1.1.1.184: carbonyl reductase (NADPH)

This is an abbreviated version, for detailed information about carbonyl reductase (NADPH), go to the full flat file.

Reaction

R-CHOH-R'
+
NADP+
=
R-CO-R'
+
NADPH
+
H+

Synonyms

15-hydroxyprostaglandin dehydrogenase [NADP+], 2,5-diketo-D-gluconic acid reductase, Adipocyte P27 protein, aldehyde reductase 1, aldehyde reductase I, aldo-keto reductase, ALR3, AP27, carbonyl reductase, carbonyl reductase (NADPH), carbonyl reductase 1, carbonyl reductase 3, carbonyl reductase S1, CBR, CBR 1, CBR 3, CBR1, CBR3, CHCR, CHCR1, CHCR2, CHCR3, CR, CSCR1, Gox0644, Gox1615, hCBR1, ketoreductase, KLCR1, KR, LCR, LOC415661, LOC610164, microsomal carbonyl reductase, More, NADP+-dependent ADH, NADPH-carbonyl reductase, NADPH-dependent carbonyl reductase, NADPH-dependent carbonyl reductase S1, NCCR, nonspecific NADPH-dependent carbonyl reductase, peroxisomal-type carbonyl reductase, PHCR, prostaglandin 9-ketoreductase, Prostaglandin-E2 9-reductase, PTCR, R-specific carbonyl reductase, reductase S1, reductase, carbonyl, RLCR, SCR, SDR21C1, secondary-alcohol: NADP+-oxidoreductase, short-chain (S)-1-phenyl-1,2-ethanediol dehydrogenase, short-chain carbonyl reductase, sniffer, SSCR, tetrameric carbonyl reductase, Tm1743, Tm_1743, xenobiotic carbonyl reductase, xenobiotic ketone reductase, YGL039w1, YGL039w2, YtbE

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.184 carbonyl reductase (NADPH)

KM Value

KM Value on EC 1.1.1.184 - carbonyl reductase (NADPH)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.2
(R)-2-butanol
-
pH 7.5, 37°C
4.5
(S)-2-butanol
-
pH 7.5, 37°C
0.07 - 0.117
1,2-naphthoquinone
0.16 - 1.13
1,4-benzoquinone
0.0073 - 0.54
1,4-Naphthoquinone
0.156 - 0.469
1-(3-methyl-1,4-dioxidoquinoxalin-2-yl)ethanone
0.105 - 0.116
1-(3-methyl-4-oxidoquinoxalin-2-yl)ethanone
0.04
1-phenyl-1,2-propanedione
-
pH 6.0, recombinant enzyme
0.004 - 0.009
1-phenylisatin
0.036 - 0.099
16-ketoestrone
0.3
2,2,2-trifluoroacetophenone
pH 9.0, 70°C, recombinant enzyme
18
2,3-Butanediol
-
pH 7.5, 37°C
1.8
2,3-Butanedione
-
-
0.22
2,3-heptanedione
-
pH 6.0
0.47
2,3-hexandione
-
pH 6.0, recombinant enzyme
0.06 - 0.62
2,3-Hexanedione
3.9 - 33
2,3-Pentanedione
0.93 - 1.7
2-benzoylpyridine
3.5
2-butanol
-
pH 7.5, 37°C
9.5
2-butanone
-
pH 7.5, 37°C
0.59 - 10.27
2-hydroxyacetophenone
0.57
2-methyl-1,4-benzoquinone
-
-
0.8
2-nitrobenzaldehyde
-
-
14
2-Pentanone
-
pH 7.5, 37°C
3
2-propanol
-
pH 7.5, 37°C
0.33 - 0.76
3-benzoylpyridine
0.033
3-glutathionyl-4-hydroxynonanal
-
pH 8.4, 37°C
-
0.0238
3-glutathionyl-hexanal
-
pH 8.4, 25°C
-
0.0065
3-glutathionyl-nonanal
-
pH 8.4, 25°C
-
0.0207
3-glutathionyl-propanal
-
pH 8.4, 25°C
-
5.85 - 7.84
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
1.55
4-acetylpyridine
-
-
0.000000053 - 3.3
4-benzoylpyridine
0.38 - 0.65
4-formylbenzoic acid
-
Km depending on enzyme form
0.044 - 0.09
4-hexanoylpyridine
0.004 - 2.5
4-Nitroacetophenone
0.12 - 2
4-Nitrobenzaldehyde
0.345
4-oxonon-2-enal
-
pH 7.4, 37°C, recombinant enzyme
0.05 - 0.1
5alpha-androstan-17beta-ol-3-one
0.15
5alpha-androstane-3,17-dione
-
form CR2
0.002 - 0.078
9,10-phenanthrenequinone
0.002
9,10-phenanthrenquinone
-
-
-
0.003
9,10-phenanthroline
-
pH 5.5, 37°C
0.087
9-cis-retinal
-
pH 7.4
0.02
acenaphthenequinone
-
pH 6.0
0.039 - 5.1
acetaldehyde
0.92
acetohexamide
-
pH 6.5, 30°C
16
acetoin
-
pH 7.5, 37°C
0.05 - 3.1
acetone
0.083
Adrenochrome
-
pH 6.0, 37°C
0.009
all-trans-retinal
-
pH 7.4
0.086
all-trans-retinol
-
pH 7.4
1.44
befunolol
-
pH 6.5, 30°C
0.031 - 0.33
Benzalacetone
0.13
benzil
-
pH 6.0, recombinant enzyme
0.008
benzoylformic acid ethyl ester
-
pH 6.0
0.3
benzoylpyridine
-
-
0.084
butyrophenone
-
pH 6.0, 37°C
0.12 - 250
crotonaldehyde
6.5
cyclohexanone
-
pH 7.5, 37°C
4.5
Cyclopentanol
-
pH 7.5, 37°C
4.2
Cyclopentanone
-
pH 7.5, 37°C
0.043 - 3
daunorubicin
0.0136 - 7.4
diacetyl
0.132 - 0.335
doxorubicin
0.001
estrone
pH 6.5, 25°C
4.1
ethyl 2-chloro-3-oxobutanoate
-
-
4.9
ethyl 2-methylacetoacetate
pH 9.0, 70°C, recombinant enzyme
0.319
ethyl 2-oxo-4-phenylbutanoate
-
pH 7.0, 30°C
6
ethyl 2-oxo-4-phenylbutyrate
pH 9.0, 70°C, recombinant enzyme
61
ethyl 2-oxobutanoate
-
-
0.0026 - 4.6
ethyl 4-chloro-3-oxobutanoate
21
ethyl pyruvate
-
-
0.329
glutathione-4-oxonon-2-enal
-
pH 7.4, 37°C, recombinant enzyme
0.018 - 0.078
heptanophenone
0.011 - 0.037
hexanophenone
0.02
hexaphenone
-
pH 6.0, 25°C, recombinant enzyme
0.0008 - 4
isatin
10
ketopantoyl lactone
-
-
0.52
loxoprofen
-
pH 6.5, 30°C
0.000000067 - 0.527
menadione
39
methyl 2-chloro-3-oxobutanoate
-
-
10
methyl 4-chloro-3-oxobutanoate
-
-
0.43 - 1.6
methyl glyoxal
0.012 - 0.057
methyl-1,4-benzoquinone
2.2
methylglyoxal
pH 7.0, 25°C
0.029 - 0.17
n-butyrophenone
0.062 - 8.67
NADH
0.021
NADP+
-
pH 7.5, 37°C
0.00214 - 10.27
NADPH
0.031
nonanophenone
-
pH 6.0, recombinant enzyme
0.034 - 0.096
oracin
0.64
p-nitrobenzaldehyde
-
recombinant protein purified from E. coli
0.176 - 0.18
p-toluquinone
1 - 5
Phenylglyoxal
0.4
propanone
-
pH 7.5, 37°C
0.249 - 0.89
propiophenone
0.14 - 0.21
Prostaglandin B2
-
Km depending on enzyme form
0.45
prostaglandin E1
-
enzyme form CR8
0.03 - 0.32
prostaglandin E2
0.09
pyridin-4-yl hexanoate
-
pH 6.0, 25°C, recombinant enzyme
0.015 - 0.13
pyridine 3-aldehyde
0.002
pyridine 4-aldehyde
-
cofactor NADPH
1.8 - 11.4
Pyridine-3-aldehyde
0.5 - 1.4
Pyridine-4-aldehyde
0.49 - 2
pyridine-4-carboxaldehyde
0.028
S-1-phenyl-1-butanol
-
pH 7.4
0.028 - 2.93
S-nitrosoglutathione
0.04
testosterone
pH 6.5, 25°C
0.015 - 0.017
ubiquinone-1
-
Km depending on enzyme form
0.01 - 0.052
valerophenone
additional information
additional information
-