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Literature summary for 3.1.4.1 extracted from

  • Cygnar, K.D.; Zhao, H.
    Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons (2009), Nat. Neurosci., 12, 454-462.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.1

Protein Variants

Protein Variants Comment Organism
additional information Pde1c-/- and Pde4a-/- knockout mutants to examine the role of the PDEs in olfactory transduction. Pde1c-/- OSNs (olfactory sensory neuron cilia) show reduced sensitivity and attenuated adaptation to repeated stimulation, suggesting that PDE1C may be involved in regulating sensitivity and adaptation Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+/calmodulin increased activity ca. 2.3fold Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
olfactory sensory neuron OSN cilia, PDE1C is detected primarily in the cilial layer, whereas PDE4A is detected in OSN cell bodies, dentrites and axons. The loss of one of the PDEs does not effect the occurrence of the other PDE. The localization of the PDE4A protein is normal in PDE1c-/- knockout mutant mice and vice versa Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 no basal activity is detected using the Pde1-/- knockout mutant in the standard assay and also the addition of Ca2+/calmodulin does not elicit any PDE acitivty Mus musculus
0.0015
-
 wild-type protein, in the absence of Ca2+, reflecting the basal PDE activity in the cilia, 37°C, pH not specified in the publication Mus musculus
0.0034
-
 wild-type cilial PDE, supplemented with Ca2+ and calmodulin, 2.3fold increased compared compared to the assay without Ca2+, 37°C, pH not specified in the publication Mus musculus

Synonyms

Synonyms Comment Organism
PDE1C
-
 Mus musculus
PDE4A
-
 Mus musculus
phosphodiesterase 1C
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction Pde1c-/- and Pde4a-/- knockout mutants to examine the role of the PDEs in olfactory transduction. Pde1c-/- OSNs (olfactory sensory neuron cilia) show reduced sensitivity and attenuated adaptation to repeated stimulation, suggesting that PDE1C may be involved in regulating sensitivity and adaptation Mus musculus