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Literature summary for 2.7.8.43 extracted from
- Modification of lipooligosaccharide with phosphoethanolamine by LptA in Neisseria meningitidis enhances meningococcal adhesion to human endothelial and epithelial cells (2008), Infect. Immun., 76, 5777-5789.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene lptA, expression from a a multicopy plasmid in Neisseria meningitidis, construction of an lptA-FLAG epitope-tagged fusion Neisseria meningitidis strain HT1295 from strain H44/76 | Neisseria meningitidis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diacylphosphatidylethanolamine + lipid A | Neisseria meningitidis | addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A | diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate) | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Neisseria meningitidis | X5ELY0 | diverse strains, gene lptA | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diacylphosphatidylethanolamine + lipid A | addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A | Neisseria meningitidis | diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LptA | - |
Neisseria meningitidis |
| PEA transferase | - |
Neisseria meningitidis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disruption of gene lptA leads to a approximately 10fold decrease in Neisseria meningitidis adhesion to four kinds of human endothelial and epithelial cell lines. Complementation with the lptA gene in the DELTAlptA mutant restores wild-type adherence | Neisseria meningitidis |
| physiological function | modification of lipooligosaccharide with phosphoethanolamine by enzyme LptA enhances meningococcal adhesion to human endothelial and epithelial cells in unencapsulated Neisseria meningitidis. LptA does not directly act as an adhesin molecule. Enzyme LptA-mediated adhesion may be masked when meningococci are encapsulated | Neisseria meningitidis |
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