3.2.2.23: DNA-formamidopyrimidine glycosylase

This is an abbreviated version!
For detailed information about DNA-formamidopyrimidine glycosylase, go to the full flat file.

Word Map on EC 3.2.2.23

3.2.2.23

strand

comet

glycosylases

genotoxic

purine

single-stranded

abasic

duplex

fpg-sensitive

thymine

excises

7,8-dihydro-8-oxoguanine

ape1

ring-opened

8-oxo-7,8-dihydroguanine

8-oxodg

endonucleases

8-oxo-7,8-dihydro-2'-deoxyguanosine

5-hydroxyuracil

micronucleus

transversions

neils

alkali-labile

biomonitoring

3-methyladenine-dna

mispairs

interstrand

lesion-specific

spiroiminodihydantoin

bromate

medicine

2'-deoxyguanosine

klenow

ap-endonuclease

uvrabc

miscoding

base-excision

apurinic

8-oxo-2'-deoxyguanosine

monoadducts

dihydrouracil

enzyme-modified

unhook

mutyh

endoiii

analysis

Reaction

DNA containing ring-opened N7-methylguanine

Synonyms

2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase, 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine-DNA glycosylase, 8-hydroxyguanine endonuclease, 8-oxoguanine DNA glycosylase, 8-oxoguanine-DNA glycosylase, deoxyribonucleate glycosidase, DNA glycohydrolase (releasing 2,6-diamino-4-hydroxy-5-(N-methyl)-formamidopyrimidine), DNA glycosylase, endonuclease VIII-like DNA glycosylase, Fapy DNA glycosylase, Fapy-DNA glycosylase, formamidopyrimidineDNA glycosylase, formamidopyrimidine DNA glycosylase, formamidopyrimidine glycosylase, formamidopyrimidine-DNA glycosyl hydrolase, formamidopyrimidine-DNA glycosylase, formamidopyrimidine-N-glycosylase, FPG, Fpg protein, FPG-1, FPG-2, Fpg-L, glycosidase, deoxyribonucleate formamidopyrimidine, More, Mtb-Fpg1, MutM, MutM1, NEH1, NEH2, Nei, NEIL1, NEIL3, OGG1

ECTree

3 Hydrolases

3.2 Glycosylases

3.2.2 Hydrolysing N-glycosyl compounds

3.2.2.23 DNA-formamidopyrimidine glycosylase

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Results	in table
3	Activating Compound
26701	AA Sequence
13	Application
1	CAS Registry Number
26	Cloned(Commentary)
12	Crystallization (Commentary)
417	Disease/ Diagnostics
23	General Information
5	General Stability
3	IC50 Value
18	Inhibitors
3	Ki Value [mM]
89	KM Value [mM]
7	Localization
22	Metals/Ions
23	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
282	Organism
69	PDB ID
20	pH Optimum
2	pI Value
1	Posttranslational Modification
73	Protein Variants
25	Purification (Commentary)
19	Reaction
1	Reaction Type
107	Reference
37	Source Tissue
11	Specific Activity [micromol/min/mg]
1	Storage Stability
297	Substrates and Products (Substrate)
34	Subunits
104	Synonyms
1	Systematic Name
22	Temperature Optimum [°C]
11	Temperature Stability [°C]
66	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.2.2.23 - DNA-formamidopyrimidine glycosylase

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5-Nitroso-2,4,6-triaminopyrimidine

product inhibition

Al3+

Cd2+

preferentially binds to DNA bases rather than phosphates, the presence of the metal ions causes the enzyme to lose the ability for preferential binding to damaged DNA

Co2+

Cu2+

preferentially binds to DNA bases rather than phosphates, the presence of the metal ions causes the enzyme to lose the ability for preferential binding to damaged DNA

707458

d(pA)10-d(pT)10

Escherichia coli

dublex, nonspecific oligonucleotide

646952

d(pA)16-d(pT)16

Escherichia coli

dublex, nonspecific oligonucleotide

646952

DNA containing 2-deoxyribonolactone residues

Lactococcus lactis

suicide inhibitor for formamidopyrimidine-DNA glycosylase

716392

DNA containing 5-hydroxy-5-methylhydantoin residues

Lactococcus lactis

suicide inhibitor for formamidopyrimidine-DNA glycosylase

Fe2+

Formamidopyrimidine

product inhibition

Ni2+

nonspecific ds 8-23mer oligonucleotide

Escherichia coli

competitive inhibitors

646952

tetrahydrofuran-containing DNA dublex

Zn2+

additional information

2 entries