1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

Turnover Number

Turnover Number on EC 1.1.1.184 - carbonyl reductase (NADPH)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
177
(R)-2-butanol
-
pH 7.5, 37°C
123
(S)-2-butanol
-
pH 7.5, 37°C
3.47 - 6.7
1,2-naphthoquinone
0.25 - 0.55
1,4-Naphthoquinone
0.00027 - 0.00062
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
2.72 - 2.89
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
17
1-phenylisatin
-
pH 6.0
6.8 - 20
16-ketoestrone
16.4
2,2,2-trifluoroacetophenone
pH 9.0, 70°C, recombinant enzyme
26
2,3-Butanediol
-
pH 7.5, 37°C
23
2,3-heptanedione
-
pH 6.0
0.32 - 24
2,3-Hexanedione
10.7 - 36.7
2,3-Pentanedione
149
2-butanol
-
pH 7.5, 37°C
86
2-butanone
-
pH 7.5, 37°C
1.13 - 6.76
2-hydroxyacetophenone
5
2-Pentanol
-
pH 7.5, 37°C
18
2-Pentanone
-
pH 7.5, 37°C
243
2-propanol
-
pH 7.5, 37°C
6.75
3-glutathionyl-4-hydroxynonanal
-
pH 8.4, 37°C
-
30.5
3-glutathionyl-hexanal
-
pH 8.4, 25°C
-
30.8
3-glutathionyl-nonanal
-
pH 8.4, 25°C
-
190.8
3-glutathionyl-propanal
-
pH 8.4, 25°C
-
1 - 2.02
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
0.009167 - 17
4-benzoylpyridine
17
4-hexanoylpyridine
-
pH 6.0
0.0098 - 3.48
4-Nitrobenzaldehyde
220
4-oxonon-2-enal
-
pH 7.4, 37°C, recombinant enzyme
1.27 - 36.2
9,10-phenanthrenequinone
0.07
9-cis-retinal
-
pH 7.4
13
acenaphthenequinone
-
pH 6.0
183
acetoin
-
pH 7.5, 37°C
0.18
acetone
pH 6.5, 25°C
0.08
all-trans-retinal
-
pH 7.4
0.01
all-trans-retinol
-
pH 7.4
32
benzoylformic acid ethyl ester
-
pH 6.0
6
Cycloheptanone
-
pH 7.5, 37°C
5
Cyclohexanol
-
pH 7.5, 37°C
86
cyclohexanone
-
pH 7.5, 37°C
106
Cyclopentanol
-
pH 7.5, 37°C
80
Cyclopentanone
-
pH 7.5, 37°C
0.48 - 91
daunorubicin
609
diacetyl
-
pH 7.5, 37°C
0.0103 - 0.21
doxorubicin
0.45
estrone
pH 6.5, 25°C
12.5
ethyl 2-methylacetoacetate
pH 9.0, 70°C, recombinant enzyme
11.2
ethyl 2-oxo-4-phenylbutyrate
pH 9.0, 70°C, recombinant enzyme
1.05
ethyl 4-chloro-3-oxobutanoate
pH 6.0, 50°C
8.6
glutathione-4-oxonon-2-enal
-
pH 7.4, 37°C, recombinant enzyme
10
heptanophenone
-
pH 6.0
25
hexanophenone
-
pH 6.0
0.17 - 14
isatin
0.0092 - 246
menadione
2.5 - 4
methyl glyoxal
23.8
methylglyoxal
pH 7.0, 25°C
15
n-butyrophenone
-
pH 6.0
1.13 - 120
NADH
243
NADP+
-
pH 7.5, 37°C
1.21 - 870
NADPH
0.38 - 1.67
oracin
2.5 - 3.28
p-toluquinone
39.3
Phenylglyoxal
pH 7.0, 25°C
129
propanone
-
pH 7.5, 37°C
0.68 - 25
prostaglandin E2
3.5
S-1-phenyl-1-butanol
-
pH 7.4
2.02 - 20.45
S-nitrosoglutathione
0.6
testosterone
pH 6.5, 25°C
11
valerophenone
-
pH 6.0