Literature summary for 3.1.4.1 extracted from

Giachini, F.R.; Lima, V.V.; Carneiro, F.S.; Tostes, R.C.; Webb, R.C.
Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1 (2011), Hypertension, 57, 655-663.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male	-
Rattus norvegicus Sprague-Dawley	-	male	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	arteries from hypertensive rats, vascular PDE1A, PDE1B, PDE1C, and PDE5 isoforms	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PDE 1A	-	Rattus norvegicus
phosphodiesterase 1A	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	angiotensin II upregulates phosphodiesterase 1A expression	up

General Information

General Information	Comment	Organism
malfunction	phosphodiesterase-1 inhibition decreases vascular contraction in arteries from angiotensin II hypertensive, but not control, rats	Rattus norvegicus
physiological function	phosphodiesterase 1 plays a role in decreased cGMP level contributing to increased contraction in arteries from hypertensive rats. Ang II augments PDE1 activation, decreasing the bioavailability of cyclic guanosine 3',5'-monophosphate, and contributing to increased vascular contractility, effects of different PDF isozymes, overview	Rattus norvegicus

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Release 2023.1 (January 2023)