Reference on EC 1.1.1.184 - carbonyl reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okita, R.T.; Okita, J.R.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase
CRC Crit. Rev. Biochem.
31
101-126
1996
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Wermuth, B.
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase
J. Biol. Chem.
256
1206-1213
1981
Homo sapiens
Manually annotated by BRENDA team
Nakayama, T.; Hara, A.; Sawada, H.
Purification and characterization of a novel pyrazole-sensitive carbonyl reductase in guinea pig lung
Arch. Biochem. Biophys.
217
564-573
1982
Cavia porcellus
Manually annotated by BRENDA team
Bohren, K.M.; von Wartburg, J.P.; Wermuth, B.
Inactivation of carbonyl reductase from human brain by phenylglyoxal and 2,3-butanedione: a comparison with aldehyde reductase and aldose reductase
Biochim. Biophys. Acta
916
185-192
1987
Homo sapiens
Manually annotated by BRENDA team
Iwata, N.; Inazu, N.; Takeo, S.; Satoh, T.
Carbonyl reductases from rat testis and vas deferens. Purification, properties and localization
Eur. J. Biochem.
193
75-81
1990
Rattus norvegicus
Manually annotated by BRENDA team
Matsuura, K.; Nakayama, T.; Nakagawa, M.; Hara, A.; Sawada, H.
Kinetic mechanism of pulmonary carbonyl reductase
Biochem. J.
252
17-22
1988
Cavia porcellus
Manually annotated by BRENDA team
Bohren, K.M.; von Wartburg, J.P.; Wermuth, B.
Kinetics of carbonyl reductase from human brain
Biochem. J.
244
165-171
1987
Homo sapiens
Manually annotated by BRENDA team
Oritani, H.; Deyashiki, Y.; Nakayama, T.; Hara, A.; Sawada, H.; Matsuura, K.; Bunai, Y.; Ohya, I.
Purification and characterization of pig lung carbonyl reductase
Arch. Biochem. Biophys.
292
539-547
1992
Sus scrofa
Manually annotated by BRENDA team
Naganuma, H.; Kondo, J.I.; Kawahara, Y.
Enantiospecific assay for mammalian carbonyl reductase by liquid chromatography with fluorescence detection
J. Chromatogr.
532
65-74
1990
Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Hara, A.; Oritani, H.; Deyashiki, Y.; Nakayama, T.; Sawada, H.
Activation of carbonyl reductase from pig lung by fatty acids
Arch. Biochem. Biophys.
292
548-554
1992
Sus scrofa
Manually annotated by BRENDA team
Usui, S.; Hara, A.; Nakayama, T.; Sawada, H.
Purification and characterization of two forms of microsomal carbonyl reductase in guinea pig liver
Biochem. J.
223
697-705
1984
Cavia porcellus
Manually annotated by BRENDA team
Nakayama, T.; Yashiro, K.; Inoue, Y.; Matsuura, K.; Ichikawa, H.; Hara, A.; Sawada, H.
Characterization of pulmonary carbonyl reductase of mouse and guinea pig
Biochim. Biophys. Acta
882
220-227
1986
Cavia porcellus, Mus musculus
Manually annotated by BRENDA team
Ghosh, D.; Sawicki, M.; Pletnev, V.; Erman, M.; Ohno, S.; Nakajin, S.; Duax, W.L.
Porcine carbonyl reductase: structural basis for a functional monomer in short chain dehydrogenases/reductases
J. Biol. Chem.
276
18457-18463
2001
Sus scrofa
Manually annotated by BRENDA team
Nakanishi, M.; Matsuura, K.; Kaibe, H.; Tanaka, N.; Nonaka, T.; Mitsui, Y.; Hara, A.
Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid
J. Biol. Chem.
272
2218-2222
1997
Mus musculus
Manually annotated by BRENDA team
Nishinaka, T.; Kinoshita, Y.; Terada, N.; Terada, T.; Mizoguchi, T.; Nishihara, T.
Characterization of multiple forms of carbonyl reductase from chicken liver
Enzyme
46
221-228
1993
Gallus gallus
Manually annotated by BRENDA team
Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.
Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis
Biochim. Biophys. Acta
1116
50-56
1992
Homo sapiens
Manually annotated by BRENDA team
Kataoka, M.; Doi, Y.; Sim, T.S.; Shimizu, S.; Yamada, H.
A novel NADPH-dependent carbonyl reductase of Candida macedoniensis: purification and characterization
Arch. Biochem. Biophys.
294
469-474
1992
Candida macedoniensis
Manually annotated by BRENDA team
Nakanishi, M.; Kakumoto, M.; Matsuura, K.; Deyashiki, Y.; Tanaka, N.; Nonaka, T.; Mitsui, Y.; Hara, A.
Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analyses
J. Biochem.
120
257-263
1996
Mus musculus
Manually annotated by BRENDA team
Imamura, Y.; Migita, T.; Otagiri, M.; Choshi, T.; Hibino, S.
Purification and catalytic properties of a tetrameric carbonyl reductase from rabbit heart
J. Biochem.
125
41-47
1999
Oryctolagus cuniculus
Manually annotated by BRENDA team
Imamura, Y.; Migita, T.; Uriu, Y.; Otagiri, M.; Okawara, T.
Inhibitory effects of flavonoids on rabbit heart carbonyl reductase
J. Biochem.
127
653-658
2000
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kita, K.; Matsuzaki, K.; Hashimoto, T.; Yanase, H.; Kato, N.; Chung, M.C.; Kataoka, M.; Shimizu, S.
Cloning of the aldehyde reductase gene from a red yeast, Sporobolomyces salmonicolor, and characterization of the gene and its product
Appl. Environ. Microbiol.
62
2303-2310
1996
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Peters, J.; Minuth, T.; Kula, M.R.
A novel NADH-dependent carbonyl reductase with an extremely broad substrate range from Candida parapsilosis: purification and characterization
Enzyme Microb. Technol.
15
950-958
1993
Candida parapsilosis
Manually annotated by BRENDA team
Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.; Gabbay, K.H.
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase
J. Mol. Biol.
244
659-664
1994
Homo sapiens
Manually annotated by BRENDA team
Okamoto, Y.; Kitamura, S.; Takeshita, M.; Ohta, S.
Microsomal carbonyl reductase responsible for reduction of 4-phenyl-3-buten-2-one in rats
IUBMB Life
48
543-547
1999
Rattus norvegicus
Manually annotated by BRENDA team
Wada, M.; Kataoka, M.; Kawabata, H.; Yasohara, Y.; Kizaki, N.; Hasegawa, J.; Shimizu, S.
Purification and characterization of NADPH-dependent carbonyl reductase, involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate, from Candida magnoliae
Biosci. Biotechnol. Biochem.
62
280-285
1998
Candida magnoliae
Manually annotated by BRENDA team
Yasohara, Y.; Kizaki, N.; Hasegawa, J.; Wada, M.; Kataoka, M.; Shimizu, S.
Molecular cloning and overexpression of the gene encoding an NADPH-dependent carbonyl reductase from Candida magnoliae, involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate
Biosci. Biotechnol. Biochem.
64
1430-1436
2000
Candida magnoliae
Manually annotated by BRENDA team
Forrest, G.L.; Gonzalez, B.
Carbonyl reductase
Chem. Biol. Interact.
129
21-40
2000
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Schieber, A.; Frank, R.W.; Ghisla, S.
Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase
Eur. J. Biochem.
206
491-502
1992
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Wermuth, B.; Platts, K.L.; Seidel, A.; Oesch, F.
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man
Biochem. Pharmacol.
35
1277-1282
1986
Homo sapiens
Manually annotated by BRENDA team
Tanaka, N.; Nonaka, T.; Nakanishi, M.; Deyashiki, Y.; Hara, A.
Crystallization of mouse lung carbonyl reductase complexed with NADPH and analysis of symmetry of its tetrameric molecule
J. Biochem.
118
871-873
1995
Mus musculus
Manually annotated by BRENDA team
Wermuth, B.; Mader-Heinemann, G.; Ernst, E.
Cloning and expression of carbonyl reductase from rat testis
Eur. J. Biochem.
228
473-479
1995
Rattus norvegicus
Manually annotated by BRENDA team
Teartasin, W.; Limpkin, C.; Glod, F.; Spencer, J.; Cox, R.J.; Simpson, T.J.; Crosby, J.; Crump, M.P.; Hadfield, A.T.
Expression, purification and preliminary x-ray diffraction analysis of a ketoreductase from a type II polyketide synthase
Acta Crystallogr. Sect. D
D60
1137-1138
2004
Streptomyces coelicolor
Manually annotated by BRENDA team
Doorn, J.A.; Maser, E.; Blum, A.; Claffey, D.J.; Petersen, D.R.
Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal
Biochemistry
43
13106-13114
2004
Homo sapiens
Manually annotated by BRENDA team
Yamamoto, H.; Kimoto, N.; Matsuyama, A.; Kobayashi, Y.
Purification and properties of a carbonyl reductase useful for production of ethyl (S)-4-chloro-3-hydroxybutanoate from Kluyveromyces lactis
Biosci. Biotechnol. Biochem.
66
1775-1778
2002
Kluyveromyces lactis
Manually annotated by BRENDA team
Saratani, Y.; Uheda, E.; Yamamoto, H.; Nishimura, A.; Yoshizako, F.
Purification and properties of a carbonyl reductase involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate from Cylindrocarpon sclerotigenum IFO 31855
Biosci. Biotechnol. Biochem.
67
1417-1420
2003
Cylindrocarpon sclerotigenum
Manually annotated by BRENDA team
Kizaki, N.; Sawa, I.; Yano, M.; Yasohara, Y.; Hasegawa, J.
Purification and characterization of a yeast carbonyl reductase for synthesis of optically active (R)-styrene oxide derivatives
Biosci. Biotechnol. Biochem.
69
79-86
2005
Rhodotorula glutinis
Manually annotated by BRENDA team
Cha, J.H.; Pae, A.N.; Choi, K.I.; Cho, Y.S.; Kim, W.H.; Han, Y.S.; Yun, H.C.; Lee, J.; Koh, H.Y.; Lee, E.
Stereochemical control in diastereoselective reduction of alpha-substituted-beta-ketoesters using a reductase purified from Kluyveromyces marxianus
Biotechnol. Lett.
24
1695-1698
2002
Kluyveromyces marxianus
-
Manually annotated by BRENDA team
Usami, N.; Ishikura, S.; Abe, H.; Nagano, M.; Uebuchi, M.; Kuniyasu, A.; Otagiri, M.; Nakayama, H.; Imamura, Y.; Hara, A.
Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase
Chem. Biol. Interact.
143-144
353-361
2003
Sus scrofa
Manually annotated by BRENDA team
Terada, T.; Sugihara, Y.; Nakamura, K.; Mizobuchi, H.; Maeda, M.
Further characterization of chinese hamster carbonyl reductases (CHCRs)
Chem. Biol. Interact.
143-144
373-381
2003
Cricetulus griseus
Manually annotated by BRENDA team
Imamura, Y.; Koga, T.; Shimada, H.; Otagiri, M.
Inactivation of rabbit liver carbonyl reductase by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium
J. Enzyme Inhib. Med. Chem.
18
35-39
2003
Oryctolagus cuniculus
Manually annotated by BRENDA team
Sgraja, T.; Ulschmid, J.; Becker, K.; Schneuwly, S.; Klebe, G.; Reuter, K.; Heine, A.
Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster
J. Mol. Biol.
342
1613-1624
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Shimada, H.; Fujiki, S.; Oginuma, M.; Asakawa, M.; Okawara, T.; Kato, K.; Yamamura, S.; Akita, H.; Hara, A.; Imamura, Y.
Stereoselective reduction of 4-benzoylpyridine by recombinant pig heart carbonyl reductase
J. Mol. Catal. B
23
29-35
2003
Sus scrofa
-
Manually annotated by BRENDA team
Aoki, K.; Tanaka, N.; Ishikura, S.; Araki, N.; Imamura, Y.; Hara, A.; Nakamura, K.T.
Crystallization and preliminary X-ray crystallographic studies of pig heart carbonyl reductase
Acta Crystallogr. Sect. F
62
1037-1040
2006
Sus scrofa
Manually annotated by BRENDA team
Maser, E.
Neuroprotective role for carbonyl reductase?
Biochem. Biophys. Res. Commun.
340
1019-1022
2006
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Imamura, Y.; Shimada, H.
Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase
Biol. Pharm. Bull.
28
185-187
2005
Rattus norvegicus
Manually annotated by BRENDA team
Morikawa, S.; Nakai, T.; Yasohara, Y.; Nanba, H.; Kizaki, N.; Hasegawa, J.
Highly active mutants of carbonyl reductase S1 with inverted coenzyme specificity and production of optically active alcohols
Biosci. Biotechnol. Biochem.
69
544-552
2005
Candida magnoliae, Candida magnoliae AKU4643
Manually annotated by BRENDA team
Takenaka, K.; Ogawa, E.; Oyanagi, H.; Wada, H.; Tanaka, F.
Carbonyl reductase expression and its clinical significance in non-small-cell lung cancer
Cancer Epidemiol. Biomarkers Prev.
14
1972-1975
2005
Homo sapiens
Manually annotated by BRENDA team
Slupe, A.; Williams, B.; Larson, C.; Lee, L.M.; Primbs, T.; Bruesch, A.J.; Bjorklund, C.; Warner, D.L.; Peloquin, J.; Shadle, S.E.; Gambliel, H.A.; Cusack, B.J.; Olson, R.D.; Charlier, H.A.
Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase
Cardiovasc. Toxicol.
5
365-376
2005
Homo sapiens (P16152)
Manually annotated by BRENDA team
Oginuma, M.; Shimada, H.; Imamura, Y.
Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart
Chem. Biol. Interact.
155
148-154
2005
Sus scrofa
Manually annotated by BRENDA team
Lakhman, S.S.; Ghosh, D.; Blanco, J.G.
Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)
Drug Metab. Dispos.
33
254-257
2005
Homo sapiens
Manually annotated by BRENDA team
Kamitori, S.; Iguchi, A.; Ohtaki, A.; Yamada, M.; Kita, K.
X-ray structures of NADPH-dependent carbonyl reductase from Sporobolomyces salmonicolor provide insights into stereoselective reductions of carbonyl compounds
J. Mol. Biol.
352
551-558
2005
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Hua, L.
Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity
J. Org. Chem.
71
4202-4205
2006
Candida magnoliae (Q9C4B3)
Manually annotated by BRENDA team
Zhu, D.; Hua, L.
Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase
J. Org. Chem.
71
9484-9486
2006
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Maser, E.; Wsol, V.; Martin, H.J.
11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics
Mol. Cell. Endocrinol.
248
34-37
2006
Homo sapiens
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Buynak, J.D.; Hua, L.
Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies
Org. Biomol. Chem.
4
2690-2695
2006
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Ema, T.; Yagasaki, H.; Okita, N.; Takeda, M.; Sakai, T.
Asymmetric reduction of ketones using recombinant E. coli cells that produce a versatile carbonyl reductase with high enantioselectivity and broad substrate specificity
Tetrahedron
62
6143-6149
2006
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Sun, Y.; Nie, Y.; Mu, X.; Li, X.; Zhang, X.C.; Rao, Z.
Crystallization and preliminary X-ray crystallographic analysis of a carbonyl reductase from Candida parapsilosis
Acta Crystallogr. Sect. F
64
252-254
2008
Candida parapsilosis (B2KJ46)
Manually annotated by BRENDA team
Endo, S.; Matsunaga, T.; Nagano, M.; Abe, H.; Ishikura, S.; Imamura, Y.; Hara, A.
Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase
Biol. Pharm. Bull.
30
1787-1791
2007
Canis lupus familiaris
Manually annotated by BRENDA team
Bhattacharyya, M.S.; Singh, A.; Banerjee, U.C.
Production of carbonyl reductase by Geotrichum candidum in a laboratory scale bioreactor
Biores. Technol.
99
8765-8770
2008
Geotrichum candidum, Geotrichum candidum NCIM
Manually annotated by BRENDA team
Carlquist, M.; Frejd, T.; Gorwa-Grauslund, M.F.
Flavonoids as inhibitors of human carbonyl reductase 1
Chem. Biol. Interact.
174
98-108
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.; Blanco, J.G.
A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity
Drug Metab. Dispos.
35
973-980
2007
Homo sapiens
Manually annotated by BRENDA team
Hoffmann, F.; Sotriffer, C.; Evers, A.; Xiong, G.; Maser, E.
Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein
J. Biotechnol.
129
131-139
2007
Comamonas testosteroni
Manually annotated by BRENDA team
Imamura, Y.; Narumi, R.; Shimada, H.
Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones
J. Enzyme Inhib. Med. Chem.
22
105-109
2007
Sus scrofa
Manually annotated by BRENDA team
Soni, P.; Kansal, H.; Banerjee, U.C.
Optimization of process parameters for the production of carbonyl reductase by Candida viswanathii in a laboratory-scale fermentor
J. Ind. Microbiol. Biotechnol.
35
167-173
2008
Candida viswanathii
Manually annotated by BRENDA team
Miura, T.; Nishinaka, T.; Terada, T.
Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1
Mol. Cell. Biochem.
315
113-121
2008
Homo sapiens, Homo sapiens (O75828)
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Majkowicz, S.; Pan, T.H.; Kantardjieff, K.; Hua, L.
Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation
Org. Lett.
10
525-528
2008
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Zhu, D.; Ankati, H.; Mukherjee, C.; Yang, Y.; Biehl, E.R.; Hua, L.
Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids
Org. Lett.
9
2561-2563
2007
Candida magnoliae
Manually annotated by BRENDA team
Tanaka, N.; Aoki, K.; Ishikura, S.; Nagano, M.; Imamura, Y.; Hara, A.; Nakamura, K.T.
Molecular basis for peroxisomal localization of tetrameric carbonyl reductase
Structure
16
388-397
2008
Sus scrofa (Q8WNV7)
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Geng, Y.; Wang, S.; Sun, Y.; Xiao, R.
Improved production of (R)-1-phenyl-1,2-ethanediol by a codon-optimized R-specific carbonyl reductase from Candida parapsilosis in Escherichia coli
Appl. Biochem. Biotechnol.
160
868-878
2009
Candida parapsilosis (A1X808), Candida parapsilosis, Candida parapsilosis CCTCC M203011 (A1X808)
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Sun, Y.; Zhang, W.; Xiao, R.
Ser67Asp and His68Asp substitutions in candida parapsilosis carbonyl reductase alter the coenzyme specificity and enantioselectivity of ketone reduction
Appl. Environ. Microbiol.
75
2176-2183
2009
Candida parapsilosis (B2KJ46), Candida parapsilosis, Candida parapsilosis CCTCC M203011 (B2KJ46)
Manually annotated by BRENDA team
Kansal, H.; Banerjee, U.C.
Enhancing the biocatalytic potential of carbonyl reductase of Candida viswanathii using aqueous-organic solvent system
Biores. Technol.
100
1041-1047
2009
Candida viswanathii, Candida viswanathii MTCC 5158
Manually annotated by BRENDA team
Ye, Q.; Yan, M.; Xu, L.; Cao, H.; Li, Z.; Chen, Y.; Li, S.; Ying, H.
A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate
Biotechnol. Lett.
31
537-542
2009
Scheffersomyces stipitis (A3GF07), Scheffersomyces stipitis
Manually annotated by BRENDA team
Miura, T.; Nishinaka, T.; Takama, M.; Murakami, M.; Terada, T.
Chinese hamster monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily
Chem. Biol. Interact.
178
110-116
2009
Cricetulus griseus, Cricetulus griseus (Q924V2), Cricetulus griseus (Q924V3), Cricetulus griseus (Q9JJN7)
Manually annotated by BRENDA team
Miura, T.; Itoh, Y.; Takada, M.; Tsutsui, H.; Yukimura, T.; Nishinaka, T.; Terada, T.
Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 3
Chem. Biol. Interact.
178
211-214
2009
Cricetulus griseus, Homo sapiens, Rattus norvegicus (B2GV72)
Manually annotated by BRENDA team
El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann, U.; Martin, H.J.; Maser, E.
Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis
Chem. Biol. Interact.
178
234-241
2009
Homo sapiens (O75828), Homo sapiens (P16152)
Manually annotated by BRENDA team
Kassner, N.; Huse, K.; Martin, H.J.; Goedtel-Armbrust, U.; Metzger, A.; Meineke, I.; Brockmoeller, J.; Klein, K.; Zanger, U.M.; Maser, E.; Wojnowski, L.
Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver
Drug Metab. Dispos.
36
2113-2120
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs, K.W.
Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin
Drug Metab. Dispos.
37
1107-1114
2009
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Zhang, J.; Kalabus, J.L.; Relling, M.V.; Blanco, J.G.
Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors
Drug Metab. Dispos.
37
400-407
2009
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Kalabus, J.L.; Blanco, J.G.
Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER)
Pharm. Res.
25
1730-1734
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Zhang, R.; Zhu, G.; Zhang, W.; Cao, S.; Ou, X.; Li, X.; Bartlam, M.; Xu, Y.; Zhang, X.C.; Rao, Z.
Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity
Protein Sci.
17
1412-1423
2008
Candida parapsilosis (B2KJ46), Candida parapsilosis, Candida parapsilosis CCTCC M203011 (B2KJ46)
Manually annotated by BRENDA team
Zimmermann, T.; Niesen, F.; Pilka, E.; Knapp, S.; Oppermann, U.; Maier, M.
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone
Bioorg. Med. Chem.
17
530-536
2009
Homo sapiens
Manually annotated by BRENDA team
Ye, Q.; Yan, M.; Yao, Z.; Xu, L.; Cao, H.; Li, Z.; Chen, Y.; Li, S.; Bai, J.; Xiong, J.; Ying, H.; Ouyang, P.
A new member of the short-chain dehydrogenases/reductases superfamily: purification, characterization and substrate specificity of a recombinant carbonyl reductase from Pichia stipitis
Biores. Technol.
100
6022-6027
2009
Scheffersomyces stipitis (A3GF07)
Manually annotated by BRENDA team
Suwa, Y.; Ohtsuka, J.; Miyakawa, T.; Imai, F.L.; Okai, M.; Sawano, Y.; Yasohara, Y.; Kataoka, M.; Shimizu, S.; Tanokura, M.
Expression, purification, crystallization and preliminary X-ray analysis of carbonyl reductase S1 from Candida magnoliae
Acta Crystallogr. Sect. F
68
540-542
2012
Candida magnoliae, Candida magnoliae (Q9C4B3), Candida magnoliae AKU4643 (Q9C4B3)
Manually annotated by BRENDA team
Ma, Y.H.; Lv, D.Q.; Zhou, S.; Lai, D.Y.; Chen, Z.M.
Characterization of an aldo-keto reductase from Thermotoga maritima with high thermostability and a broad substrate spectrum
Biotechnol. Lett.
35
757-762
2013
Thermotoga maritima (Q9X265), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X265)
Manually annotated by BRENDA team
Richter, N.; Hummel, W.
Biochemical characterisation of a NADPH-dependent carbonyl reductase from Neurospora crassa reducing alpha- and beta-keto esters
Enzyme Microb. Technol.
48
472-479
2011
Neurospora crassa, Neurospora crassa (Q7S3U4), Neurospora crassa DSM 894 (Q7S3U4)
Manually annotated by BRENDA team
Schweiger, P.; Gross, H.; Deppenmeier, U.
Characterization of two aldo-keto reductases from Gluconobacter oxydans 621H capable of regio- and stereoselective alpha-ketocarbonyl reduction
Appl. Microbiol. Biotechnol.
87
1415-1426
2010
Gluconobacter oxydans (Q5FQJ0), Gluconobacter oxydans (Q5FT75), Gluconobacter oxydans 621H, Gluconobacter oxydans 621H (Q5FQJ0), Gluconobacter oxydans 621H (Q5FT75)
Manually annotated by BRENDA team
Ni, Y.; Li, C.X.; Ma, H.M.; Zhang, J.; Xu, J.H.
Biocatalytic properties of a recombinant aldo-keto reductase with broad substrate spectrum and excellent stereoselectivity
Appl. Microbiol. Biotechnol.
89
1111-1118
2011
Bacillus sp. (E3W861), Bacillus sp. ECU0013 (E3W861)
Manually annotated by BRENDA team
Gao, C.; Zhang, L.; Xie, Y.; Hu, C.; Zhang, Y.; Li, L.; Wang, Y.; Ma, C.; Xu, P.
Production of (3S)-acetoin from diacetyl by using stereoselective NADPH-dependent carbonyl reductase and glucose dehydrogenase
Biores. Technol.
137
111-115
2013
Gluconobacter oxydans (Q5FT75), Gluconobacter oxydans DSM 2003, Gluconobacter oxydans DSM 2003 (Q5FT75)
Manually annotated by BRENDA team
Staab, C.A.; Hartmanova, T.; El-Hawari, Y.; Ebert, B.; Kisiela, M.; Wsol, V.; Martin, H.J.; Maser, E.
Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3
Chem. Biol. Interact.
191
95-103
2011
Homo sapiens (O75828), Homo sapiens (P16152)
Manually annotated by BRENDA team
Hartmanova, T.; Tambor, V.; Len?o, J.; Staab-Weijnitz, C.A.; Maser, E.; Wsol, V.
S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity
Chem. Biol. Interact.
202
136-145
2013
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Tang, X.; Mu, P.; Wu, J.; Jiang, J.; Zhang, C.; Zheng, M.; Deng, Y.
Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned carbonyl reductase 1
Drug Metab. Dispos.
40
788-795
2012
Gallus gallus (F1N8Y3), Gallus gallus, Sus scrofa (Q28960), Sus scrofa
Manually annotated by BRENDA team
Bleicher, K.; Winter, J.
Purification and properties of F420- and NADP(+)-dependent alcohol dehydrogenases of Methanogenium liminatans and Methanobacterium palustre, specific for secondary alcohols
Eur. J. Biochem.
200
43-51
1991
Methanobacterium palustre, Methanobacterium palustre DSM 3108
Manually annotated by BRENDA team
Li, N.; Ni, Y.; Sun, Z.
Purification and characterization of carbonyl reductase from Candida krusei SW 2026 involved in enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate
J. Mol. Catal. B
66
190-197
2010
Pichia kudriavzevii, Pichia kudriavzevii SW 2026
-
Manually annotated by BRENDA team
Li, Z.; Liu, W.; Chen, X.; Jia, S.; Wu, Q.; Zhu, D.; Ma, Y.
Highly enantioselective double reduction of phenylglyoxal to (R)-1-phenyl-1,2-ethanediol by one NADPH-dependent yeast carbonyl reductase with a broad substrate profile
Tetrahedron
69
3561-3564
2013
Komagataella pastoris, Komagataella pastoris GS115
-
Manually annotated by BRENDA team
Molnari, J.; Myers, A.
Carbonyl reduction of bupropion in human liver
Xenobiotica
42
550-561
2012
Homo sapiens
Manually annotated by BRENDA team
Hou, H.; Li, R.; Wang, X.; Yuan, Z.; Liu, X.; Chen, Z.; Xu, X.
Crystallographic analysis of a novel aldo-keto reductase from Thermotoga maritima in complex with NADP+
Acta Crystallogr. Sect. F
71
847-855
2015
Thermotoga maritima (Q9X265), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X265)
Manually annotated by BRENDA team