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5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
5'-nucleotide phosphodiesterase
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5'-phosphodiesterase
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5'NPDE
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5'-nucleotide phosphodiesterase/alkaline phosphodiesterase
alkaline phosphodiesterase
Ap3A (Ap4A) hydrolase
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calcium-dependent phosphodiesterase 1C
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cleavage/polyadenylation specificity factor
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CPSF-73
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the 73 kDa subunit of cleavage/polyadenylation specificity factor
cRNPMase-5'-PDase
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FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
cyclic nucleotide phosphodiesterase 1
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cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase I
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FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
ecto-nucleotide pyrophosphatase/phosphodiesterase 1
ectonucleotide pyrophosphatase phosphodiesterase 1
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ectonucleotide pyrophosphatase/phosphodiesterase 1
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ectonucleotide pyrophosphate/phosphodiesterase-1
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liver alkaline phosphodiesterase 1
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liver nucleotide phosphodiesterase
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NPP/PDE
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nucleotide pyrophosphatase/phosphodiesterase I
nucleotide phosphodiesterase
nucleotide phosphodiesterase/pyrophosphatase
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nucleotide pyrophosphatase/alkaline phosphodiesterase I
nucleotide pyrophosphatase/phosphodiesterase 1
nucleotide pyrophosphatase/phosphodiesterase I
nucleotide pyrophosphatase/phosphodiesterase-1
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nucleotide pyrophosphatase/phosphodiesterase-2
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nucleotide pyrophosphatase/phosphodiesterase-3
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orthophosphoric diester phosphohydrolase
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phosphonate monoester hydrolase/phosphodiesterase
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phosphoric diester hydrolase
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plasma cell antigen 1
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plasma cell membrane glycoprotein
plasma cell membrane protein-1
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sphingomyelin phosphodiesterase, acid-like 3A
tyrosyl DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
tyrosyl-DNA phosphodiesterase I
tyrosyl-DNA-phosphodiesterase I
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5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
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5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
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alkaline phosphodiesterase
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alkaline phosphodiesterase
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alkaline phosphodiesterase
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alkaline phosphodiesterase I
alkaline phosphodiesterase
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alkaline phosphodiesterase
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alkaline phosphodiesterase I
alkaline phosphodiesterase
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alkaline phosphodiesterase
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alkaline phosphodiesterase I
ecto-NPPase
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ecto-nucleotide pyrophosphatase/phosphodiesterase 1
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ecto-nucleotide pyrophosphatase/phosphodiesterase 1
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ENPP1
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exonuclease I
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NPP1
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NPP3
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nucleotide phosphodiesterase
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nucleotide phosphodiesterase
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nucleotide phosphodiesterase
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nucleotide pyrophosphatase/alkaline phosphodiesterase I
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EC 3.6.1.9 /EC 3.1.4.1
nucleotide pyrophosphatase/alkaline phosphodiesterase I
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EC 3.6.1.9 /EC 3.1.4.1
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nucleotide pyrophosphatase/phosphodiesterase 1
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nucleotide pyrophosphatase/phosphodiesterase 1
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nucleotide pyrophosphatase/phosphodiesterase 1
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nucleotide pyrophosphatase/phosphodiesterase I
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EC 3.6.1.9 /EC 3.1.4.1
nucleotide pyrophosphatase/phosphodiesterase I
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membrane alkaline phosphodiesterase is the same enzyme as nucleotide pyrophosphatase
PC-1
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PC-1
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PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity
PC-1
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PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity
PC-1
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PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity
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PC-1
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PC-1, plasma-cell differentiation antigen-1, a trifunctional enzyme, displaying a phosphodiesterase I /nucleotide pyrophosphatase activity, a protein threonine kinase activity, and a nucleotide-stimulated protein threonine phosphatase activity
PC-1
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PC-1, plasma-cell differentiation antigen-1, membrane glycoprotein, has 5'-nucleotide phosphodiesterase and nucleotide pyrophosphatase activity
PDE I
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PDE1
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PDE1C
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isoform
phosphodiesterase
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phosphodiesterase 1
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phosphodiesterase 1A
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phosphodiesterase 1A
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phosphodiesterase 1C
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phosphodiesterase 1C
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isoform 1C
plant exonuclease I
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plasma cell membrane glycoprotein
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plasma cell membrane glycoprotein
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RNase J1
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SMPDL3A
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sphingomyelin phosphodiesterase, acid-like 3A
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sphingomyelin phosphodiesterase, acid-like 3A
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sphingomyelin phosphodiesterase, acid-like 3A
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TDP1
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TDP1
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714101, 714113, 715042, 716301, 716603, 728098, 729329, 729624, 729979, 730160, 730169
tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase 1
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tyrosyl-DNA phosphodiesterase I
E2REL5
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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tyrosyl-DNA phosphodiesterase I
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additional information
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the enzyme belongs to a family of enzymes with nucleoside triphosphate pyrophophohydrolase, NTPPPH, activity
additional information
tyrosyl DNA phosphodiesterase 1 is a member of phospholipase D, PLD, superfamily
additional information
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overview on nomenclature and synonyms
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
[nucleotide]n + H2O = [nucleotide]m + nucleotide
mechanism
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
mechanism, overview
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
mode of action
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
the enzyme may be able to recognize nucleoside 5'-monophosphates in the substrates and nick them even if the phosphodiester bonds are closed covalently, although the mode of action of this enzyme on oligo- or polynucleotides is typically exonucleolytic
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
ping-pong type mechanism, with participation of a covalent enzyme intermediate
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
active site residue is threonine
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
enzyme is an exonuclease which needs a free end of an oligonucleotide chain for activity
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
PC-1, enzymic activities and regulation of PC-1
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
mechanism, transition state
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[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview
E2REL5
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview. The enzyme's N-terminal catalytic His182 functions as a nucleophile (Hisnuc) to attack the 3'-phospho-tyrosyl linkage. This results in dissociation of the tyrosine (and by extension Topo1) from the DNA end and the formation of a enzyme-DNA covalent reaction intermediate via a 3'-phospho-histidyl linkage
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview. The enzyme's N-terminal catalytic His263 functions as a nucleophile (Hisnuc) to attack the 3'-phospho-tyrosyl linkage. This results in dissociation of the tyrosine (and by extension Topo1) from the DNA end and the formation of a enzyme-DNA covalent reaction intermediate via a 3'-phospho-histidyl linkage
[nucleotide]n + H2O = [nucleotide]m + nucleotide
catalytic mechanism, the enzyme has a unique catalytic cycle, structure-function analysis overview. The enzyme's N-terminal catalytic His182 functions as a nucleophile (Hisnuc) to attack the 3'-phospho-tyrosyl linkage. This results in dissociation of the tyrosine (and by extension Topo1) from the DNA end and the formation of a enzyme-DNA covalent reaction intermediate via a 3'-phospho-histidyl linkage
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(5'-GATCTAAAAGACTT-3')-phosphotyrosine + H2O
(5'-GATCTAAAAGACTT-3')-phosphate + L-tyrosine
Substrates: -
Products: -
?
10-hydroxydecyl-oligonucleotide + H2O
?
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Substrates: different sequences of the oligonucleotides, overview. The enzyme catalyzes the cleavage of the synthetic analogue of the apurinic/apyrimidinic site
Products: -
?
2',3'-cAMP + H2O
?
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Substrates: -
Products: -
?
2-hydroxypropyl-p-nitrophenyl phosphate + H2O
2-hydroxypropyl-p-nitrophenol + phosphate
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Substrates: -
Products: -
?
2-naphthyl chloromethylphosphonate + H2O
2-naphthol + chloromethylphosphonic acid
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Substrates: -
Products: -
?
2-naphthyl methylphosphonate + H2O
2-naphthol + methylphosphonic acid
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Substrates: -
Products: -
?
2-naphthyl phenylphosphonate + H2O
2-naphthol + benzenephosphonic acid
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Substrates: -
Products: -
?
3'-O-acetyl-5'-O-[hydroxy(4-nitrophenoxy)phosphoryl]thymidine + H2O
p-nitrophenol + 3'-O-acetylthymidine 5'-phosphate
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Substrates: -
Products: -
?
3'-p-nitrophenylthymidine 3'-phosphate + H2O
3'-TMP + p-nitrophenol
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Substrates: -
Products: -
?
3'-phosphoadenosine 5'-phosphosulfate + H2O
?
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Substrates: -
Products: -
?
3'-phosphohistidyl-linked tyrosyl-DNA phosphodiesterase I-DNA complex + H2O
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Substrates: tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-histidyl bond formed between tyrosyl-DNA phosphodiesterase I and DNA
Products: -
?
3'-phosphotyrosyl-linked topoisomerase I-DNA complex + H2O
?
Substrates: tyrosyl-DNA phosphodiesterase I hydrolyzes the 3'phospho-tyrosyl bond formed between DNA topoisomerase I and DNA
Products: -
?
3-hydroxy-2(hydroxymethyl)-tetrahydrofuran-oligonucleotide + H2O
?
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Substrates: different sequences of the oligonucleotides, overview. The enzyme catalyzes the cleavage of the synthetic analogue of the apurinic/apyrimidinic site. In the case of tetrahydrofuran, the enzyme generates break with the 5'-tetrahydrofuran and the 3'-phosphate termini
Products: the enzyme generates a non-phosphorylated 5'-THF-terminus by the cleavage of 3-hydroxy-2(hydroxymethyl)-tetrahydrofuran-containing DNA
?
4-methylumbelliferyl phenylphosphonate + H2O
4-methylumbelliferone + phenylphosphonic acid
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Substrates: -
Products: -
?
4-methylumbelliferyl thymidine 5'-phosphate + H2O
4-methylumbelliferone + 5'-TMP
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Substrates: -
Products: -
?
4-nitrophenyl deoxythymidine 5'-phosphate + H2O
4-nitrophenol + deoxythymidine 5'-phosphate
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Substrates: -
Products: -
?
4-nitrophenyl phenyl phosphonate + H2O
4-nitrophenol + phenyl phosphonate
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Substrates: -
Products: -
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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Substrates: -
Products: -
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4-nitrophenyl phosphocholine + H2O
4-nitrophenol + phosphocholine
Substrates: secreted recombinant human SMPDL3A hydrolyzes 4-nitrophenyl phosphorylcholine, a synthetic analogue of the phosphorylcholine headgroup of lipids such as sphingomyelin and phosphatidylcholine
Products: -
?
4-nitrophenyl phosphorothioate + H2O
?
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Substrates: -
Products: -
?
4-nitrophenyl sulfate + H2O
?
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Substrates: -
Products: -
?
4-nitrophenyl uridine 5'-phosphate + H2O
4-nitrophenol + uridine 5'-phosphate
5'-(5,6-FAM-aacgtcagggtcttcc-BHQ1)-3' + H2O
?
5'-p-nitrophenyl deoxythymidine 5'-phosphate + H2O
5'-dTMP + p-nitrophenol
5'-p-nitrophenyl-2',3'-isopropyl-5'-UMP + H2O
?
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Substrates: -
Products: -
?
5'-p-nitrophenyladenosine 5'-phosphate + H2O
5'-AMP + p-nitrophenol
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
5'-p-nitrophenylnucleoside 5'-monophosphate + H2O
nucleoside 5'-monophosphate + p-nitrophenol
5'-p-nitrophenyluridine 5'-phosphate + H2O
5'-UMP + p-nitrophenol
5'-phosphotyrosyl-linked topoisomerase II-DNA complex + H2O
?
Substrates: tyrosyl-DNA phosphodiesterase I hydrolyzes the 5'phospho-tyrosyl bond formed between DNA topoisomerase II and DNA
Products: -
?
adenosine 5'-P1-tetraphospho-P4-5'''-adenosine + H2O
AMP + ATP
adenosine 5'-P1-tetraphospho-P4-5'''-guanosine + H2O
?
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Substrates: -
Products: -
?
adenosine 5'-phosphosulfate + H2O
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Substrates: -
Products: -
?
adenylyl-2',5'-adenosine + H2O
?
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
adenylyl-3',5'-adenosine + H2O
adenosine + 5'-AMP
adenylyl-3',5'-cytidine + H2O
adenosine 3'-phosphate + cytidine
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
adenylyl-3',5'-uridine + H2O
5'-UMP + adenosine
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Substrates: -
Products: -
?
adenylyl-3',5'-uridine + H2O
?
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
ADP + H2O
AMP + phosphate
ADP-ribose + H2O
5'-AMP + ribosyl monophosphate
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Substrates: -
Products: -
?
ADP-ribose + H2O
?
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Substrates: -
Products: -
?
ApA + H2O
5'-AMP + adenosine
ApC + H2O
5'-CMP + adenosine
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Substrates: -
Products: -
?
ApG + H2O
5'-GMP + adenosine
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Substrates: -
Products: -
?
ATP + H2O
5'-AMP + diphosphate
ATP + H2O
AMP + diphosphate
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Substrates: -
Products: -
?
bis(4-methylumbelliferyl) phosphate + H2O
?
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Substrates: -
Products: -
?
bis(4-nitrophenyl) phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
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Substrates: -
Products: -
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bis(4-nitrophenyl)phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
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Substrates: -
Products: -
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bis(p-nitrophenyl) phosphate + H2O
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bis-4-nitrophenyl phosphate + H2O
4-nitrophenol + 4-nitrophenyl phosphate
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Substrates: -
Products: -
?
bis-ethylene glycolyl-oligonucleotide + H2O
?
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Substrates: different sequences of the oligonucleotides, overview. The enzyme catalyzes the cleavage of the synthetic analogue of the apurinic/apyrimidinic site
Products: -
?
bis-p-nitrophenyl phosphate + H2O
p-nitrophenol + p-nitrophenyl phosphate
bis-p-nitrophenyl phosphate + H2O
p-nitrophenyl phosphate + nitrophenol
CDP-choline + H2O
?
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Substrates: -
Products: -
?
CpU + H2O
5'-UMP + cytidine
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Substrates: -
Products: -
?
cyclic 3',5'-mononucleotides + H2O
mononucleoside 5'-phosphate
cytidylyl-3',5'-adenosine + H2O
?
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
diadenosine 5',5'''-P1,P3-triphosphate + H2O
AMP + ADP
diadenosine diphosphate + H2O
?
-
Substrates: -
Products: -
?
diadenosine polyphosphate + H2O
AMP + adenosine polyphosphate-1
diethenoadenosine polyphosphate + H2O
ethenoadenosine 5'-monophosphate + ethenoadenosine (n-1)5'-polyphosphate
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Substrates: -
Products: -
?
diguanosine 5',5'''-P1,P4-tetraphosphate + H2O
?
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Substrates: -
Products: -
?
dinucleoside monophosphates + H2O
mononucleoside 5'-phosphate
dinucleoside polyphosphate + H2O
?
dinucleoside tetraphosphate + H2O
?
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Substrates: -
Products: -
?
DNA + H2O
DNA(n-1) + 2'-deoxynucleoside 5'-phosphate
downstream cleavage product-RNA + H2O
?
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Substrates: -
Products: -
?
FAD + H2O
AMP + FMN
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Substrates: -
Products: -
?
GDP-mannose + H2O
?
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Substrates: -
Products: -
?
GTP + H2O
?
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Substrates: -
Products: -
?
guanylyl-3',5'-adenosine + H2O
?
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Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
methyl 4-nitrophenyl phosphorothioate + H2O
?
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Substrates: -
Products: -
?
NADP+ + H2O
NAD+ + phosphate
oligonucleotides + H2O
oligonucleotides(n-1) + 5'-mononucleotides
p-nitrophenyl 5'-thymidine monophosphate + H2O
5'-TMP + p-nitrophenol
Substrates: -
Products: -
?
p-nitrophenyl 5'-thymidine monophosphate + H2O
p-nitrophenol + 5'-thymidine monophosphate
p-nitrophenyl chloromethylphosphonate + H2O
p-nitrophenol + chloromethylphosphonic acid
-
Substrates: -
Products: -
?
p-nitrophenyl ethyl phosphate + H2O
p-nitrophenol + ethyl hydrogen phosphate
-
Substrates: -
Products: -
?
p-nitrophenyl methylphosphonate + H2O
p-nitrophenol + methylphosphonic acid
-
Substrates: -
Products: -
?
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + benzenephosphonic acid
p-nitrophenyl phenylphosphonate + H2O
p-nitrophenol + phenylphosphonic acid
-
Substrates: -
Products: -
?
p-nitrophenylphosphorylcholine + H2O
p-nitrophenol + phosphorylcholine
p-nitrophenylthymidine 5'-phosphate + H2O
5'-TMP + p-nitrophenol
P1,P4-bis(5'-uridyl) tetraphosphate + H2O
UMP + uridine 5'-triphosphate
-
Substrates: -
Products: -
?
phosphonate ester + H2O
?
-
Substrates: -
Products: -
?
poly d(A-T)2 + H2O
?
-
Substrates: -
Products: -
?
poly G + H2O
5'-GMP
-
Substrates: -
Products: -
?
polymer synthesized from NAD+ + H2O
?
-
Substrates: chain length 27-30
Products: -
?
polynucleotides + H2O
polynucleotides(n-1) + 5'-mononucleotides
RNA + H2O
5'-GMP + 5'-AMP + ?
-
Substrates: -
Products: -
?
RNA + H2O
RNA(n-1) + nucleoside 5'-phosphate
thymidine 5'-monophosphate p-nitrophenylester + H2O
? + phosphate
-
Substrates: -
Products: -
?
thymidine 5'-monophosphate p-nitrophenylester + H2O
p-nitrophenol + TMP
-
Substrates: -
Products: -
?
thymidine 5'-triphosphate + H2O
?
-
Substrates: -
Products: -
?
TpT + H2O + H2O
5'-TMP + thymidine
-
Substrates: calf
Products: -
?
U(pU)6 + H2O
?
-
Substrates: -
Products: -
?
UDP-glucose + H2O
glucose-1-phosphate + 5'-UMP
uridylyl-3',5'-adenosine + H2O
?
-
Substrates: FS-44: bifunctional enzyme: cyclic-ribonucleotide phosphomutase-5'-phosphodiesterase
Products: -
?
UTP + H2O
UMP + diphosphate
-
Substrates: -
Products: -
?
additional information
?
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4-nitrophenyl uridine 5'-phosphate + H2O
4-nitrophenol + uridine 5'-phosphate
-
Substrates: -
Products: -
?
4-nitrophenyl uridine 5'-phosphate + H2O
4-nitrophenol + uridine 5'-phosphate
-
Substrates: -
Products: -
?
5'-(5,6-FAM-aacgtcagggtcttcc-BHQ1)-3' + H2O
?
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