Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P05523 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
DNA containing ring-opened N7-methylguanine + H2O = deguanylated DNA + 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine | the damaged base is first destabilized by the enzyme binding and then everted from DNA, followed by insertion of several amino acid residues into DNA and isomerization of the enzyme into a pre-excision complex | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA containing 8-oxoguanine opposite A + H2O | poor substrate, analysis of rate constants of conformational transitions | Escherichia coli | 8-oxoguanine + DNA | - |
? | |
DNA containing 8-oxoguanine opposite C + H2O | good substrate, analysis of rate constants of conformational transitions | Escherichia coli | 8-oxoguanine + DNA | - |
? | |
DNA containing 8-oxoguanine opposite G + H2O | analysis of rate constants of conformational transitions | Escherichia coli | 8-oxoguanine + DNA | - |
? | |
DNA containing 8-oxoguanine opposite T + H2O | analysis of rate constants of conformational transitions | Escherichia coli | 8-oxoguanine + DNA | - |
? | |
DNA containing dihydrouracil + H2O | - |
Escherichia coli | 8-oxoguanine + DNA | - |
? |