3.2.2.23: DNA-formamidopyrimidine glycosylase

This is an abbreviated version!
For detailed information about DNA-formamidopyrimidine glycosylase, go to the full flat file.

Word Map on EC 3.2.2.23

3.2.2.23

strand

comet

glycosylases

genotoxic

purine

single-stranded

abasic

duplex

fpg-sensitive

thymine

excises

7,8-dihydro-8-oxoguanine

ape1

ring-opened

8-oxo-7,8-dihydroguanine

8-oxodg

endonucleases

8-oxo-7,8-dihydro-2'-deoxyguanosine

5-hydroxyuracil

micronucleus

transversions

neils

alkali-labile

biomonitoring

3-methyladenine-dna

mispairs

interstrand

lesion-specific

spiroiminodihydantoin

bromate

medicine

2'-deoxyguanosine

klenow

ap-endonuclease

uvrabc

miscoding

base-excision

apurinic

8-oxo-2'-deoxyguanosine

monoadducts

dihydrouracil

enzyme-modified

unhook

mutyh

endoiii

analysis

Reaction

DNA containing ring-opened N7-methylguanine

Synonyms

2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine-DNA glycosylase, 8-hydroxyguanine endonuclease, 8-oxoguanine DNA glycosylase, 8-oxoguanine-DNA glycosylase, deoxyribonucleate glycosidase, DNA glycohydrolase (releasing 2,6-diamino-4-hydroxy-5-(N-methyl)-formamidopyrimidine), DNA glycosylase, endonuclease VIII-like DNA glycosylase, Fapy DNA glycosylase, Fapy-DNA glycosylase, formamidopyrimidineDNA glycosylase, formamidopyrimidine DNA glycosylase, formamidopyrimidine glycosylase, formamidopyrimidine-DNA glycosyl hydrolase, formamidopyrimidine-DNA glycosylase, formamidopyrimidine-N-glycosylase, FPG, Fpg protein, FPG-1, FPG-2, Fpg-L, glycosidase, deoxyribonucleate formamidopyrimidine, More, Mtb-Fpg1, MutM, MutM1, NEH1, NEH2, Nei, NEIL1, NEIL3, OGG1

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.23 DNA-formamidopyrimidine glycosylase

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Results	in table
3	Activating Compound
26701	AA Sequence
13	Application
1	CAS Registry Number
26	Cloned(Commentary)
12	Crystallization (Commentary)
417	Disease/ Diagnostics
23	General Information
5	General Stability
3	IC50 Value
18	Inhibitors
3	Ki Value [mM]
89	KM Value [mM]
7	Localization
22	Metals/Ions
23	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
282	Organism
69	PDB ID
20	pH Optimum
2	pI Value
1	Posttranslational Modification
73	Protein Variants
25	Purification (Commentary)
19	Reaction
1	Reaction Type
107	Reference
37	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
297	Substrates and Products (Substrate)
34	Subunits
104	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
11	Temperature Stability [°C]
66	Turnover Number [1/s]

Turnover Number

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Turnover Number on EC 3.2.2.23 - DNA-formamidopyrimidine glycosylase

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0.0065 - 0.0283

13mer oligonucleotide duplex containing 8-oxoguanine

10 entries

0.07 - 1.7

23mer oligonucleotide duplex containing 8-oxoguanine

4 entries

0.02

5,6-dihydrouracil-DNA

Homo sapiens

NEIL1

707458

0.00037 - 0.00092

8-oxo-7,8-dihydroguanine:Cyt oligodeoxynucleotide

9 entries

0.05 - 0.0883

DNA

3 entries

0.004 - 0.015

DNA containing 5,6-dihydrouracil

6 entries

0.00078 - 0.053

DNA containing 7-deaza-2'-deoxyguanosine

2 entries

0.000383 - 0.025

DNA containing 7-hydro-8-oxoguanine residues

3 entries

0.00025 - 0.00051

DNA containing 7-methyl-8-oxo-2'-deoxyguanosine

2 entries

0.000167 - 0.03

DNA containing 8-hydroxyguanine residues

3 entries

0.00167

DNA containing 8-hyroxyguanine

Escherichia coli

pH 7.8, 37°C, 34-oligomer, K57R mutant Fpg

646950

0.043 - 0.066

DNA containing 8-oxo-2'-deoxyguanosine

2 entries

0.0003 - 0.0067

DNA containing 8-oxo-guanine residues

6 entries

0.000075 - 0.00011

DNA containing 8-oxo-guanine residues mispaired to adenine

2 entries

0.00038 - 0.0035

DNA containing 8-oxo-guanine residues mispaired to guanine

2 entries

0.0003 - 0.0047

DNA containing 8-oxo-guanine residues mispaired to thymine

2 entries

0.00045

DNA containing 8-thio-2'-deoxyguanosine

2 entries

0.0012 - 0.085

DNA containing ring-opened N7-methylguanine residues

5 entries

additional information

Escherichia coli

turnover of duplex oligonucleotides and mismatched duplexes

646933