1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

KCat KM Value

KCat KM Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
80
(R)-2-butanol
-
pH 7.5, 37°C
27
(S)-2-butanol
-
pH 7.5, 37°C
50 - 56.7
1,2-naphthoquinone
8.7 - 73.3
1,4-Naphthoquinone
4 - 5.75
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
25 - 26
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
1.4
2,3-Butanediol
-
pH 7.5, 37°C
25 - 31.7
2,3-Hexanedione
0.99 - 6.4
2,3-Pentanedione
42
2-butanol
-
pH 7.5, 37°C
9
2-butanone
-
pH 7.5, 37°C
1.3
2-Pentanone
-
pH 7.5, 37°C
81
2-propanol
-
pH 7.5, 37°C
1281
3-glutathionyl-hexanal
-
pH 8.4, 25°C
-
4615
3-glutathionyl-nonanal
-
pH 8.4, 25°C
-
885
3-glutathionyl-propanal
-
pH 8.4, 25°C
-
0.17 - 0.25
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
4.8 - 15.7
4-benzoylpyridine
113 - 2828
9,10-phenanthrenequinone
11
acetoin
-
pH 7.5, 37°C
13
cyclohexanone
-
pH 7.5, 37°C
23
Cyclopentanol
-
pH 7.5, 37°C
19
Cyclopentanone
-
pH 7.5, 37°C
11.2 - 18.3
daunorubicin
203
diacetyl
-
pH 7.5, 37°C
18.3 - 21.7
isatin
7.5 - 54.5
menadione
11
methylglyoxal
pH 7.0, 25°C
11600
NADP+
-
pH 7.5, 37°C
5185 - 5200
NADPH
11.3 - 12.2
oracin
8.2
Phenylglyoxal
pH 7.0, 25°C
321
propanone
-
pH 7.5, 37°C
1.72 - 93.45
S-nitrosoglutathione