1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, ketoreductase, KLCR1, KR, LCR, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

Specific Activity

Specific Activity on EC 1.1.1.184 - carbonyl reductase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.009
-
substrate 4-tert-butylacetophenone, mutant Q245L
0.011
-
substrate 4-methylacetophenone, wild-type; substrate 4-tert-butylacetophenone, wild-type
0.013
-
substrate 4-bromoacetophenone, wild-type
0.014
-
substrate 4-fluoroacetophenone, wild-type
0.015 - 1.14
substrate specificity, overview
0.016
-
substrate 4-methoxyacetophenone, mutant Q245H
0.02
-
substrate 4-chloroacetophenone, wild-type; substrate 4-methoxyacetophenone, mutant Q245L; substrate 4-methoxyacetophenone, wild-type; substrate 4-methylacetophenone, mutant Q245L
0.025
-
substrate 4-fluoroacetophenone, mutant Q245P; substrate 4-methylacetophenone, mutant Q245H
0.028
-
substrate acetophenone, wild-type
0.032
-
substrate 4-tert-butylacetophenone, mutant Q245H
0.036
-
substrate 4-fluoroacetophenone, mutant Q245L
0.039
-
substrate acetophenone, mutant Q245P
0.045
-
substrate 4-methylacetophenone, mutant Q245P
0.047
-
substrate 4-bromoacetophenone, mutant Q245L
0.062
-
substrate 4-methoxyacetophenone, mutant Q245P
0.067
-
substrate 4-chloroacetophenone, mutant Q245L
0.072
-
substrate 4-fluoroacetophenone, mutant Q245H
0.073
-
substrate 1-phenylethanonee, pH 6.5, temperature not specified in the publication
0.074
-
substrate 1-(4-chlorophenyl)ethanone, pH 6.5, temperature not specified in the publication
0.084
-
substrate 4-tert-butylacetophenone, mutant Q245P
0.085
-
substrate acetophenone, mutant Q245H
0.086
-
substrate acetophenone, mutant Q245L
0.1
-
recombinant enzyme, substrate phenyl 3-oxobutyrate
0.12
-
recombinant enzyme, substrate trifluoromethyl 3-oxobutyrate
0.18
-
recombinant enzyme, substrate tert-butyl 3-oxobutyrate
0.2
-
recombinant enzyme, substrate ethyl 3-oxobutyrate
0.203
-
substrate 4-bromoacetophenone, mutant Q245H
0.238
-
substrate 4-chloroacetophenone, mutant Q245H
0.309
-
substrate 4-chloroacetophenone, mutant Q245P
0.403
-
substrate 4-bromoacetophenone, mutant Q245P
0.5
-
purified recombinant enzyme
0.522
-
substrate ethyl 3-oxopentanoate, pH 6.5, temperature not specified in the publication
0.8
-
recombinant enzyme, substrate isopropyl 3-oxobutyrate
1.2
substrate ethyl pyruvate, pH 7.0, 25C
1.4
-
recombinant enzyme, substrate chloromethyl 3-oxobutyrate
2.8
-
purified recombinant mutant S1M1
3 - 8
-
purified enzyme
3.4
substrate methylglyoxal, pH 7.0, 25C
3.5
purified recombinant enzyme, substrate 3,4-hexandione, pH 7.0, 30C
4.7
substrate isoamyl pyruvate, pH 7.0, 25C
5.4
substrate 1-phenyl-1,2-propanedione, pH 7.0, 25C
6
substrate 2,3-butanedione, pH 7.0, 25C
6.3
-
substrate 4-chlorobenzaldehyde, pH 6.5, temperature not specified in the publication
6.5
substrate 2,3-hexanedione, pH 7.0, 25C
7
-
substrate 4-fluorobenzaldehyde, pH 6.5, temperature not specified in the publication
7.9
pH 9.0, 55C; purified recombinant His-tagged enzyme, pH 9.0, 70C
9.9
-
purified recombinant mutant S1M4
10.9
-
substrate 4-bromobenzaldehyde, pH 6.5, temperature not specified in the publication
12.6
-
pH 7.0, 30C
17
substrate 2,3-pentanedione, pH 7.0, 25C
19.1
substrate phenylglyoxal, pH 7.0, 25C
27.8
-
purified recombinant wild-type enzyme
35
substrate methylglyoxal, pH 7.0, 25C
50.1
substrate 2,3-hexanedione, pH 7.0, 25C
50.8
-
purified enzyme
60
substrate 2,3-butanedione, pH 7.0, 25C
63.1
substrate isoamyl pyruvate, pH 7.0, 25C
65
substrate 2,5-diketo-D-gluconate, pH 7.0, 25C
69.6
substrate 2,3-pentanedione, pH 7.0, 25C
74.7
substrate phenylglyoxal, pH 7.0, 25C
75.4
substrate 1-phenyl-1,2-propanedione, pH 7.0, 25C
75.9
-
pH 7.4, 30C
80
purified recombinant enzyme, substrate 2,3-hexandione, pH 7.0, 30C
89
purified recombinant enzyme, substrate 2,3-heptandione, pH 7.0, 30C
92.8
substrate ethyl pyruvate, pH 7.0, 25C
125.3
Cylindrocarpon sclerotigenum
-
purified enzyme
161.6
substrate daunorubicin, pH 7.4, 37C
337
-
pH 6.0, 30C
468
purified recombinant enzyme, substrate dihydroxyacetone, pH 7.0, 30C; substrate dihydroxyacetone, 30C, pH 7.0
1502
-
substrate ethyl 4-chloro-3-oxobutanoate, pH 6.5, temperature not specified in the publication
1533
substrate 2,3-butanedione, pH 7.4, 37C
additional information