1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, ketoreductase, KLCR1, KR, LCR, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

IC50 Value

IC50 Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0042
(2E)-1-(2,4-dihydroxyphenyl)-3-(2',4',6-trihydroxy-5'-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]biphenyl-3-yl)prop-2-en-1-one
Homo sapiens
P16152
pH 7.4, 37°C
0.00021
14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.034 - 0.383
3',4',7-tris[O-(2-hydroxyethyl)]rutin
0.0036
3-(2-(2,4-dihydroxyphenyl)-1-[hydroxy(4-hydroxyphenyl)methyl]-2-oxoethyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Homo sapiens
P16152
pH 7.4, 37°C
0.0061
3-[2,3-dihydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-5,7-dihydroxy-4H-chromen-4-one
Homo sapiens
P16152
pH 7.4, 37°C
0.0011
3-[2-(2,4-dihydroxyphenyl)-1-(4-hydroxybenzyl)-2-oxoethyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Homo sapiens
P16152
pH 7.4, 37°C
0.0013
4-amino-1-tert-butyl-3-(2-hydroxyphenyl)pyrazolo[3,4-d]pyrimidine
Homo sapiens
-
for menadione metabolism
0.0021
5beta-cholanoic acid
Canis lupus familiaris
-
pH 6.0
0.037 - 0.219
7-monohydroxyethylrutoside
0.008
7-O-beta-D-glucopyranos2-ulosyl-quercetin
Homo sapiens
P16152
pH 7.4, 37°C
0.0127
Biochanin A
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.023
bromosulfophthalein
Canis lupus familiaris
-
pH 6.0
0.00067
chrysin
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.015
Dehydrolithocholic acid
Canis lupus familiaris
-
pH 6.0
0.055
Flufenamic acid
Canis lupus familiaris
-
pH 6.0
0.0061
genistein
Canis lupus familiaris
-
pH 6.0
0.017
kaempferol
Canis lupus familiaris
-
pH 6.0
0.0033
lithocholic acid
Canis lupus familiaris
-
pH 6.0
0.011
myristic acid
Canis lupus familiaris
-
pH 6.0
0.2 - 2
NADP+
0.0215
naringenin
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.0062 - 0.043
quercetin
0.0065
quercitrin
Homo sapiens
P16152
pH 7.4, 37°C
0.00327
radiciol
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.0021
rutin
Homo sapiens
P16152
pH 7.4, 37°C
0.0004
triclosan
Homo sapiens
-
pH 6.9, temperature not specified in the publication
0.035
Valproic acid
Canis lupus familiaris
-
pH 6.0
0.00378
wedelolactone
Homo sapiens
-
pH 6.9, temperature not specified in the publication