Literature summary for 2.7.8.43 extracted from

Sun, J.; Xu, Y.; Gao, R.; Lin, J.; Wei, W.; Srinivas, S.; Li, D.; Yang, R.-S.; Li, X.-P.; Liao, X.-P.; Liu, Y.-H.; Feng, Y.
Deciphering MCR-2 colistin resistance (2017), mBio, 8, e00625 .

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Protein Variants

Protein Variants	Comment	Organism
D463A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli
E244A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli
H393A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli
H464A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli
H476A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli
additional information	domain swapping between isoforms Mcr1 and Mcr2 shows that the presence of the resultant two chimeric genes can confer resistance of the colistin-susceptible strain MG1655 to up to 16 mg/liter of colistin	Escherichia coli
T283A	mutant cannot confer robust growth to the recipient strain in presence of more than 2 mg/liter of colistin	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	A0A1C3NEV1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diacylphosphatidylethanolamine + lipid A	-	Escherichia coli	diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)	-	?

Synonyms

Synonyms	Comment	Organism
MCR2	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	a 6-residue-requiring zinc-binding/catalytic motif is essential for MCR2-mediated colistin resistance. The transmembrane regions TM2 and TM1 play a critical role in MCR2-mediated colistin resistance, catalytic activity depends on the correct location of MCR2 in bacterial periplasm	Escherichia coli

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Release 2023.1 (January 2023)