Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | Q8Z1P4 | serovar Typhimurium, gene pmrA | - |
Salmonella enterica 14028s | Q8Z1P4 | serovar Typhimurium, gene pmrA | - |
Synonyms | Comment | Organism |
---|---|---|
PmrA | - |
Salmonella enterica |
General Information | Comment | Organism |
---|---|---|
malfunction | phenotypes of mutants of PmrA-dependent genes pbgE2 and pbgE3, overview | Salmonella enterica |
metabolism | under PmrA regulator activation, the expression of wzzfepE and wzzst genes is induced, and their products are required to determine the O-antigen chain length. Wzzst protein is necessary to maintain the balance of 4-aminoarabinose and phosphoethanolamine lipid A modifications. The interaction of the PmrA-dependent pbgE2 and pbgE3 gene products is important for the formation of the short O-antigen region, protein Wzzst is unable to interact with itself or with the PbgE2 or PbgE3 protein | Salmonella enterica |
physiological function | PmrAB is the global regulatory system that controls lipopolysaccharide modification, leading to a coordinate regulation of 4-aminoarabinose incorporation and O-antigen chain length to respond against the host defense mechanisms. The PmrAB two-component system consists of the PmrA response regulator and the PmrB sensor, which is able to sense Fe3+, activating the system. The PmrAB two-component system activation promotes a remodeling of lipid A and the core region by addition of 4-aminoarabinose and/or phosphoethanolamine. These PmrA-dependent activities are produced by activation of ugd, pbgPE, pmrC, cpta, and pmrG transcription. Lipid A profiles from wild-type and mutant strains, overview | Salmonella enterica |