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Information on EC 2.7.8.43 - lipid A phosphoethanolamine transferase
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2.7.8.43 lipid A phosphoethanolamine transferaseIUBMB Comments
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
phosphoethanolamine transferase, petn transferase, pea transferase, lipid a phosphoethanolamine transferase, cj0256, esa_rs09200, lipooligosaccharide phosphoethanolamine transferase a, hp0022, lpt-o, petn-transferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A0R63_06305
Cj0256
EC 2.7.4.30
-
-
formerly
-
EptA
EptC
ESA_RS09200
ethanolamine phosphotransferase
HD_0852
lipid A PEA transferase
lipid A phosphoethanolamine transferase
lipooligosaccharide phosphoethanolamine transferase A
LOS PEA transferase A
LptA
LptH
NMB1638
NmLptA
PEA transferase
PEA transferase A
PetL
pEtN transferase
phosphoethanolamine transferase
phosphoethanolamine transferase A
PmrA
PmrC
polymyxin resistance protein A
polymyxin resistance protein C
sNMLptA
lipid A PEA transferase
-
-
-
-
LptA
-
-
-
-
PmrA
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
(3)
-
-
-
diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
(1)
-
-
-
diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
(2)
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
diacylphosphatidylethanolamine:lipid-A phosphoethanolaminetransferase
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dihexanoyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
low activity, addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dihexanoyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
low activity, addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dioleoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dipalmitoyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dipalmitoyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dipalmitoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
diacylphosphatidylethanolamine + arbutin
diacylglycerol + ?
arbutin is a substrate for the phosphoethanolamine transferase
-
-
?
diacylphosphatidylethanolamine + lipid A
?
a phosphoethanolamine unit is directly linked to the 1-position of the disaccharide backbone of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + O-antigen serotype 4av
diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)
-
the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)
-
?
diacylphosphatidylethanolamine + O-antigen serotype Xv
diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + O-antigen serotype Yv
diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)
-
the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dioleoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
-
-
-
?
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dioleoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dipalmitoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
-
-
-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + monoolein
1,2-dipalmitoyl-sn-glycerol + 2-oleoyl-sn-glycero-1-phosphoethanolamine
-
-
-
?
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
-
-
?
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
1-acyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
-
-
?
diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
-
-
-
?
diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A
-
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
FlgG is modified at a single site Thr75, EptC is unable to modify other amino acids (e.g. serine and tyrosine), mass spectroscopic analysis, overview
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
usage of recombinant C-terminally His6-tagged substrate protein
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
EptC transfers phosphoethanolamine from the head groups of phosphatidylethanolamine onto Thr75 of FlgG proteins
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
FlgG is modified at a single site Thr75, EptC is unable to modify other amino acids (e.g. serine and tyrosine), mass spectroscopic analysis, overview
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
EptC transfers phosphoethanolamine from the head groups of phosphatidylethanolamine onto Thr75 of FlgG proteins
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
A0A3Z8TVG8
EptC transfers phosphoethanolamine from the head groups of phosphatidylethanolamine onto the LOS core and phosphates of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
A0A3Z8TVG8
EptC transfers phosphoethanolamine from the head groups of phosphatidylethanolamine onto the LOS core and phosphates of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
[Haemophilus] ducreyi ATCC 700724
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
A0A3Z8TVG8
EptC transfers phosphoethanolamine from the head groups of phosphatidylethanolamine onto the LOS core and phosphates of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
the phosphoethanolamine transferase is specific for the 4'-phosphate residue of Cronobacter sakazakii lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
the phosphoethanolamine transferase is specific for the 4'-phosphate residue of Cronobacter sakazakii lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
Pseudomonas aeruginosa lipid A, enzyme EptAPa-dependent addition of pEtN to the 4' phosphate group of BN2 and PA14 lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
[Haemophilus] ducreyi ATCC 700724
-
-
-
?
diacylphosphatidylethanolamine + O-antigen serotype Xv
diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)
-
the serotype Xv O-antigen has the phosphoethanolamine on RhaII, in serotype Yv, mono- and bisphosphorylated O-units generate a block-copolymeric structure, the former being partially O-acetylated at position 6 of GlcNAc and the latter lacking O-acetylation. The serotype Xv O-antigen has the phosphoethanolamine on RhaII
-
?
diacylphosphatidylethanolamine + O-antigen serotype Xv
diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)
-
-
in serotype Yv, mono- and bisphosphorylated O-units generate a block-copolymeric structure, the former being partially O-acetylated at position 6 of GlcNAc and the latter lacking O-acetylation. The serotype Xv O-antigen has the phosphoethanolamine on RhaII
-
?
additional information
?
-
addition of phosphoethanolamine to hepta-acylated lipid A
-
-
?
additional information
?
-
enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide
-
-
?
additional information
?
-
the lipid A of Campylobacter jejuni is characterized by longer secondary acyl chains attached to the 2' and 3' positions of the molecule and by the addition of phosphoethanolamine to the phosphate groups attached at the 1 and 4' positions of the disaccharide backbone. The disaccharide backbone of Campylobacter jejuni lipid A is not composed solely of glucosamine residues, but can be replaced with the analogue 2,3-diamino-2,3-dideoxy-D-glucopyranose
-
-
?
additional information
?
-
-
the lipid A of Campylobacter jejuni is characterized by longer secondary acyl chains attached to the 2' and 3' positions of the molecule and by the addition of phosphoethanolamine to the phosphate groups attached at the 1 and 4' positions of the disaccharide backbone. The disaccharide backbone of Campylobacter jejuni lipid A is not composed solely of glucosamine residues, but can be replaced with the analogue 2,3-diamino-2,3-dideoxy-D-glucopyranose
-
-
?
additional information
?
-
A0A3Z8TVG8
pEtN transferase, EptC, modifies an array of cell-surface molecules and the N-linked glycans of numerous glycoproteins
-
-
?
additional information
?
-
-
pEtN transferase, EptC, modifies an array of cell-surface molecules and the N-linked glycans of numerous glycoproteins
-
-
?
additional information
?
-
enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide
-
-
?
additional information
?
-
A0A3Z8TVG8
pEtN transferase, EptC, modifies an array of cell-surface molecules and the N-linked glycans of numerous glycoproteins
-
-
?
additional information
?
-
enzyme EptA or PmrC catalyses the periplasmic addition of the positively charged substituent phosphoethanolamine to lipid A controlled by the PmrA transcriptional regulator and conferring resistance to cationic antimicrobial peptides, including polymyxin
-
-
?
additional information
?
-
the phosphoethanolamine cycle, overview
-
-
?
additional information
?
-
quantitative analysis of binding of LPS by LptA, 1:1 ratio for the LPS:LptA complex, and structure analysis of the LPS binding pocket. The entire LptA protein is affected by LPS binding, the N-terminus unfolds in the presence of LPS
-
-
?
additional information
?
-
specific LPS interactions with LptA and LptC
-
-
?
additional information
?
-
transfer may occur both to the 4'- and 1-phospho groups of lipid A
-
-
-
additional information
?
-
lipid A of Helicobacter pylori lacks a 4'-phosphate group and is tri- or tetra-acylated with either (R)-3-hydroxystearate (C18) or (R)-3-hydroxypalmitate (C16), the C-1 hydroxyl group of the proximal glucosamine is derivatized with a phosphoethanolamine residue. This is in contrast with the phoshoethanolamine units of Escherichia coli, Salmonella typhimurium, and Neisseria meningitidis, which are attached to the lipid A phosphate group to form a pyrophosphate linkage. A minor lipid A species found in Helicobacter pylori is both bisphosphorylated and hexa-acylated resembling enterobacterial lipid As
-
-
?
additional information
?
-
-
lipid A of Helicobacter pylori lacks a 4'-phosphate group and is tri- or tetra-acylated with either (R)-3-hydroxystearate (C18) or (R)-3-hydroxypalmitate (C16), the C-1 hydroxyl group of the proximal glucosamine is derivatized with a phosphoethanolamine residue. This is in contrast with the phoshoethanolamine units of Escherichia coli, Salmonella typhimurium, and Neisseria meningitidis, which are attached to the lipid A phosphate group to form a pyrophosphate linkage. A minor lipid A species found in Helicobacter pylori is both bisphosphorylated and hexa-acylated resembling enterobacterial lipid As
-
-
?
additional information
?
-
-
phosphoethanolamine substitution at both the 1 and 4' positions of lipid A, component of lipooligosaccharide. Lipooligosaccharide structure analysis by MALDI-TOF mass spectrometry, overview
-
-
?
additional information
?
-
-
phosphoethanolamine substitution at both the 1 and 4' positions of lipid A, component of lipooligosaccharide. Lipooligosaccharide structure analysis by MALDI-TOF mass spectrometry, overview
-
-
?
additional information
?
-
in all meningococcal strains examined, each lipid A species contains the basal diphosphorylated species, wherein a phosphate group is attached to each glucosamine residue. Also elaborated within the population of lipopolysacchride molecules are a variety of phosphoforms that contain either an additional phosphate residue, an additional phosphoethanolamine residue, additional phosphate and phosphoethanolamine residues, or an additional phosphate and two phosphoethanolamine residues in the lipid A, mass spectroscopic analyses, overview
-
-
?
additional information
?
-
-
in all meningococcal strains examined, each lipid A species contains the basal diphosphorylated species, wherein a phosphate group is attached to each glucosamine residue. Also elaborated within the population of lipopolysacchride molecules are a variety of phosphoforms that contain either an additional phosphate residue, an additional phosphoethanolamine residue, additional phosphate and phosphoethanolamine residues, or an additional phosphate and two phosphoethanolamine residues in the lipid A, mass spectroscopic analyses, overview
-
-
?
additional information
?
-
in Neisseria meningitidis, phosphatidylethanolamine typically has acyl chains of C12 and C14 with the first position being occupied with a saturated chain and the second being unsaturated. The recombinant soluble periplasmic domain of the enzyme is active in an aqueous assay but unable to add phoshoethanolamine to lipid A in Escherichia coli strains, lipid A profiles, overview
-
-
?
additional information
?
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in Neisseria meningitidis, phosphatidylethanolamine typically has acyl chains of C12 and C14 with the first position being occupied with a saturated chain and the second being unsaturated. The recombinant soluble periplasmic domain of the enzyme is active in an aqueous assay but unable to add phoshoethanolamine to lipid A in Escherichia coli strains, lipid A profiles, overview
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?
additional information
?
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in Neisseria meningitidis, phosphatidylethanolamine typically has acyl chains of C12 and C14 with the first position being occupied with a saturated chain and the second being unsaturated. The recombinant soluble periplasmic domain of the enzyme is active in an aqueous assay but unable to add phoshoethanolamine to lipid A in Escherichia coli strains, lipid A profiles, overview
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?
additional information
?
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enzyme activity assays on the membrane-deleted LptA are performed using 4-nitrophenyl phosphoethanolamine, p-NPPE, as the substrate analogue, the enzyme is capable of cleaving the phosphoethanolamine portion from the p-NPPE chromogenic substrate
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additional information
?
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enzyme activity assays on the membrane-deleted LptA are performed using 4-nitrophenyl phosphoethanolamine, p-NPPE, as the substrate analogue, the enzyme is capable of cleaving the phosphoethanolamine portion from the p-NPPE chromogenic substrate
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?
additional information
?
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enzyme activity assays on the membrane-deleted LptA are performed using 4-nitrophenyl phosphoethanolamine, p-NPPE, as the substrate analogue, the enzyme is capable of cleaving the phosphoethanolamine portion from the p-NPPE chromogenic substrate
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?
additional information
?
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enzyme activity assays on the membrane-deleted LptA are performed using 4-nitrophenyl phosphoethanolamine, p-NPPE, as the substrate analogue, the enzyme is capable of cleaving the phosphoethanolamine portion from the p-NPPE chromogenic substrate
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?
additional information
?
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enzyme EptA catalyses the periplasmic addition of the positively charged substituent phosphoethanolamine to lipid A controlled by the PmrA transcriptional regulator and conferring resistance to cationic antimicrobial peptides, including polymyxin
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?
additional information
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enzyme EptA catalyses the periplasmic addition of the positively charged substituent phosphoethanolamine to lipid A controlled by the PmrA transcriptional regulator and conferring resistance to cationic antimicrobial peptides, including polymyxin
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?
additional information
?
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the enzyme modifies lipid A with one or two phosphoethanolamine moieties. Six lipid A substrate subtypes, St1 to St6, from wild type Salmonella typhimurium are covalently modified with one or two 4-amino-4-deoxy-L-arabinose moieties. Each lipid A species with a defined set of polar modifications can be further derivatized with a palmitoyl moiety and/or a 2-hydroxymyristoyl residue in place of the secondary myristoyl chain at position 3', high resolution NMR spectroscopy and mass spectrometry analysis of lipid A profiles from wild-type strain 14028 and mutant strains, overview
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additional information
?
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the enzyme modifies lipid A with one or two phosphoethanolamine moieties. Six lipid A substrate subtypes, St1 to St6, from wild type Salmonella typhimurium are covalently modified with one or two 4-amino-4-deoxy-L-arabinose moieties. Each lipid A species with a defined set of polar modifications can be further derivatized with a palmitoyl moiety and/or a 2-hydroxymyristoyl residue in place of the secondary myristoyl chain at position 3', high resolution NMR spectroscopy and mass spectrometry analysis of lipid A profiles from wild-type strain 14028 and mutant strains, overview
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?
additional information
?
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lipid A substrate and product analysis by MALDI-TOF/MS. The lipidA preparations from transgenic Escherichia coli strains carrying EptA show additional ions due to the addition of phosphoethanolamine to the bis-phosphorylatedstructure and the hepta-acylated structure
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?
additional information
?
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lipid A substrate and product analysis by MALDI-TOF/MS. The lipidA preparations from transgenic Escherichia coli strains carrying EptA show additional ions due to the addition of phosphoethanolamine to the bis-phosphorylatedstructure and the hepta-acylated structure
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additional information
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NMR spectroscopic analysis of O-antigen substrates and products, detailed overview
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?
additional information
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NMR spectroscopic analysis of O-antigen substrates and products, detailed overview
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?
additional information
?
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enzyme LptA modifies lipid A with phosphoethanolamine, mass spectrometric analysis. Haemophilus ducreyi lipopolysaccharide contains one phosphoethanolamine on its lipid A and one phosphoethanolamine on its core oligosaccharide
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additional information
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enzyme LptA modifies lipid A with phosphoethanolamine, mass spectrometric analysis. Haemophilus ducreyi lipopolysaccharide contains one phosphoethanolamine on its lipid A and one phosphoethanolamine on its core oligosaccharide
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dipalmitoyl-sn-glycerol + lipid A 1-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A
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-
?
1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine + lipid A
1,2-dipalmitoyl-sn-glycerol + lipid A 4'-(2-aminoethyl diphosphate)
addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A
-
-
?
diacylphosphatidylethanolamine + lipid A
?
a phosphoethanolamine unit is directly linked to the 1-position of the disaccharide backbone of lipid A
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-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
diacylphosphatidylethanolamine + O-antigen serotype 4av
diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)
-
the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)
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?
diacylphosphatidylethanolamine + O-antigen serotype Xv
diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)
-
the serotype Xv O-antigen has the phosphoethanolamine on RhaII
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?
diacylphosphatidylethanolamine + O-antigen serotype Yv
diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)
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the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)
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?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
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-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
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-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
-
-
-
?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
?
A0A3Z8TVG8
-
-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
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-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A (2-aminoethyl diphosphate)
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-
-
?
diacylphosphatidylethanolamine + lipid A
diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)