Ligand lipid A

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Basic Ligand Information

Molecular Structure
Picture of lipid A (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C97H184N2O25P2
lipid A
ZZGOUPTUJNOGBQ-APIRGGAJSA-N
Synonyms:
hexa-acyl lipid A

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A = 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
show the reaction diagram
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lipid A + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid A + CMP
show the reaction diagram
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ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
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ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
lipid A + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid A + CMP
show the reaction diagram
-
lipid A = ?
show the reaction diagram
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-
ATP + H2O + Lipid A/in = ADP + phosphate + Lipid A/out
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
about 2fold stimulation of the ATPase activity of MsbA by its substrate
-
stimulates ATPase activity
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
translocation of NBD-phosphatidylethanolamine is inhibited by the presence of the putative physiological substrate lipid A, probably due to competition for flipping of 7-nitrobenz-2-oxa-1,3-diazole-labeled phosphoethanolamine (NBD-PE)
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lipid A inhibits translocation by approx. 30% at 0.01-0.04 mg/ml
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0064
-
pH 7.5, 37°C, recombinant His-tagged enzyme

References & Links

Links to other databases for lipid A

ChEBI
PubChem
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PubChem