1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, ketoreductase, KLCR1, KR, LCR, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

KCat KM Value

KCat KM Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
80
(R)-2-butanol
Methanobacterium palustre
-
pH 7.5, 37C
2292
27
(S)-2-butanol
Methanobacterium palustre
-
pH 7.5, 37C
1990
50 - 56.7
1,2-naphthoquinone
1907
8.7 - 73.3
1,4-Naphthoquinone
1083
4 - 5.75
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
19786
25 - 26
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
19787
1.4
2,3-Butanediol
Methanobacterium palustre
-
pH 7.5, 37C
2004
25 - 31.6
2,3-Hexanedione
3302
0.99 - 6.4
2,3-Pentanedione
1963
42
2-butanol
Methanobacterium palustre
-
pH 7.5, 37C
1132
9
2-butanone
Methanobacterium palustre
-
pH 7.5, 37C
1171
1.3
2-Pentanone
Methanobacterium palustre
-
pH 7.5, 37C
1911
81
2-propanol
Methanobacterium palustre
-
pH 7.5, 37C
682
4.8 - 15.7
4-benzoylpyridine
1691
113 - 2828
9,10-phenanthrenequinone
558
11
acetoin
Methanobacterium palustre
-
pH 7.5, 37C
1274
13
cyclohexanone
Methanobacterium palustre
-
pH 7.5, 37C
1299
23
Cyclopentanol
Methanobacterium palustre
-
pH 7.5, 37C
2729
19
Cyclopentanone
Methanobacterium palustre
-
pH 7.5, 37C
2478
203
diacetyl
Methanobacterium palustre
-
pH 7.5, 37C
746
18.3 - 21.7
isatin
805
7.5 - 54.5
menadione
240
11
methylglyoxal
Gluconobacter oxydans
Q5FQJ0
pH 7.0, 25C
322
11600
NADP+
Methanobacterium palustre
-
pH 7.5, 37C
10
5200
NADPH
Methanobacterium palustre
-
pH 7.5, 37C
5
8.2
Phenylglyoxal
Gluconobacter oxydans
Q5FQJ0
pH 7.0, 25C
301
321
propanone
Methanobacterium palustre
-
pH 7.5, 37C
5312
1.72 - 93.45
S-nitrosoglutathione
980