Information on EC 2.7.8.43 - lipid A phosphoethanolamine transferase

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EC Tree
IUBMB Comments
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
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Word Map
  • 2.7.8.43
  • colistin-resistant
  • plasmid-mediated
  • last-resort
  • last-line
  • kdo
  • 3-deoxy-d-manno-octulosonic
  • synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
A0R63_06305, Cj0256, colistin resistance PEtN transferase, EptA, EptAPa, EptC, ESA_RS09200, ethanolamine phosphotransferase, HD_0852, HMPREF2573_04170, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
show the reaction diagram
(3)
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diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
show the reaction diagram
(1)
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diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
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