Disease on EC 1.1.1.184 - carbonyl reductase (NADPH)

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Carcinoma, Hepatocellular
Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells.
Cardiotoxicity
Carbonyl reductase 1 as a novel target of (-)-epigallocatechin gallate against hepatocellular carcinoma.
DNA sequence variants in the carbonyl reductase 1 (cbr1) gene in seven breeds of Canis lupus familiaris.
EXPRESSION OF THE ANTHRACYCLINE METABOLIZING ENZYME CARBONYL REDUCTASE 1 (CBR1) IN HEARTS FROM DONORS WITH DOWN SYNDROME.
Inhibition of Carbonyl Reductase 1 Safely Improves the Efficacy of Doxorubicin in Breast Cancer Treatment.
Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1.
Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1.
Dehydration
An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing ?-ketone in polyketide starter unit biosynthesis.
Inhibition of mammalian fatty acid synthetase activity by NADP involves decreased mobility of the 4'-phosphopantetheine prosthetic group.
Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase.
Diabetes Mellitus, Type 2
Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.
Down Syndrome
EXPRESSION OF THE ANTHRACYCLINE METABOLIZING ENZYME CARBONYL REDUCTASE 1 (CBR1) IN HEARTS FROM DONORS WITH DOWN SYNDROME.
Drug Resistant Epilepsy
CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies.
Gastrointestinal Neoplasms
Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers.
Heart Failure
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Insulin Resistance
Genetic variation in the carbonyl reductase 3 gene confers risk of type 2 diabetes and insulin resistance: a potential regulator of adipogenesis.
Keloid
Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization.
Kidney Failure, Chronic
Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease.
Leukemia
Carbonyl Reductase 1 Offers a Novel Therapeutic Target to Enhance Leukemia Treatment by Arsenic Trioxide.
Leukemia, Myeloid, Acute
Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia.
Lung Neoplasms
Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene.
Malformations of Cortical Development
CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies.
Neoplasm Metastasis
Bcl-x(L)-mediated changes in metabolic pathways of breast cancer cells: from survival in the blood stream to organ-specific metastasis.
Neoplasms
Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century.
Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy.
Decreased expression of carbonyl reductase 1 promotes ovarian cancer growth and proliferation.
Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer.
Inhibitory effect of carbonyl reductase 1 on ovarian cancer growth via tumor necrosis factor receptor signaling.
Regulation of Human Carbonyl Reductase 3 (CBR3; SDR21C2) Expression by Nrf2 in Cultured Cancer Cells.
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Ovarian Neoplasms
Decreased expression of carbonyl reductase 1 promotes ovarian cancer growth and proliferation.
Gene therapy for ovarian cancer using carbonyl reductase 1 DNA with a polyamidoamine dendrimer in mouse models.
Inhibitory effect of carbonyl reductase 1 on ovarian cancer growth via tumor necrosis factor receptor signaling.
Tuberculosis
Crystal structure of FabG4 from Mycobacterium tuberculosis reveals the importance of C-terminal residues in ketoreductase activity.
F420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.
Tuberous Sclerosis
CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies.