidase, X-PDAP, X-Pro dipeptidyl-peptidase, X-prolyl dipeptidyl aminopeptidase, X-prolyl dipeptidyl peptidase, X-prolyl-dipeptidyl aminopeptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.14 Dipeptidyl-peptidases and tripeptidyl-peptidases
                3.4.14.11 Xaa-Pro dipeptidyl-peptidase

Substrates Products

Substrates Products on EC 3.4.14.11 - Xaa-Pro dipeptidyl-peptidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Ala 4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Ala-Pro-Arg + H2O
Ala-Pro + Arg
show the reaction diagram
Ala-Pro-Gly + H2O
Ala-Pro + Gly
show the reaction diagram
Arg-Pro 4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
Arg-Pro-Ala + H2O
Arg-Pro + Ala
show the reaction diagram
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
beta-casein + H2O
?
show the reaction diagram
-
function of the enzyme is to cleave the proline-rich sequence of beta-casein
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
Glu-Pro-7-amido-4-methylcoumarin + H2O
Glu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Ala-7-amido-4-methylcoumarin + H2O
Gly-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-L-Pro 4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro 4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro-4-nitroanilide + H2O
Gly + Pro-4-nitroanilide
show the reaction diagram
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-Pro-Ala + H2O
Gly-Pro + Ala
show the reaction diagram
Gly-Pro-Arg-Pro + H2O
Gly-Pro + Arg-Pro
show the reaction diagram
-
as active as Gly-Pro-4-nitroanilide
-
-
?
Gly-Pro-Gly-Gly + H2O
Gly-Pro + Gly-Gly
show the reaction diagram
-
-
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
His-Pro-Leu + H2O
His-Pro + Leu
show the reaction diagram
-
-
-
-
?
His-Pro-Tyr + H2O
His-Pro + Tyr
show the reaction diagram
-
-
-
-
?
Ile-Pro-Ile + H2O
Ile-Pro + Ile
show the reaction diagram
-
34% of the activity with Gly-Pro-4-nitroanilide
-
-
?
L-Ala-L-Ala-7-amido-4-methylcoumarin + H2O
L-Ala-L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro 4-nitroanilide + H2O
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
L-Ala-L-Pro-4-nitroanilide + H2O
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
L-Ala-L-Pro-L-Arg + H2O
L-Ala-L-Pro + L-Arg
show the reaction diagram
L-Ala-L-Pro-L-Ser + H2O
L-Ala-L-Pro + L-Ser
show the reaction diagram
L-Ala-L-Pro-L-Tyr + H2O
L-Ala-L-Pro + L-Tyr
show the reaction diagram
L-Arg-L-Pro 4-nitroanilide + H2O
L-Arg-L-Pro + 4-nitroaniline
show the reaction diagram
L-Arg-L-Pro-L-Ala + H2O
L-Arg-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
L-Asp-L-Pro-L-Ala + H2O
L-Asp-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
L-Ser-L-Pro-L-Ala + H2O
L-Ser-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
L-Tyr-L-Pro-L-Ala + H2O
L-Tyr-L-Pro + L-Ala
show the reaction diagram
-
-
-
?
Leu-Ala-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
Leu-Pro-7-amido-4-methylcoumarin + H2O
Leu-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
Lys-Ala-Val-Pro-Tyr-Pro-Gln + H2O
?
show the reaction diagram
-
fragment 176-182 of beta-casein
-
-
?
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Pro-p-nitroanilide + H2O
Lys-Pro + p-nitroaniline
show the reaction diagram
-
85% of the activity with Arg-Pro-p-nitroanilide
-
-
?
Phe-Pro-7-amido-4-methylcoumarin + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Pro-Phe-Pro-Gly-Pro-Ile + H2O
Pro-Phe + Pro-Gly-Pro-Ile
show the reaction diagram
-
-
-
-
?
Ser-Pro-Ala + H2O
Ser-Pro + Ala
show the reaction diagram
Tyr-Pro-Ala + H2O
Tyr-Pro + Ala
show the reaction diagram
Tyr-Pro-Phe + H2O
Tyr-Pro + Phe
show the reaction diagram
-
-
-
-
?
Tyr-Pro-Phe-Pro-Gly-Pro-Ile + H2O
Tyr-Pro + Phe-Pro-Gly-Pro-Ile
show the reaction diagram
-
i.e. BCM-7, beta-casomorphin 7
-
-
?
Val-Pro-Leu + H2O
Val-Pro + Leu
show the reaction diagram
-
83% of the activity with Gly-Pro-nitroanilide
-
-
?
VYPFPGPIPN + H2O
?
show the reaction diagram
additional information
?
-