Reference on EC 1.1.1.184 - carbonyl reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okita, R.T.; Okita, J.R.
Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD+-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase
CRC Crit. Rev. Biochem.
31
101-126
1996
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Wermuth, B.
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase
J. Biol. Chem.
256
1206-1213
1981
Homo sapiens
Manually annotated by BRENDA team
Nakayama, T.; Hara, A.; Sawada, H.
Purification and characterization of a novel pyrazole-sensitive carbonyl reductase in guinea pig lung
Arch. Biochem. Biophys.
217
564-573
1982
Cavia porcellus
Manually annotated by BRENDA team
Bohren, K.M.; von Wartburg, J.P.; Wermuth, B.
Inactivation of carbonyl reductase from human brain by phenylglyoxal and 2,3-butanedione: a comparison with aldehyde reductase and aldose reductase
Biochim. Biophys. Acta
916
185-192
1987
Homo sapiens
Manually annotated by BRENDA team
Iwata, N.; Inazu, N.; Takeo, S.; Satoh, T.
Carbonyl reductases from rat testis and vas deferens. Purification, properties and localization
Eur. J. Biochem.
193
75-81
1990
Rattus norvegicus
Manually annotated by BRENDA team
Matsuura, K.; Nakayama, T.; Nakagawa, M.; Hara, A.; Sawada, H.
Kinetic mechanism of pulmonary carbonyl reductase
Biochem. J.
252
17-22
1988
Cavia porcellus
Manually annotated by BRENDA team
Bohren, K.M.; von Wartburg, J.P.; Wermuth, B.
Kinetics of carbonyl reductase from human brain
Biochem. J.
244
165-171
1987
Homo sapiens
Manually annotated by BRENDA team
Oritani, H.; Deyashiki, Y.; Nakayama, T.; Hara, A.; Sawada, H.; Matsuura, K.; Bunai, Y.; Ohya, I.
Purification and characterization of pig lung carbonyl reductase
Arch. Biochem. Biophys.
292
539-547
1992
Sus scrofa
Manually annotated by BRENDA team
Naganuma, H.; Kondo, J.I.; Kawahara, Y.
Enantiospecific assay for mammalian carbonyl reductase by liquid chromatography with fluorescence detection
J. Chromatogr.
532
65-74
1990
Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Hara, A.; Oritani, H.; Deyashiki, Y.; Nakayama, T.; Sawada, H.
Activation of carbonyl reductase from pig lung by fatty acids
Arch. Biochem. Biophys.
292
548-554
1992
Sus scrofa
Manually annotated by BRENDA team
Usui, S.; Hara, A.; Nakayama, T.; Sawada, H.
Purification and characterization of two forms of microsomal carbonyl reductase in guinea pig liver
Biochem. J.
223
697-705
1984
Cavia porcellus
Manually annotated by BRENDA team
Nakayama, T.; Yashiro, K.; Inoue, Y.; Matsuura, K.; Ichikawa, H.; Hara, A.; Sawada, H.
Characterization of pulmonary carbonyl reductase of mouse and guinea pig
Biochim. Biophys. Acta
882
220-227
1986
Cavia porcellus, Mus musculus
Manually annotated by BRENDA team
Ghosh, D.; Sawicki, M.; Pletnev, V.; Erman, M.; Ohno, S.; Nakajin, S.; Duax, W.L.
Porcine carbonyl reductase: structural basis for a functional monomer in short chain dehydrogenases/reductases
J. Biol. Chem.
276
18457-18463
2001
Sus scrofa
Manually annotated by BRENDA team
Nakanishi, M.; Matsuura, K.; Kaibe, H.; Tanaka, N.; Nonaka, T.; Mitsui, Y.; Hara, A.
Switch of coenzyme specificity of mouse lung carbonyl reductase by substitution of threonine 38 with aspartic acid
J. Biol. Chem.
272
2218-2222
1997
Mus musculus
Manually annotated by BRENDA team
Nishinaka, T.; Kinoshita, Y.; Terada, N.; Terada, T.; Mizoguchi, T.; Nishihara, T.
Characterization of multiple forms of carbonyl reductase from chicken liver
Enzyme
46
221-228
1993
Gallus gallus
Manually annotated by BRENDA team
Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.
Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis
Biochim. Biophys. Acta
1116
50-56
1992
Homo sapiens
Manually annotated by BRENDA team
Kataoka, M.; Doi, Y.; Sim, T.S.; Shimizu, S.; Yamada, H.
A novel NADPH-dependent carbonyl reductase of Candida macedoniensis: purification and characterization
Arch. Biochem. Biophys.
294
469-474
1992
Candida macedoniensis
Manually annotated by BRENDA team
Nakanishi, M.; Kakumoto, M.; Matsuura, K.; Deyashiki, Y.; Tanaka, N.; Nonaka, T.; Mitsui, Y.; Hara, A.
Involvement of two basic residues (Lys-17 and Arg-39) of mouse lung carbonyl reductase in NADP(H)-binding and fatty acid activation: site-directed mutagenesis and kinetic analyses
J. Biochem.
120
257-263
1996
Mus musculus
Manually annotated by BRENDA team
Imamura, Y.; Migita, T.; Otagiri, M.; Choshi, T.; Hibino, S.
Purification and catalytic properties of a tetrameric carbonyl reductase from rabbit heart
J. Biochem.
125
41-47
1999
Oryctolagus cuniculus
Manually annotated by BRENDA team
Imamura, Y.; Migita, T.; Uriu, Y.; Otagiri, M.; Okawara, T.
Inhibitory effects of flavonoids on rabbit heart carbonyl reductase
J. Biochem.
127
653-658
2000
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kita, K.; Matsuzaki, K.; Hashimoto, T.; Yanase, H.; Kato, N.; Chung, M.C.; Kataoka, M.; Shimizu, S.
Cloning of the aldehyde reductase gene from a red yeast, Sporobolomyces salmonicolor, and characterization of the gene and its product
Appl. Environ. Microbiol.
62
2303-2310
1996
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Peters, J.; Minuth, T.; Kula, M.R.
A novel NADH-dependent carbonyl reductase with an extremely broad substrate range from Candida parapsilosis: purification and characterization
Enzyme Microb. Technol.
15
950-958
1993
Candida parapsilosis
Manually annotated by BRENDA team
Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.; Gabbay, K.H.
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase
J. Mol. Biol.
244
659-664
1994
Homo sapiens
Manually annotated by BRENDA team
Okamoto, Y.; Kitamura, S.; Takeshita, M.; Ohta, S.
Microsomal carbonyl reductase responsible for reduction of 4-phenyl-3-buten-2-one in rats
IUBMB Life
48
543-547
1999
Rattus norvegicus
Manually annotated by BRENDA team
Wada, M.; Kataoka, M.; Kawabata, H.; Yasohara, Y.; Kizaki, N.; Hasegawa, J.; Shimizu, S.
Purification and characterization of NADPH-dependent carbonyl reductase, involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate, from Candida magnoliae
Biosci. Biotechnol. Biochem.
62
280-285
1998
Candida magnoliae
Manually annotated by BRENDA team
Yasohara, Y.; Kizaki, N.; Hasegawa, J.; Wada, M.; Kataoka, M.; Shimizu, S.
Molecular cloning and overexpression of the gene encoding an NADPH-dependent carbonyl reductase from Candida magnoliae, involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate
Biosci. Biotechnol. Biochem.
64
1430-1436
2000
Candida magnoliae
Manually annotated by BRENDA team
Forrest, G.L.; Gonzalez, B.
Carbonyl reductase
Chem. Biol. Interact.
129
21-40
2000
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Schieber, A.; Frank, R.W.; Ghisla, S.
Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase
Eur. J. Biochem.
206
491-502
1992
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Wermuth, B.; Platts, K.L.; Seidel, A.; Oesch, F.
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man
Biochem. Pharmacol.
35
1277-1282
1986
Homo sapiens
Manually annotated by BRENDA team
Tanaka, N.; Nonaka, T.; Nakanishi, M.; Deyashiki, Y.; Hara, A.
Crystallization of mouse lung carbonyl reductase complexed with NADPH and analysis of symmetry of its tetrameric molecule
J. Biochem.
118
871-873
1995
Mus musculus
Manually annotated by BRENDA team
Wermuth, B.; Mader-Heinemann, G.; Ernst, E.
Cloning and expression of carbonyl reductase from rat testis
Eur. J. Biochem.
228
473-479
1995
Rattus norvegicus
Manually annotated by BRENDA team
Teartasin, W.; Limpkin, C.; Glod, F.; Spencer, J.; Cox, R.J.; Simpson, T.J.; Crosby, J.; Crump, M.P.; Hadfield, A.T.
Expression, purification and preliminary x-ray diffraction analysis of a ketoreductase from a type II polyketide synthase
Acta Crystallogr. Sect. D
D60
1137-1138
2004
Streptomyces coelicolor
Manually annotated by BRENDA team
Doorn, J.A.; Maser, E.; Blum, A.; Claffey, D.J.; Petersen, D.R.
Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal
Biochemistry
43
13106-13114
2004
Homo sapiens
Manually annotated by BRENDA team
Yamamoto, H.; Kimoto, N.; Matsuyama, A.; Kobayashi, Y.
Purification and properties of a carbonyl reductase useful for production of ethyl (S)-4-chloro-3-hydroxybutanoate from Kluyveromyces lactis
Biosci. Biotechnol. Biochem.
66
1775-1778
2002
Kluyveromyces lactis
Manually annotated by BRENDA team
Saratani, Y.; Uheda, E.; Yamamoto, H.; Nishimura, A.; Yoshizako, F.
Purification and properties of a carbonyl reductase involved in stereoselective reduction of ethyl 4-chloro-3-oxobutanoate from Cylindrocarpon sclerotigenum IFO 31855
Biosci. Biotechnol. Biochem.
67
1417-1420
2003
Cylindrocarpon sclerotigenum
Manually annotated by BRENDA team
Kizaki, N.; Sawa, I.; Yano, M.; Yasohara, Y.; Hasegawa, J.
Purification and characterization of a yeast carbonyl reductase for synthesis of optically active (R)-styrene oxide derivatives
Biosci. Biotechnol. Biochem.
69
79-86
2005
Rhodotorula glutinis
Manually annotated by BRENDA team
Cha, J.H.; Pae, A.N.; Choi, K.I.; Cho, Y.S.; Kim, W.H.; Han, Y.S.; Yun, H.C.; Lee, J.; Koh, H.Y.; Lee, E.
Stereochemical control in diastereoselective reduction of alpha-substituted-beta-ketoesters using a reductase purified from Kluyveromyces marxianus
Biotechnol. Lett.
24
1695-1698
2002
Kluyveromyces marxianus
-
Manually annotated by BRENDA team
Usami, N.; Ishikura, S.; Abe, H.; Nagano, M.; Uebuchi, M.; Kuniyasu, A.; Otagiri, M.; Nakayama, H.; Imamura, Y.; Hara, A.
Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase
Chem. Biol. Interact.
143-144
353-361
2003
Sus scrofa
Manually annotated by BRENDA team
Terada, T.; Sugihara, Y.; Nakamura, K.; Mizobuchi, H.; Maeda, M.
Further characterization of chinese hamster carbonyl reductases (CHCRs)
Chem. Biol. Interact.
143-144
373-381
2003
Cricetulus griseus
Manually annotated by BRENDA team
Imamura, Y.; Koga, T.; Shimada, H.; Otagiri, M.
Inactivation of rabbit liver carbonyl reductase by phenylglyoxal and 2,3,4-trinitrobenzenesulfonate sodium
J. Enzyme Inhib. Med. Chem.
18
35-39
2003
Oryctolagus cuniculus
Manually annotated by BRENDA team
Sgraja, T.; Ulschmid, J.; Becker, K.; Schneuwly, S.; Klebe, G.; Reuter, K.; Heine, A.
Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster
J. Mol. Biol.
342
1613-1624
2004
Drosophila melanogaster
Manually annotated by BRENDA team
Shimada, H.; Fujiki, S.; Oginuma, M.; Asakawa, M.; Okawara, T.; Kato, K.; Yamamura, S.; Akita, H.; Hara, A.; Imamura, Y.
Stereoselective reduction of 4-benzoylpyridine by recombinant pig heart carbonyl reductase
J. Mol. Catal. B
23
29-35
2003
Sus scrofa
-
Manually annotated by BRENDA team
Aoki, K.; Tanaka, N.; Ishikura, S.; Araki, N.; Imamura, Y.; Hara, A.; Nakamura, K.T.
Crystallization and preliminary X-ray crystallographic studies of pig heart carbonyl reductase
Acta Crystallogr. Sect. F
62
1037-1040
2006
Sus scrofa
Manually annotated by BRENDA team
Maser, E.
Neuroprotective role for carbonyl reductase?
Biochem. Biophys. Res. Commun.
340
1019-1022
2006
Drosophila melanogaster, Homo sapiens
Manually annotated by BRENDA team
Imamura, Y.; Shimada, H.
Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase
Biol. Pharm. Bull.
28
185-187
2005
Rattus norvegicus
Manually annotated by BRENDA team
Morikawa, S.; Nakai, T.; Yasohara, Y.; Nanba, H.; Kizaki, N.; Hasegawa, J.
Highly active mutants of carbonyl reductase S1 with inverted coenzyme specificity and production of optically active alcohols
Biosci. Biotechnol. Biochem.
69
544-552
2005
Candida magnoliae, Candida magnoliae AKU4643
Manually annotated by BRENDA team
Takenaka, K.; Ogawa, E.; Oyanagi, H.; Wada, H.; Tanaka, F.
Carbonyl reductase expression and its clinical significance in non-small-cell lung cancer
Cancer Epidemiol. Biomarkers Prev.
14
1972-1975
2005
Homo sapiens
Manually annotated by BRENDA team
Slupe, A.; Williams, B.; Larson, C.; Lee, L.M.; Primbs, T.; Bruesch, A.J.; Bjorklund, C.; Warner, D.L.; Peloquin, J.; Shadle, S.E.; Gambliel, H.A.; Cusack, B.J.; Olson, R.D.; Charlier, H.A.
Reduction of 13-deoxydoxorubicin and daunorubicinol anthraquinones by human carbonyl reductase
Cardiovasc. Toxicol.
5
365-376
2005
Homo sapiens (P16152)
Manually annotated by BRENDA team
Oginuma, M.; Shimada, H.; Imamura, Y.
Involvement of carbonyl reductase in superoxide formation through redox cycling of adrenochrome and 9,10-phenanthrenequinone in pig heart
Chem. Biol. Interact.
155
148-154
2005
Sus scrofa
Manually annotated by BRENDA team
Lakhman, S.S.; Ghosh, D.; Blanco, J.G.
Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)
Drug Metab. Dispos.
33
254-257
2005
Homo sapiens
Manually annotated by BRENDA team
Kamitori, S.; Iguchi, A.; Ohtaki, A.; Yamada, M.; Kita, K.
X-ray structures of NADPH-dependent carbonyl reductase from Sporobolomyces salmonicolor provide insights into stereoselective reductions of carbonyl compounds
J. Mol. Biol.
352
551-558
2005
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Hua, L.
Stereoselective enzymatic synthesis of chiral alcohols with the use of a carbonyl reductase from Candida magnoliae with anti-Prelog enantioselectivity
J. Org. Chem.
71
4202-4205
2006
Candida magnoliae (Q9C4B3)
Manually annotated by BRENDA team
Zhu, D.; Hua, L.
Enantioselective enzymatic reductions of sterically bulky aryl alkyl ketones catalyzed by a NADPH-dependent carbonyl reductase
J. Org. Chem.
71
9484-9486
2006
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Maser, E.; Wsol, V.; Martin, H.J.
11beta-Hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics
Mol. Cell. Endocrinol.
248
34-37
2006
Homo sapiens
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Buynak, J.D.; Hua, L.
Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies
Org. Biomol. Chem.
4
2690-2695
2006
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Ema, T.; Yagasaki, H.; Okita, N.; Takeda, M.; Sakai, T.
Asymmetric reduction of ketones using recombinant E. coli cells that produce a versatile carbonyl reductase with high enantioselectivity and broad substrate specificity
Tetrahedron
62
6143-6149
2006
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Sun, Y.; Nie, Y.; Mu, X.; Li, X.; Zhang, X.C.; Rao, Z.
Crystallization and preliminary X-ray crystallographic analysis of a carbonyl reductase from Candida parapsilosis
Acta Crystallogr. Sect. F
64
252-254
2008
Candida parapsilosis (B2KJ46)
Manually annotated by BRENDA team
Endo, S.; Matsunaga, T.; Nagano, M.; Abe, H.; Ishikura, S.; Imamura, Y.; Hara, A.
Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase
Biol. Pharm. Bull.
30
1787-1791
2007
Canis lupus familiaris
Manually annotated by BRENDA team
Bhattacharyya, M.S.; Singh, A.; Banerjee, U.C.
Production of carbonyl reductase by Geotrichum candidum in a laboratory scale bioreactor
Biores. Technol.
99
8765-8770
2008
Galactomyces candidum, Galactomyces candidum NCIM 980
Manually annotated by BRENDA team
Carlquist, M.; Frejd, T.; Gorwa-Grauslund, M.F.
Flavonoids as inhibitors of human carbonyl reductase 1
Chem. Biol. Interact.
174
98-108
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.; Blanco, J.G.
A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity
Drug Metab. Dispos.
35
973-980
2007
Homo sapiens
Manually annotated by BRENDA team
Hoffmann, F.; Sotriffer, C.; Evers, A.; Xiong, G.; Maser, E.
Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein
J. Biotechnol.
129
131-139
2007
Comamonas testosteroni
Manually annotated by BRENDA team
Imamura, Y.; Narumi, R.; Shimada, H.
Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones
J. Enzyme Inhib. Med. Chem.
22
105-109
2007
Sus scrofa
Manually annotated by BRENDA team
Soni, P.; Kansal, H.; Banerjee, U.C.
Optimization of process parameters for the production of carbonyl reductase by Candida viswanathii in a laboratory-scale fermentor
J. Ind. Microbiol. Biotechnol.
35
167-173
2008
Candida viswanathii
Manually annotated by BRENDA team
Miura, T.; Nishinaka, T.; Terada, T.
Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1
Mol. Cell. Biochem.
315
113-121
2008
Homo sapiens, Homo sapiens (O75828)
Manually annotated by BRENDA team
Zhu, D.; Yang, Y.; Majkowicz, S.; Pan, T.H.; Kantardjieff, K.; Hua, L.
Inverting the enantioselectivity of a carbonyl reductase via substrate-enzyme docking-guided point mutation
Org. Lett.
10
525-528
2008
Sporidiobolus salmonicolor
Manually annotated by BRENDA team
Zhu, D.; Ankati, H.; Mukherjee, C.; Yang, Y.; Biehl, E.R.; Hua, L.
Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids
Org. Lett.
9
2561-2563
2007
Candida magnoliae
Manually annotated by BRENDA team
Tanaka, N.; Aoki, K.; Ishikura, S.; Nagano, M.; Imamura, Y.; Hara, A.; Nakamura, K.T.
Molecular basis for peroxisomal localization of tetrameric carbonyl reductase
Structure
16
388-397
2008
Sus scrofa (Q8WNV7), Sus scrofa
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Geng, Y.; Wang, S.; Sun, Y.; Xiao, R.
Improved production of (R)-1-phenyl-1,2-ethanediol by a codon-optimized R-specific carbonyl reductase from Candida parapsilosis in Escherichia coli
Appl. Biochem. Biotechnol.
160
868-878
2009
Candida parapsilosis (A1X808), Candida parapsilosis
Manually annotated by BRENDA team
Zhang, R.; Xu, Y.; Sun, Y.; Zhang, W.; Xiao, R.
Ser67Asp and His68Asp substitutions in candida parapsilosis carbonyl reductase alter the coenzyme specificity and enantioselectivity of ketone reduction
Appl. Environ. Microbiol.
75
2176-2183
2009
Candida parapsilosis (B2KJ46), Candida parapsilosis
Manually annotated by BRENDA team
Kansal, H.; Banerjee, U.C.
Enhancing the biocatalytic potential of carbonyl reductase of Candida viswanathii using aqueous-organic solvent system
Biores. Technol.
100
1041-1047
2009
Candida viswanathii, Candida viswanathii MTCC 5158
Manually annotated by BRENDA team
Ye, Q.; Yan, M.; Xu, L.; Cao, H.; Li, Z.; Chen, Y.; Li, S.; Ying, H.
A novel carbonyl reductase from Pichia stipitis for the production of ethyl (S)-4-chloro-3-hydroxybutanoate
Biotechnol. Lett.
31
537-542
2009
Scheffersomyces stipitis (A3GF07), Scheffersomyces stipitis
Manually annotated by BRENDA team
Miura, T.; Nishinaka, T.; Takama, M.; Murakami, M.; Terada, T.
Chinese hamster monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily
Chem. Biol. Interact.
178
110-116
2009
Cricetulus griseus, Cricetulus griseus (Q924V2), Cricetulus griseus (Q924V3), Cricetulus griseus (Q9JJN7)
Manually annotated by BRENDA team
Miura, T.; Itoh, Y.; Takada, M.; Tsutsui, H.; Yukimura, T.; Nishinaka, T.; Terada, T.
Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 3
Chem. Biol. Interact.
178
211-214
2009
Cricetulus griseus, Homo sapiens, Rattus norvegicus (B2GV72)
Manually annotated by BRENDA team
El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann, U.; Martin, H.J.; Maser, E.
Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis
Chem. Biol. Interact.
178
234-241
2009
Homo sapiens (O75828), Homo sapiens (P16152)
Manually annotated by BRENDA team
Kassner, N.; Huse, K.; Martin, H.J.; Goedtel-Armbrust, U.; Metzger, A.; Meineke, I.; Brockmoeller, J.; Klein, K.; Zanger, U.M.; Maser, E.; Wojnowski, L.
Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver
Drug Metab. Dispos.
36
2113-2120
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs, K.W.
Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin
Drug Metab. Dispos.
37
1107-1114
2009
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Zhang, J.; Kalabus, J.L.; Relling, M.V.; Blanco, J.G.
Pharmacogenetics of human carbonyl reductase 1 (CBR1) in livers from black and white donors
Drug Metab. Dispos.
37
400-407
2009
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Gonzalez-Covarrubias, V.; Kalabus, J.L.; Blanco, J.G.
Inhibition of polymorphic human carbonyl reductase 1 (CBR1) by the cardioprotectant flavonoid 7-monohydroxyethyl rutoside (monoHER)
Pharm. Res.
25
1730-1734
2008
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Zhang, R.; Zhu, G.; Zhang, W.; Cao, S.; Ou, X.; Li, X.; Bartlam, M.; Xu, Y.; Zhang, X.C.; Rao, Z.
Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity
Protein Sci.
17
1412-1423
2008
Candida parapsilosis (B2KJ46), Candida parapsilosis
Manually annotated by BRENDA team
Zimmermann, T.; Niesen, F.; Pilka, E.; Knapp, S.; Oppermann, U.; Maier, M.
Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone
Bioorg. Med. Chem.
17
530-536
2009
Homo sapiens
Manually annotated by BRENDA team
Ye, Q.; Yan, M.; Yao, Z.; Xu, L.; Cao, H.; Li, Z.; Chen, Y.; Li, S.; Bai, J.; Xiong, J.; Ying, H.; Ouyang, P.
A new member of the short-chain dehydrogenases/reductases superfamily: purification, characterization and substrate specificity of a recombinant carbonyl reductase from Pichia stipitis
Biores. Technol.
100
6022-6027
2009
Scheffersomyces stipitis (A3GF07)
Manually annotated by BRENDA team
Suwa, Y.; Ohtsuka, J.; Miyakawa, T.; Imai, F.L.; Okai, M.; Sawano, Y.; Yasohara, Y.; Kataoka, M.; Shimizu, S.; Tanokura, M.
Expression, purification, crystallization and preliminary X-ray analysis of carbonyl reductase S1 from Candida magnoliae
Acta Crystallogr. Sect. F
68
540-542
2012
Candida magnoliae, Candida magnoliae (Q9C4B3), Candida magnoliae AKU4643 (Q9C4B3)
Manually annotated by BRENDA team
Ma, Y.H.; Lv, D.Q.; Zhou, S.; Lai, D.Y.; Chen, Z.M.
Characterization of an aldo-keto reductase from Thermotoga maritima with high thermostability and a broad substrate spectrum
Biotechnol. Lett.
35
757-762
2013
Thermotoga maritima (Q9X265), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X265), Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (Q9X265)
Manually annotated by BRENDA team
Richter, N.; Hummel, W.
Biochemical characterisation of a NADPH-dependent carbonyl reductase from Neurospora crassa reducing alpha- and beta-keto esters
Enzyme Microb. Technol.
48
472-479
2011
Neurospora crassa, Neurospora crassa (Q7S3U4), Neurospora crassa DSM 894 (Q7S3U4)
Manually annotated by BRENDA team
Schweiger, P.; Gross, H.; Deppenmeier, U.
Characterization of two aldo-keto reductases from Gluconobacter oxydans 621H capable of regio- and stereoselective alpha-ketocarbonyl reduction
Appl. Microbiol. Biotechnol.
87
1415-1426
2010
Gluconobacter oxydans (Q5FQJ0), Gluconobacter oxydans (Q5FT75), Gluconobacter oxydans 621H, Gluconobacter oxydans 621H (Q5FQJ0), Gluconobacter oxydans 621H (Q5FT75)
Manually annotated by BRENDA team
Ni, Y.; Li, C.X.; Ma, H.M.; Zhang, J.; Xu, J.H.
Biocatalytic properties of a recombinant aldo-keto reductase with broad substrate spectrum and excellent stereoselectivity
Appl. Microbiol. Biotechnol.
89
1111-1118
2011
Bacillus sp. (in: Bacteria) (E3W861), Bacillus sp. (in: Bacteria) ECU0013 (E3W861)
Manually annotated by BRENDA team
Gao, C.; Zhang, L.; Xie, Y.; Hu, C.; Zhang, Y.; Li, L.; Wang, Y.; Ma, C.; Xu, P.
Production of (3S)-acetoin from diacetyl by using stereoselective NADPH-dependent carbonyl reductase and glucose dehydrogenase
Biores. Technol.
137
111-115
2013
Gluconobacter oxydans, Gluconobacter oxydans DSM 2003
Manually annotated by BRENDA team
Staab, C.A.; Hartmanova, T.; El-Hawari, Y.; Ebert, B.; Kisiela, M.; Wsol, V.; Martin, H.J.; Maser, E.
Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3
Chem. Biol. Interact.
191
95-103
2011
Homo sapiens (O75828), Homo sapiens (P16152)
Manually annotated by BRENDA team
Hartmanova, T.; Tambor, V.; Len?o, J.; Staab-Weijnitz, C.A.; Maser, E.; Wsol, V.
S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity
Chem. Biol. Interact.
202
136-145
2013
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Tang, X.; Mu, P.; Wu, J.; Jiang, J.; Zhang, C.; Zheng, M.; Deng, Y.
Carbonyl reduction of mequindox by chicken and porcine cytosol and cloned carbonyl reductase 1
Drug Metab. Dispos.
40
788-795
2012
Gallus gallus (F1N8Y3), Gallus gallus, Sus scrofa (Q28960), Sus scrofa
Manually annotated by BRENDA team
Bleicher, K.; Winter, J.
Purification and properties of F420- and NADP(+)-dependent alcohol dehydrogenases of Methanogenium liminatans and Methanobacterium palustre, specific for secondary alcohols
Eur. J. Biochem.
200
43-51
1991
Methanobacterium palustre, Methanobacterium palustre DSM 3108
Manually annotated by BRENDA team
Li, N.; Ni, Y.; Sun, Z.
Purification and characterization of carbonyl reductase from Candida krusei SW 2026 involved in enantioselective reduction of ethyl 2-oxo-4-phenylbutyrate
J. Mol. Catal. B
66
190-197
2010
Pichia kudriavzevii, Pichia kudriavzevii SW 2026
-
Manually annotated by BRENDA team
Li, Z.; Liu, W.; Chen, X.; Jia, S.; Wu, Q.; Zhu, D.; Ma, Y.
Highly enantioselective double reduction of phenylglyoxal to (R)-1-phenyl-1,2-ethanediol by one NADPH-dependent yeast carbonyl reductase with a broad substrate profile
Tetrahedron
69
3561-3564
2013
Komagataella pastoris, Komagataella pastoris GS115
-
Manually annotated by BRENDA team
Molnari, J.; Myers, A.
Carbonyl reduction of bupropion in human liver
Xenobiotica
42
550-561
2012
Homo sapiens
Manually annotated by BRENDA team
Hou, H.; Li, R.; Wang, X.; Yuan, Z.; Liu, X.; Chen, Z.; Xu, X.
Crystallographic analysis of a novel aldo-keto reductase from Thermotoga maritima in complex with NADP+
Acta Crystallogr. Sect. F
71
847-855
2015
Thermotoga maritima (Q9X265), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9X265)
Manually annotated by BRENDA team
Ferguson, D.C.; Cheng, Q.; Blanco, J.G.
Characterization of the canine snthracycline-metabolizing enzyme carbonyl reductase 1 (cbr1) and the functional isoform cbr1 V218
Drug Metab. Dispos.
43
922-927
2015
Canis lupus familiaris, Canis lupus familiaris (J9P7P2)
Manually annotated by BRENDA team
Fukuda, Y.; Sakuraba, H.; Araki, T.; Ohshima, T.; Yoneda, K.
Catalytic properties and crystal structure of thermostable NAD(P)H-dependent carbonyl reductase from the hyperthermophilic archaeon Aeropyrum pernix K1
Enzyme Microb. Technol.
91
17-25
2016
Aeropyrum pernix (Q9Y8Y1)
Manually annotated by BRENDA team
Fukuda, Y.; Sone, T.; Sakuraba, H.; Araki, T.; Ohshima, T.; Shibata, T.; Yoneda, K.
A novel NAD(P)H-dependent carbonyl reductase specifically expressed in the thyroidectomized chicken fatty liver: catalytic properties and crystal structure
FEBS J.
282
3918-3928
2015
Gallus gallus (F1N9C1)
Manually annotated by BRENDA team
Akita, H.; Watanabe, M.; Suzuki, T.; Nakashima, N.; Hoshino, T.
Molecular cloning and characterization of two YGL039w genes encoding broad specificity NADPH-dependent aldehyde reductases from Kluyveromyces marxianus strain DMB1
FEMS Microbiol. Lett.
362
FEHLT
2015
Kluyveromyces marxianus (A0A0E4AX59), Kluyveromyces marxianus (A0A0E4AY21), Kluyveromyces marxianus, Kluyveromyces marxianus DMB1 (A0A0E4AX59), Kluyveromyces marxianus DMB1 (A0A0E4AY21)
Manually annotated by BRENDA team
Moschini, R.; Peroni, E.; Rotondo, R.; Renzone, G.; Melck, D.; Cappiello, M.; Srebot, M.; Napolitano, E.; Motta, A.; Scaloni, A.; Mura, U.; Del-Corso, A.
NADP(+)-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification
Free Radic. Biol. Med.
83
66-76
2015
Homo sapiens
Manually annotated by BRENDA team
Rotondo, R.; Moschini, R.; Renzone, G.; Tuccinardi, T.; Balestri, F.; Cappiello, M.; Scaloni, A.; Mura, U.; Del-Corso, A.
Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation
Free Radic. Biol. Med.
99
323-332
2016
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Lim, S.; Shin, J.Y.; Jo, A.; Jyothi, K.R.; Nguyen, M.N.; Choi, T.G.; Kim, J.; Park, J.H.; Eun, Y.G.; Yoon, K.S.; Ha, J.; Kim, S.S.
Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration
Int. J. Biochem. Cell Biol.
45
1784-1793
2013
Mus musculus (P48758)
Manually annotated by BRENDA team
Shimada, H.; Tanigawa, T.; Matayoshi, K.; Katakura, K.; Babazono, K.; Takayama, H.; Murahashi, T.; Akita, H.; Higuchi, T.; Eto, M.; Imamura, Y.
Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones
J. Enzyme Inhib. Med. Chem.
29
397-400
2014
Sus scrofa
Manually annotated by BRENDA team
Liang, Q.; Liu, R.; Du, S.; Ding, Y.
Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione
J. Struct. Biol.
192
138-144
2015
Homo sapiens, Homo sapiens (P16152)
Manually annotated by BRENDA team
Zhang, R.; Wang, L.; Xu, Y.; Liang, H.; Zhou, X.; Jiang, J.; Li, Y.; Xiao, R.; Ni, Y.
In situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011
Microb. Cell Fact.
15
143
2016
Candida parapsilosis CCTCC M203011 (A1X808)
Manually annotated by BRENDA team
Chen, K.; Li, K.; Deng, J.; Zhang, B.; Lin, J.; Wei, D.
Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol
Microb. Cell Fact.
15
191
2016
Lactobacillus kefiri
Manually annotated by BRENDA team