1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, ketoreductase, KLCR1, KR, LCR, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

Metals Ions

Metals Ions on EC 1.1.1.184 - carbonyl reductase (NADPH)

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ag+
1 mM, 3.2% residual activity
Cu2+
1 mM, 7.2% residual activity
Fe2+
-
14% activation at 1 mM
Fe3+
1 mM, no residual activity
Iron
-
detected in enzyme by atomic absorption spectroscopy
KCl
-
optimal activity is observed in the presence of 500 mM NaCl or KCl
Magnesium
-
detected in enzyme by atomic absorption spectroscopy
Mn2+
-
20% activation at 1 mM
NaCl
-
optimal activity is observed in the presence of 500 mM NaCl or KCl
Ni2+
1 mM, 4.8% residual activity
Pb2+
1 mM, 3.2% residual activity
additional information