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Literature summary for 3.2.2.23 extracted from

  • Foresta, M.; Ropolo, M.; Degan, P.; Pettinati, I.; Kow, Y.W.; Damonte, G.; Poggi, A.; Frosina, G.
    Defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III (2010), Free Radic. Biol. Med., 48, 681-690.
    View publication on PubMed
Search for more literature for 3.2.2.23

Cloned(Commentary)

Cloned (Comment) Organism
expression of EGFP-tagged enzyme in HEK-293T cells. Transformation of primary human fibroblasts of a Cockayne syndrome patient using SV40, expression of FPG in 5-hydroxy-2'-deoxycytidine repair defective human cells complements the disorder and leads to stable correction of the delayed removal of both oxidized purines and oxidized pyrimidines in the cells, detailed overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt oligodeoxynucleotide + H2O Escherichia coli
-
 2,6-diamino-4-hydroxy-5-formamidopyrimidine + Cyt oligodeoxynucleotide
-
 ?
8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O Escherichia coli
-
 8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide
-
 ?
additional information Escherichia coli defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells is complementated by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,6-diamino-4-hydroxy-5-formamidopyrimidine:Cyt oligodeoxynucleotide + H2O
-
 Escherichia coli 2,6-diamino-4-hydroxy-5-formamidopyrimidine + Cyt oligodeoxynucleotide
-
 ?
8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide + H2O
-
 Escherichia coli 8-oxo-7,8-dihydroguanine + Cyt oligodeoxynucleotide
-
 ?
additional information defective repair of 5-hydroxy-2-deoxycytidine in Cockayne syndrome cells is complementated by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III Escherichia coli ?
-
 ?

Synonyms

Synonyms Comment Organism
formamidopyrimidine DNA glycosylase
-
 Escherichia coli
FPG
-
 Escherichia coli