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Literature summary for 2.7.8.43 extracted from

  • Cullen, T.W.; Madsen, J.A.; Ivanov, P.L.; Brodbelt, J.S
    Trent, M.S.: Characterization of unique modification of flagellar rod protein FlgG by Campylobacter jejuni lipid A phosphoethanolamine transferase, linking bacterial locomotion and antimicrobial peptide resistance (2012), J. Biol. Chem., 287, 326-3336.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylphosphatidylethanolamine + flagellar rod protein FlgG Campylobacter jejuni
-
 ?
-
 ?
diacylphosphatidylethanolamine + flagellar rod protein FlgG Campylobacter jejuni 81-176
-
 ?
-
 ?
diacylphosphatidylethanolamine + lipid A Campylobacter jejuni
-
 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Campylobacter jejuni
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Campylobacter jejuni 81-176
-
 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A Campylobacter jejuni 81-176
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni A0A3X8T8A0 gene cj0256 or eptC
-
Campylobacter jejuni 81-176 A0A3X8T8A0 gene cj0256 or eptC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylphosphatidylethanolamine + flagellar rod protein FlgG
-
 Campylobacter jejuni ?
-
 ?
diacylphosphatidylethanolamine + flagellar rod protein FlgG FlgG is modified at a single site Thr75, EptC is unable to modify other amino acids (e.g. serine and tyrosine), mass spectroscopic analysis, overview Campylobacter jejuni ?
-
 ?
diacylphosphatidylethanolamine + flagellar rod protein FlgG
-
 Campylobacter jejuni 81-176 ?
-
 ?
diacylphosphatidylethanolamine + flagellar rod protein FlgG FlgG is modified at a single site Thr75, EptC is unable to modify other amino acids (e.g. serine and tyrosine), mass spectroscopic analysis, overview Campylobacter jejuni 81-176 ?
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni 81-176 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni 81-176 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Synonyms

Synonyms Comment Organism
Cj0256
-
 Campylobacter jejuni
EptC
-
 Campylobacter jejuni
pEtN transferase
-
 Campylobacter jejuni
phosphoethanolamine transferase
-
 Campylobacter jejuni

General Information

General Information Comment Organism
malfunction the eptC-deficient Campylobacter jejuni strain shows a dramatic decrease in resistance to polymyxin B when compared with wild-type, indicating a loss of phosphoethanolamine modification of the lipid A backbone. Campylobacter strains expressing site-directed FlgG mutants show defects in motility arise directly from the loss of phophoethanolamine modification of FlgG, phenotypes, overview Campylobacter jejuni
physiological function the enzyme EptC serves a dual role in modifying the flagellar rod protein, FlgG, and the lipid A domain lipooligosaccharide with a pEtN residue Campylobacter jejuni