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Literature summary for 3.1.4.1 extracted from

  • Aerts, I.; Grobben, B.; Van Ostade, X.; Slegers, H.
    Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma (2011), Eur. J. Pharmacol., 654, 1-9.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q924C3
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Rattus norvegicus Wistar Q924C3
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-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
ecto-NPPase
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Rattus norvegicus
ecto-nucleotide pyrophosphatase/phosphodiesterase 1
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Rattus norvegicus
NPP1
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Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus cAMP-dependent inhibition of NPP1 expression not involving the the activator protein-1 motif present in the promoter of the rat NPP1 gene. (R,S)-Isoproterenol decreases the amount of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 protein by 75% and 81%, respectively. Contrary to downregulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 , an upregulation of glial fibrillary acidic protein, a differentiation marker for astrocytic cells is observed. Ca2+, PKA, PI 3-K/PKB/GSK-3, Epac/Rap1/PP2A and MAP kinase modules are not involved in the inhibition of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene expression down

General Information

General Information Comment Organism
metabolism (R,S)-isoproterenol decreases the amount of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 protein by 75% and 81%, respectively. Contrary to downregulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1, an upregulation of glial fibrillary acidic protein, a differentiation marker for astrocytic cells is observed. Ca2+, PKA, PI 3-K/PKB/GSK-3, Epac/Rap1/PP2A and MAP kinase modules are not involved in the inhibition of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene expression, overview Rattus norvegicus