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3.2.2.23: DNA-formamidopyrimidine glycosylase

This is an abbreviated version!
For detailed information about DNA-formamidopyrimidine glycosylase, go to the full flat file.

Word Map on EC 3.2.2.23

Reaction

DNA containing ring-opened N7-methylguanine
+
H2O
=
deguanylated DNA
 +
2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine

Synonyms

2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine-DNA glycosylase, 8-hydroxyguanine endonuclease, 8-oxoguanine DNA glycosylase, 8-oxoguanine-DNA glycosylase, deoxyribonucleate glycosidase, DNA glycohydrolase (releasing 2,6-diamino-4-hydroxy-5-(N-methyl)-formamidopyrimidine), DNA glycosylase, endonuclease VIII-like DNA glycosylase, Fapy DNA glycosylase, Fapy-DNA glycosylase, formamidopyrimidineDNA glycosylase, formamidopyrimidine DNA glycosylase, formamidopyrimidine glycosylase, formamidopyrimidine-DNA glycosyl hydrolase, formamidopyrimidine-DNA glycosylase, formamidopyrimidine-N-glycosylase, FPG, Fpg protein, FPG-1, FPG-2, Fpg-L, glycosidase, deoxyribonucleate formamidopyrimidine, More, Mtb-Fpg1, MutM, MutM1, NEH1, NEH2, Nei, NEIL1, NEIL3, OGG1

ECTree

     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.23 DNA-formamidopyrimidine glycosylase

Reference

topprint

Reference on EC 3.2.2.23 - DNA-formamidopyrimidine glycosylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boiteux, S.; O'Connor, T.R.; Laval, J.
Formamidopyrimidine-DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein
EMBO J.
6
3177-3183
1987
Escherichia coli, Escherichia coli HB1100
Manually annotated by BRENDA team
Tchou, J.; Grollman, A.P.
The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site
J. Biol. Chem.
270
11671-11677
1995
Escherichia coli, Escherichia coli JM109
Manually annotated by BRENDA team
Tchou, J.; Bodepudi, V.; Shibutani, S.; Antoshechkin, I.; Miller, J.; Grollman, A.P.; Johnson, F.
Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA
J. Biol. Chem.
269
15318-15324
1994
Escherichia coli
Manually annotated by BRENDA team
Tchou, J.; Kasai, H.; Chung, M.H.; Laval, J.; Grollman, A.P.; Nishimura, S.
8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity
Proc. Natl. Acad. Sci. USA
88
4690-4694
1991
Escherichia coli
Manually annotated by BRENDA team
O'Connor, T.R.; Laval, J.
Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites
Proc. Natl. Acad. Sci. USA
86
5222-5226
1989
Escherichia coli
Manually annotated by BRENDA team
Bailly, V.; Verly, W.G.; O'Connor, T.; Laval, J.
Mechanism of DNA strand nicking at apurinic/apyrimidinic sites by Escherichia coli [formamidopyrimidine]DNA glycosylase
Biochem. J.
262
581-589
1989
Escherichia coli
Manually annotated by BRENDA team
Chetsanga, C.J.; Lozon, M.; Makaroff, C.; Savage, L.
Purification and characterization of Escherichia coli formamidopyrimidine-DNA glycosylase that excises damaged 7-methylguanine from deoxyribonucleic acid
Biochemistry
20
5201-5207
1981
Escherichia coli
Manually annotated by BRENDA team
Hatahet, Z.; Kow, Y.W.; Purmal, A.A.; Cunningham, R.P.; Wallace, S.S.
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase
J. Biol. Chem.
269
18814-18820
1994
Escherichia coli
Manually annotated by BRENDA team
Serre, L.; Pereira de Jesus, K.; Boiteux, S.; Zelwer, C.; Castaing, B.
Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA
EMBO J.
21
2854-2865
2002
Lactococcus lactis
Manually annotated by BRENDA team
Gilboa, R.; Zharkov, D.O.; Golan, G.; Fernandes, A.S.; Gerchman, S.E.; Matz, E.; Kycia, J.H.; Grollman, A.P.; Shoham, G.
Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA
J. Biol. Chem.
277
19811-19816
2002
Escherichia coli
Manually annotated by BRENDA team
Buchko, G.W.; Hess, N.J.; Bandaru, V.; Wallace, S.S.; Kennedy, M.A.
Spectroscopic studies of zinc(II)- and cobalt(II)-associated Escherichia coli formamidopyrimidine-DNA glycosylase: extended X-ray absorption fine structure evidence for a metal-binding domain
Biochemistry
39
12441-12449
2000
Escherichia coli
Manually annotated by BRENDA team
Duwat, P.; de Oliveira, R.; Ehrlich, S.D.; Boiteux, S.
Repair of oxidative DNA damage in gram-positive bacteria: the Lactococcus lactis Fpg protein
Microbiology
141
411-417
1995
Lactococcus lactis (P42371), Lactococcus lactis
Manually annotated by BRENDA team
Kuznetsov, S.V.; Sidorkina, O.M.; Jurado, J.; Bazin, M.; Tauc, P.; Brochon, J.C.; Laval, J.; Santus, R.
Effect of single mutations on the structural dynamics of a DNA repair enzyme, the Escherichia coli formamidopyrimidine-DNA glycosylase. A fluorescence study using tryptophan residues as reporter groups
Eur. J. Biochem.
253
413-420
1998
Escherichia coli, Escherichia coli BH20
Manually annotated by BRENDA team
Sidorkina, O.; Dizdaroglu, M.; Laval, J.
Effect of single mutations on the specificity of Escherichia coli FPG protein for excision of purine lesions from DNA damaged by free radicals
Free Radic. Biol. Med.
31
816-823
2001
Escherichia coli
Manually annotated by BRENDA team
Rabow, L.E.; Kow, Y.W.
Mechanism of action of base release by Escherichia coli Fpg protein: Role of lysine 155 in catalysis
Biochemistry
36
5084-5096
1997
Escherichia coli (P50465), Escherichia coli
Manually annotated by BRENDA team
Rabow, L.; Venkataraman, R.; Kow, Y.W.
Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase: Role of K155 in substrate binding and product release
Prog. Nucleic Acid Res. Mol. Biol.
68
223-234
2001
Escherichia coli
Manually annotated by BRENDA team
Gao, M.J.; Murphy, T.M.
Alternative forms of formamidopyrimidine-DNA glycosylase from Arabidopsis thaliana
Photochem. Photobiol.
73
128-134
2001
Arabidopsis thaliana (O80358), Arabidopsis thaliana
Manually annotated by BRENDA team
D'Ham, C.; Romieu, A.; Jaquinod, M.; Gasparutto, D.; Cadet, J.
Excision of 5,6-dihydroxy-5,6-dihydrothymine, 5,6-dihydrothymine, and 5-hydroxycytosine from defined sequence oligonucleotides by Escherichia coli endonuclease III and Fpg proteins: Kinetic and mechanistic aspects
Biochemistry
38
3335-3344
1999
Escherichia coli
Manually annotated by BRENDA team
Sentuerker, S.; Bauche, C.; Laval, J.; Dizdaroglu, M.
Substrate specificity of Deinococcus radiodurans Fpg protein
Biochemistry
38
9435-9439
1999
Deinococcus radiodurans
Manually annotated by BRENDA team
Sidorkina, O.M.; Laval, J.
Role of lysine-57 in the catalytic activities of Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg protein)
Nucleic Acids Res.
26
5351-5357
1998
Escherichia coli, Escherichia coli BH20
Manually annotated by BRENDA team
Minetti, C.A.S.A.; Remeta, D.P.; Zharkov, D.O.; Plum, G.E.; Johnson, F.; Grollman, A.P.; Breslauer, K.J.
Energetics of lesion recognition by a DNA repair protein: Thermodynamic characterization of formamidopyrimidine-glycosylase (Fpg) interactions with damaged DNA duplexes
J. Mol. Biol.
328
1047-1060
2003
Escherichia coli, Escherichia coli B834 (DE3)
Manually annotated by BRENDA team
Fedorova, O.S.; Nevinsky, G.A.; Koval, V.V.; Ishchenko, A.A.; Vasilenko, N.L.; Douglas, K.T.
Stopped-flow kinetic studies of the interaction between Escherichia coli Fpg protein and DNA substrates
Biochemistry
41
1520-1528
2002
Escherichia coli
Manually annotated by BRENDA team
Asagoshi, K.; Yamada, T.; Terato, H.; Ohyama, Y.; Monden, Y.; Arai, T.; Nishimura, S.; Aburatani, H.; Lindahl, T.; Ide, H.
Distinct repair activities of human 7,8-dihydro-8-oxoguanine DNA glycosylase and formamidopyrimidine DNA glycosylase for formamidopyrimidine and 7,8-dihydro-8-oxoguanine
J. Biol. Chem.
275
4956-4964
2000
Escherichia coli
Manually annotated by BRENDA team
Sidorkina, O.M.; Laval, J.
Role of the N-terminal proline residue in the catalytic activities of the Escherichia coli Fpg protein
J. Biol. Chem.
275
9924-9929
2000
Escherichia coli
Manually annotated by BRENDA team
Hazra, T.K.; Izumi, T.; Boldogh, I.; Imhoff, B.; Kow, Y.W.; Jaruga, P.; Dizdaroglu, M.; Mitra, S.
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA
Proc. Natl. Acad. Sci. USA
99
3523-3528
2002
Homo sapiens (Q969S2), Homo sapiens (Q96FI4)
Manually annotated by BRENDA team
Murphy, T.M.; George, A.
A comparison of two DNA base excision repair glycosylases from Arabidopsis thaliana
Biochem. Biophys. Res. Commun.
329
869-872
2005
Arabidopsis thaliana
Manually annotated by BRENDA team
Perlow-Poehnelt, R.A.; Zharkov, D.O.; Grollman, A.P.; Broyde, S.
Substrate discrimination by formamidopyrimidine-DNA glycosylase: distinguishing interactions within the active site
Biochemistry
43
16092-16105
2004
Escherichia coli (P05523), Escherichia coli
Manually annotated by BRENDA team
Wozniak, K.; Blasiak, J.
Nickel impairs the repair of UV- and MNNG-damaged DNA
Cell. Mol. Biol. Lett.
9
83-94
2004
Homo sapiens
Manually annotated by BRENDA team
Buchko, G.W.; McAteer, K.; Wallace, S.S.; Kennedy, M.A.
Solution-state NMR investigation of DNA binding interactions in Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg): a dynamic description of the DNA/protein interface
DNA Repair
4
327-339
2005
Escherichia coli
Manually annotated by BRENDA team
Zaika, E.I.; Perlow, R.A.; Matz, E.; Broyde, S.; Gilboa, R.; Grollman, A.P.; Zharkov, D.O.
Substrate discrimination by formamidopyrimidine-DNA glycosylase: a mutational analysis
J. Biol. Chem.
279
4849-4861
2004
Escherichia coli
Manually annotated by BRENDA team
Koval, V.V.; Kuznetsov, N.A.; Zharkov, D.O.; Ishchenko, A.A.; Douglas, K.T.; Nevinsky, G.A.; Fedorova, O.S.
Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase
Nucleic Acids Res.
32
926-935
2004
Escherichia coli
Manually annotated by BRENDA team
Reddy, P.; Jaruga, P.; O'Connor, T.; Rodriguez, H.; Dizdaroglu, M.
Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase
Protein Expr. Purif.
34
126-133
2004
Escherichia coli
Manually annotated by BRENDA team
Amara, P.; Serre, L.; Castaing, B.; Thomas, A.
Insights into the DNA repair process by the formamidopyrimidine-DNA glycosylase investigated by molecular dynamics
Protein Sci.
13
2009-2021
2004
Geobacillus stearothermophilus, Lactococcus lactis
Manually annotated by BRENDA team
Song, K.; Hornak, V.; de Los Santos, C.; Grollman, A.P.; Simmerling, C.
Computational analysis of the mode of binding of 8-oxoguanine to formamidopyrimidine-DNA glycosylase
Biochemistry
45
10886-10894
2006
Geobacillus stearothermophilus (P84131), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Harbut, M.B.; Meador, M.; Dodson, M.L.; Lloyd, R.S.
Modulation of the turnover of formamidopyrimidine DNA glycosylase
Biochemistry
45
7341-7346
2006
Escherichia coli (P05523), Escherichia coli
Manually annotated by BRENDA team
Kuznetsov, N.A.; Koval, V.V.; Zharkov, D.O.; Vorobjev, Y.N.; Nevinsky, G.A.; Douglas, K.T.; Fedorova, O.S.
Pre-steady-state kinetic study of substrate specificity of Escherichia coli formamidopyrimidine--DNA glycosylase
Biochemistry
46
424-435
2007
Escherichia coli (P05523), Escherichia coli
Manually annotated by BRENDA team
Krishnamurthy, N.; Muller, J.G.; Burrows, C.J.; David, S.S.
Unusual structural features of hydantoin lesions translate into efficient recognition by Escherichia coli Fpg
Biochemistry
46
9355-9365
2007
Escherichia coli
Manually annotated by BRENDA team
Jain, R.; Kumar, P.; Varshney, U.
A distinct role of formamidopyrimidine DNA glycosylase (MutM) in down-regulation of accumulation of G, C mutations and protection against oxidative stress in mycobacteria
DNA Repair
6
1774-1785
2007
Mycolicibacterium smegmatis
Manually annotated by BRENDA team
Paul, S.; Gros, L.; Laval, J.; Sutherland, B.M.
Expression of the E. coli fpg protein in CHO cells lowers endogenous oxypurine clustered damage levels and decreases accumulation of endogenous Hprt mutations
Environ. Mol. Mutagen.
47
311-319
2006
Escherichia coli
Manually annotated by BRENDA team
Ropolo, M.; Degan, P.; Foresta, M.; DErrico, M.; Lasiglie, D.; Dogliotti, E.; Casartelli, G.; Zupo, S.; Poggi, A.; Frosina, G.
Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase
Free Radic. Biol. Med.
42
1807-1817
2007
Escherichia coli
Manually annotated by BRENDA team
Ropolo, M.; Geroldi, A.; Degan, P.; Andreotti, V.; Zupo, S.; Poggi, A.; Reed, A.; Kelley, M.R.; Frosina, G.
Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein
Int. J. Cancer
118
1628-1634
2006
Escherichia coli
Manually annotated by BRENDA team
Song, K.; Kelso, C.; de los Santos, C.; Grollman, A.P.; Simmerling, C.
Molecular simulations reveal a common binding mode for glycosylase binding of oxidatively damaged DNA lesions
J. Am. Chem. Soc.
129
14536-14537
2007
Geobacillus stearothermophilus
Manually annotated by BRENDA team
Hamm, M.L.; Gill, T.J.; Nicolson, S.C.; Summers, M.R.
Substrate specificity of Fpg (MutM) and hOGG1, two repair glycosylases
J. Am. Chem. Soc.
129
7724-7725
2007
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Rogacheva, M.; Ishchenko, A.; Saparbaev, M.; Kuznetsova, S.; Ogryzko, V.
High resolution characterization of formamidopyrimidine-DNA glycosylase interaction with its substrate by chemical cross-linking and mass spectrometry using substrate analogs
J. Biol. Chem.
281
32353-32365
2006
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Smith, C.C.; ODonovan, M.R.; Martin, E.A.
hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII
Mutagenesis
21
185-190
2006
Escherichia coli, Homo sapiens
Manually annotated by BRENDA team
Dusinska, M.; Dzupinkova, Z.; Wsolova, L.; Harrington, V.; Collins, A.R.
Possible involvement of XPA in repair of oxidative DNA damage deduced from analysis of damage, repair and genotype in a human population study
Mutagenesis
21
205-211
2006
Homo sapiens
Manually annotated by BRENDA team
Shu, J.; Schellhorn, H.E.; Murphy, T.M.
Stationary phase-induction of G->T mutations in Escherichia coli
Mutat. Res.
596
106-112
2006
Escherichia coli
Manually annotated by BRENDA team
Poplawski, T.; Arabski, M.; Kozirowska, D.; Blasinska-Morawiec, M.; Morawiec, Z.; Morawiec-Bajda, A.; Klupinska, G.; Jeziorski, A.; Chojnacki, J.; Blasiak, J.
DNA damage and repair in gastric cancer - A correlation with the hOGG1 and RAD51 genes polymorphisms
Mutat. Res.
601
83-91
2006
Homo sapiens
Manually annotated by BRENDA team
Lacoste, S.; Castonguay, A.; Drouin, R.
Repair kinetics of specific types of nitroso-induced DNA damage using the comet assay in human cells
Mutat. Res.
624
18-30
2007
Homo sapiens
Manually annotated by BRENDA team
Sliwinski, T.; Rozej, W.; Morawiec-Bajda, A.; Morawiec, Z.; Reiter, R.; Blasiak, J.
Protective action of melatonin against oxidative DNA damage-Chemical inactivation versus base-excision repair
Mutat. Res.
634
220-227
2007
Homo sapiens
Manually annotated by BRENDA team
Morawiec, Z.; Janik, K.; Kowalski, M.; Stetkiewicz, T.; Szaflik, J.; Morawiec-Bajda, A.; Sobczuk, A.; Blasiak, J.
DNA damage and repair in children with Downs syndrome
Mutat. Res.
637
118-123
2008
Homo sapiens
Manually annotated by BRENDA team
Minetti, C.A.; Remeta, D.P.; Breslauer, K.J.
A continuous hyperchromicity assay to characterize the kinetics and thermodynamics of DNA lesion recognition and base excision
Proc. Natl. Acad. Sci. USA
105
70-75
2008
Escherichia coli
Manually annotated by BRENDA team
Martinez-Alfaro, M.; Palma-Tirado, L.; Sandoval-Zapata, F.; Carabez-Trejo, A.
Correlation between formamidopyrimidine DNA glycosylase (Fpg)-sensitive sites determined by a comet assay, increased MDA, and decreased glutathione during long exposure to thinner inhalation
Toxicol. Lett.
163
198-205
2006
Rattus norvegicus
Manually annotated by BRENDA team
Fracasso, M.E.; Doria, D.; Franceschetti, P.; Perbellini, L.; Romeo, L.
DNA damage and repair capacity by comet assay in lymphocytes of white-collar active smokers and passive smokers (non- and ex-smokers) at workplace
Toxicol. Lett.
167
131-141
2006
Homo sapiens
Manually annotated by BRENDA team
Murphy, T.M.; Guo, Y.Y.
Antimutagenic specificities of two plant glycosylases, oxoguanine glycosylase and formamidopyrimidine glycosylase, assayed in vivo
Biochem. Biophys. Res. Commun.
392
335-339
2010
Arabidopsis thaliana (O80358), Arabidopsis thaliana
Manually annotated by BRENDA team
Grin, I.R.; Konorovsky, P.G.; Nevinsky, G.A.; Zharkov, D.O.
Heavy metal ions affect the activity of DNA glycosylases of the fpg family
Biochemistry (Moscow)
74
1253-1259
2009
Homo sapiens
Manually annotated by BRENDA team
Kuznetsov, N.A.; Zharkov, D.O.; Koval, V.V.; Buckle, M.; Fedorova, O.S.
Reversible chemical step and rate-limiting enzyme regeneration in the reaction catalyzed by formamidopyrimidine-DNA glycosylase
Biochemistry
48
11335-11343
2009
Escherichia coli
Manually annotated by BRENDA team
Kathe, S.D.; Barrantes-Reynolds, R.; Jaruga, P.; Newton, M.R.; Burrows, C.J.; Bandaru, V.; Dizdaroglu, M.; Bond, J.P.; Wallace, S.S.
Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases
DNA Repair
8
643-653
2009
Candida albicans, Arabidopsis thaliana (Q88AH6), Arabidopsis thaliana
Manually annotated by BRENDA team
Chan, M.K.; Ocampo-Hafalla, M.T.; Vartanian, V.; Jaruga, P.; Kirkali, G.; Koenig, K.L.; Brown, S.; Lloyd, R.S.; Dizdaroglu, M.; Teebor, G.W.
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA
DNA Repair
8
786-794
2009
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Sidorenko, V.S.; Grollman, A.P.; Jaruga, P.; Dizdaroglu, M.; Zharkov, D.O.
Substrate specificity and excision kinetics of natural polymorphic variants and phosphomimetic mutants of human 8-oxoguanine-DNA glycosylase
FEBS J.
276
5149-5162
2009
Homo sapiens (O15527), Homo sapiens
Manually annotated by BRENDA team
Olsen, I.; Balasingham, S.V.; Davidsen, T.; Debebe, E.; Rodland, E.A.; van Soolingen, D.; Kremer, K.; Alseth, I.; Tonjum, T.
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol. Med. Microbiol.
56
151-161
2009
Mycobacterium tuberculosis (P9WNC3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNC3), Mycobacterium tuberculosis H37Rv
Manually annotated by BRENDA team
Foresta, M.; Ropolo, M.; Degan, P.; Pettinati, I.; Kow, Y.W.; Damonte, G.; Poggi, A.; Frosina, G.
Defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III
Free Radic. Biol. Med.
48
681-690
2010
Escherichia coli
Manually annotated by BRENDA team
Muftuoglu, M.; de Souza-Pinto, N.C.; Dogan, A.; Aamann, M.; Stevnsner, T.; Rybanska, I.; Kirkali, G.; Dizdaroglu, M.; Bohr, V.A.
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase
J. Biol. Chem.
284
9270-9279
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Koval, V.V.; Kuznetsov, N.A.; Ishchenko, A.A.; Saparbaev, M.K.; Fedorova, O.S.
Real-time studies of conformational dynamics of the repair enzyme E. coli formamidopyrimidine-DNA glycosylase and its DNA complexes during catalytic cycle
Mutat. Res.
685
3-10
2010
Escherichia coli
Manually annotated by BRENDA team
Liu, M.; Bandaru, V.; Bond, J.P.; Jaruga, P.; Zhao, X.; Christov, P.P.; Burrows, C.J.; Rizzo, C.J.; Dizdaroglu, M.; Wallace, S.S.
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo
Proc. Natl. Acad. Sci. USA
107
4925-4930
2010
Mus musculus
Manually annotated by BRENDA team
Jaruga, P.; Xiao, Y.; Vartanian, V.; Lloyd, R.S.; Dizdaroglu, M.
Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines
Biochemistry
49
1053-1055
2010
Mus musculus
Manually annotated by BRENDA team
Schalow, B.J.; Courcelle, C.T.; Courcelle, J.
Escherichia coli Fpg glycosylase is nonrendundant and required for the rapid global repair of oxidized purine and pyrimidine damage in vivo
J. Mol. Biol.
410
183-193
2011
Escherichia coli, Escherichia coli SR108
Manually annotated by BRENDA team
Le Bihan, Y.V.; Angeles Izquierdo, M.; Coste, F.; Aller, P.; Culard, F.; Gehrke, T.H.; Essalhi, K.; Carell, T.; Castaing, B.
5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases
Nucleic Acids Res.
39
6277-6290
2011
Lactococcus lactis
Manually annotated by BRENDA team
Dunn, A.R.; Kad, N.M.; Nelson, S.R.; Warshaw, D.M.; Wallace, S.S.
Single Qdot-labeled glycosylase molecules use a wedge amino acid to probe for lesions while scanning along DNA
Nucleic Acids Res.
39
7487-7498
2011
Escherichia coli
Manually annotated by BRENDA team
Reddy, P.T.; Jaruga, P.; Nelson, B.C.; Lowenthal, M.; Dizdaroglu, M.
Stable isotope-labeling of DNA repair proteins, and their purification and characterization
Protein Expr. Purif.
78
94-101
2011
Escherichia coli
Manually annotated by BRENDA team
Rana, J.; Huang, H.
Actions of the Klenow fragment of DNA polymerase I and some DNA glycosylases on chemically stable analogues of N7-methyl-2-deoxyguanosine
Bioorg. Med. Chem.
21
6886-6892
2013
Escherichia coli
Manually annotated by BRENDA team
Duclos, S.; Aller, P.; Jaruga, P.; Dizdaroglu, M.; Wallace, S.S.; Doublie, S.
Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine
DNA Repair
11
714-725
2012
Arabidopsis thaliana (O80358), Arabidopsis thaliana
Manually annotated by BRENDA team
Kain, J.; Karlsson, H.L.; Moeller, L.
DNA damage induced by micro- and nanoparticles - interaction with FPG influences the detection of DNA oxidation in the comet assay
Mutagenesis
27
491-500
2012
Escherichia coli
Manually annotated by BRENDA team
Kuznetsov, N.A.; Vorobjev, Y.N.; Krasnoperov, L.N.; Fedorova, O.S.
Thermodynamics of the multi-stage DNA lesion recognition and repair by formamidopyrimidine-DNA glycosylase using pyrrolocytosine fluorescence--stopped-flow pre-steady-state kinetics
Nucleic Acids Res.
40
7384-7392
2012
Escherichia coli
Manually annotated by BRENDA team
Foresta, M.; Izzotti, A.; La Maestra, S.; Micale, R.; Poggi, A.; Vecchio, D.; Frosina, G.
Accelerated repair and reduced mutagenicity of DNA damage induced by cigarette smoke in human bronchial cells transfected with E.coli formamidopyrimidine DNA glycosylase
PLoS ONE
9
e87984
2014
Escherichia coli
Manually annotated by BRENDA team
Prakash, A.; Doublie, S.; Wallace, S.S.
The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage
Prog. Mol. Biol. Transl. Sci.
110
71-91
2012
Thermus thermophilus (O50606), Escherichia coli (P05523), Lactococcus lactis (P42371), Geobacillus stearothermophilus (P84131), Thermus thermophilus DSM 579 (O50606)
Manually annotated by BRENDA team
Ondovcik, S.L.; Preston, T.J.; McCallum, G.P.; Wells, P.G.
Expression of human oxoguanine glycosylase 1 or formamidopyrimidine glycosylase in human embryonic kidney 293 cells exacerbates methylmercury toxicity in vitro
Toxicol. Appl. Pharmacol.
271
41-48
2013
Homo sapiens
Manually annotated by BRENDA team
Song, J.; Yin, F.; Li, X.; Dong, N.; Zhu, Y.; Shao, Y.; Chen, B.; Jiang, W.; Li, C.Z.
Sensitive detection of formamidopyrimidine-DNA glycosylase activity based on target-induced self-primed rolling circle amplification and magnetic nanoprobes
Analyst
143
1593-1598
2018
Homo sapiens
Manually annotated by BRENDA team
Le Meur, R.; Culard, F.; Nadan, V.; Goffinont, S.; Coste, F.; Guerin, M.; Loth, K.; Landon, C.; Castaing, B.
The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase
Biochem. J.
471
13-23
2015
Escherichia coli (P05523)
Manually annotated by BRENDA team
Sowlati-Hashjin, S.; Wetmore, S.D.
Structural insight into the discrimination between 8-oxoguanine glycosidic conformers by DNA repair rnzymes A molecular dynamics study of human oxoguanine glycosylase 1 and formamidopyrimidine-DNA glycosylase
Biochemistry
57
1144-1154
2018
Geobacillus stearothermophilus (P84131)
Manually annotated by BRENDA team
Popov, A.V.; Endutkin, A.V.; Vorobjev, Y.N.; Zharkov, D.O.
Molecular dynamics simulation of the opposite-base preference and interactions in the active site of formamidopyrimidine-DNA glycosylase
BMC Struct. Biol.
17
005
2017
Lactococcus lactis (P42371), Lactococcus lactis
Manually annotated by BRENDA team
Kiruba, G.S.; Xu, J.; Zelikson, V.; Lee, J.K.
Gas-phase studies of formamidopyrimidine glycosylase (Fpg) substrates
Chemistry
22
3881-3890
2016
Escherichia coli
Manually annotated by BRENDA team
Endutkin, A.V.; Koptelov, S.S.; Popov, A.V.; Torgasheva, N.A.; Lomzov, A.A.; Tsygankova, A.R.; Skiba, T.V.; Afonnikov, D.A.; Zharkov, D.O.
Residue coevolution reveals functionally important intramolecular interactions in formamidopyrimidine-DNA glycosylase
DNA Repair
69
24-33
2018
Escherichia coli (P05523), Escherichia coli
Manually annotated by BRENDA team
Minko, I.G.; Christov, P.P.; Li, L.; Stone, M.P.; McCullough, A.K.; Lloyd, R.S.
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3
DNA Repair
73
49-54
2019
Homo sapiens (Q96FI4), Homo sapiens, Mus musculus (Q8K203), Mus musculus
Manually annotated by BRENDA team
Arantes, L.S.; Nova, L.G.; Resende, B.C.; Bitar, M.; Coelho, I.E.; Miyoshi, A.; Azevedo, V.A.; Lara Dos Santos, L.; Machado, C.R.; de Oliveira Lopes, D.
The Corynebacterium pseudotuberculosis genome contains two formamidopyrimidine-DNA glycosylase enzymes, only one of which recognizes and excises 8-oxoguanine lesion
Gene
575
233-243
2016
Corynebacterium pseudotuberculosis (D9QB78), Corynebacterium pseudotuberculosis, Corynebacterium pseudotuberculosis 231 (D9QB78)
Manually annotated by BRENDA team
Li, H.; Endutkin, A.V.; Bergonzo, C.; Campbell, A.J.; de los Santos, C.; Grollman, A.; Zharkov, D.O.; Simmerling, C.
A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase
Nucleic Acids Res.
44
683-694
2016
Escherichia coli (P05523), Geobacillus stearothermophilus (P84131)
Manually annotated by BRENDA team