1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, ketoreductase, KLCR1, KR, LCR, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

Turnover Number

Turnover Number on EC 1.1.1.184 - carbonyl reductase (NADPH)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
177
(R)-2-butanol
Methanobacterium palustre
-
pH 7.5, 37°C
123
(S)-2-butanol
Methanobacterium palustre
-
pH 7.5, 37°C
3.47 - 6.7
1,2-naphthoquinone
0.25 - 0.55
1,4-Naphthoquinone
0.00027 - 0.00062
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
2.72 - 2.89
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
17
1-phenylisatin
Canis lupus familiaris
-
pH 6.0
6.8 - 20
16-ketoestrone
16.4
2,2,2-trifluoroacetophenone
Thermotoga maritima
Q9X265
pH 9.0, 70°C, recombinant enzyme
26
2,3-Butanediol
Methanobacterium palustre
-
pH 7.5, 37°C
23
2,3-heptanedione
Canis lupus familiaris
-
pH 6.0
0.32 - 24
2,3-Hexanedione
10.7 - 36.7
2,3-Pentanedione
149
2-butanol
Methanobacterium palustre
-
pH 7.5, 37°C
86
2-butanone
Methanobacterium palustre
-
pH 7.5, 37°C
1.13 - 6.76
2-hydroxyacetophenone
5
2-Pentanol
Methanobacterium palustre
-
pH 7.5, 37°C
18
2-Pentanone
Methanobacterium palustre
-
pH 7.5, 37°C
243
2-propanol
Methanobacterium palustre
-
pH 7.5, 37°C
0.009167 - 17
4-benzoylpyridine
17
4-hexanoylpyridine
Canis lupus familiaris
-
pH 6.0
0.0098 - 1.087
4-Nitrobenzaldehyde
220
4-oxonon-2-enal
Homo sapiens
-
pH 7.4, 37°C, recombinant enzyme
3.57 - 36.2
9,10-phenanthrenequinone
0.07
9-cis-retinal
Canis lupus familiaris
-
pH 7.4
13
acenaphthenequinone
Canis lupus familiaris
-
pH 6.0
183
acetoin
Methanobacterium palustre
-
pH 7.5, 37°C
0.08
all-trans-retinal
Canis lupus familiaris
-
pH 7.4
0.01
all-trans-retinol
Canis lupus familiaris
-
pH 7.4
32
benzoylformic acid ethyl ester
Canis lupus familiaris
-
pH 6.0
6
Cycloheptanone
Methanobacterium palustre
-
pH 7.5, 37°C
5
Cyclohexanol
Methanobacterium palustre
-
pH 7.5, 37°C
86
cyclohexanone
Methanobacterium palustre
-
pH 7.5, 37°C
106
Cyclopentanol
Methanobacterium palustre
-
pH 7.5, 37°C
80
Cyclopentanone
Methanobacterium palustre
-
pH 7.5, 37°C
1.19 - 91
daunorubicin
609
diacetyl
Methanobacterium palustre
-
pH 7.5, 37°C
0.0103 - 0.21
doxorubicin
12.5
ethyl 2-methylacetoacetate
Thermotoga maritima
Q9X265
pH 9.0, 70°C, recombinant enzyme
11.2
ethyl 2-oxo-4-phenylbutyrate
Thermotoga maritima
Q9X265
pH 9.0, 70°C, recombinant enzyme
8.6
glutathione-4-oxonon-2-enal
Homo sapiens
-
pH 7.4, 37°C, recombinant enzyme
10
heptanophenone
Canis lupus familiaris
-
pH 6.0
25
hexanophenone
Canis lupus familiaris
-
pH 6.0
0.17 - 14
isatin
0.0092 - 246
menadione
23.8
methylglyoxal
Gluconobacter oxydans
Q5FQJ0
pH 7.0, 25°C
15
n-butyrophenone
Canis lupus familiaris
-
pH 6.0
1.13 - 120
NADH
243
NADP+
Methanobacterium palustre
-
pH 7.5, 37°C
1.21 - 870
NADPH
39.3
Phenylglyoxal
Gluconobacter oxydans
Q5FQJ0
pH 7.0, 25°C
129
propanone
Methanobacterium palustre
-
pH 7.5, 37°C
18 - 25
prostaglandin E2
3.5
S-1-phenyl-1-butanol
Canis lupus familiaris
-
pH 7.4
2.02 - 20.45
S-nitrosoglutathione
11
valerophenone
Canis lupus familiaris
-
pH 6.0