1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

KCat KM Value

KCat KM Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
80
(R)-2-butanol
-
pH 7.5, 37C
27
(S)-2-butanol
-
pH 7.5, 37C
50 - 56.7
1,2-naphthoquinone
8.7 - 73.3
1,4-Naphthoquinone
4 - 5.75
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
25 - 26
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
1.4
2,3-Butanediol
-
pH 7.5, 37C
25 - 31.7
2,3-Hexanedione
0.99 - 6.4
2,3-Pentanedione
42
2-butanol
-
pH 7.5, 37C
9
2-butanone
-
pH 7.5, 37C
1.3
2-Pentanone
-
pH 7.5, 37C
81
2-propanol
-
pH 7.5, 37C
1281
3-glutathionyl-hexanal
-
pH 8.4, 25C
-
4615
3-glutathionyl-nonanal
-
pH 8.4, 25C
-
885
3-glutathionyl-propanal
-
pH 8.4, 25C
-
0.17 - 0.25
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
4.8 - 15.7
4-benzoylpyridine
113 - 2828
9,10-phenanthrenequinone
11
acetoin
-
pH 7.5, 37C
13
cyclohexanone
-
pH 7.5, 37C
23
Cyclopentanol
-
pH 7.5, 37C
19
Cyclopentanone
-
pH 7.5, 37C
11.2 - 18.3
daunorubicin
203
diacetyl
-
pH 7.5, 37C
18.3 - 21.7
isatin
7.5 - 54.5
menadione
11
methylglyoxal
pH 7.0, 25C
11600
NADP+
-
pH 7.5, 37C
5185 - 5200
NADPH
11.3 - 12.2
oracin
8.2
Phenylglyoxal
pH 7.0, 25C
321
propanone
-
pH 7.5, 37C
1.72 - 93.45
S-nitrosoglutathione