Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q924C3 | - |
- |
Rattus norvegicus Wistar | Q924C3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C6 glioma cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
ecto-NPPase | - |
Rattus norvegicus |
ecto-nucleotide pyrophosphatase/phosphodiesterase 1 | - |
Rattus norvegicus |
NPP1 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | cAMP-dependent inhibition of NPP1 expression not involving the the activator protein-1 motif present in the promoter of the rat NPP1 gene. (R,S)-Isoproterenol decreases the amount of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 protein by 75% and 81%, respectively. Contrary to downregulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 , an upregulation of glial fibrillary acidic protein, a differentiation marker for astrocytic cells is observed. Ca2+, PKA, PI 3-K/PKB/GSK-3, Epac/Rap1/PP2A and MAP kinase modules are not involved in the inhibition of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene expression | down |
General Information | Comment | Organism |
---|---|---|
metabolism | (R,S)-isoproterenol decreases the amount of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 protein by 75% and 81%, respectively. Contrary to downregulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1, an upregulation of glial fibrillary acidic protein, a differentiation marker for astrocytic cells is observed. Ca2+, PKA, PI 3-K/PKB/GSK-3, Epac/Rap1/PP2A and MAP kinase modules are not involved in the inhibition of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene expression, overview | Rattus norvegicus |