Reference on EC 2.7.8.43 - lipid A phosphoethanolamine transferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Herrera, C.M.; Hankins, J.V.; Trent, M.S.
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides
Mol. Microbiol.
76
1444-1460
2010
Escherichia coli (P30845), Salmonella enterica (P36555), Salmonella enterica LT2 (P36555)
Anandan, A.; Piek, S.; Kahler, C.; Vrielink, A.
Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis
Acta Crystallogr. Sect. F
68
1494-1497
2012
Neisseria meningitidis (Q7DDQ9), Neisseria meningitidis, Neisseria meningitidis NMB (Q7DDQ9)
Beceiro, A.; Llobet, E.; Aranda, J.; Bengoechea, J.A.; Doumith, M.; Hornsey, M.; Dhanji, H.; Chart, H.; Bou, G.; Livermore, D.M.; Woodford, N.
Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system
Antimicrob. Agents Chemother.
55
3370-3379
2011
Acinetobacter baumannii (E2FGC2)
Handing, J.W.; Criss, A.K.
The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils
Cell. Microbiol.
17
910-921
2015
Neisseria gonorrhoeae (Q5F6F3), Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090 (Q5F6F3)
Takahashi, H.; Carlson, R.W.; Muszynski, A.; Choudhury, B.; Kim, K.S.; Stephens, D.S.; Watanabe, H.
Modification of lipooligosaccharide with phosphoethanolamine by LptA in Neisseria meningitidis enhances meningococcal adhesion to human endothelial and epithelial cells
Infect. Immun.
76
5777-5789
2008
Neisseria meningitidis (X5ELY0), Neisseria meningitidis
Lewis, L.A.; Choudhury, B.; Balthazar, J.T.; Martin, L.E.; Ram, S.; Rice, P.A.; Stephens, D.S.; Carlson, R.; Shafer, W.M.
Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum
Infect. Immun.
77
1112-1120
2009
Neisseria gonorrhoeae, Neisseria gonorrhoeae FA19
Lewis, L.A.; Shafer, W.M.; Dutta Ray, T.; Ram, S.; Rice, P.A.
Phosphoethanolamine residues on the lipid A moiety of Neisseria gonorrhoeae lipooligosaccharide modulate binding of complement inhibitors and resistance to complement killing
Infect. Immun.
81
33-42
2013
Neisseria gonorrhoeae
Cullen, T.W.; O'Brien, O.P.; Hendrixson, D.R.; Giles, D.K.; Hobb, R.I.; Thompson, S.A.; Brodbelt, J.S.; Trent, M.S.
EptC of Campylobacter jejuni mediates phenotypes involved in host interactions and virulence
Infect. Immun.
81
430-4440
2013
Campylobacter jejuni (A0A3X8T8A0), Campylobacter jejuni 81-176 (A0A3X8T8A0)
Cox, A.D.; Wright, J.C.; Li, J.; Hood, D.W.; Moxon, E.R.; Richards, J.C.
Phosphorylation of the lipid A region of meningococcal lipopolysaccharide: identification of a family of transferases that add phosphoethanolamine to lipopolysaccharide
J. Bacteriol.
185
3270-3277
2003
Neisseria meningitidis (X5ELY0), Neisseria meningitidis
Lee, H.; Hsu, F.F.; Turk, J.; Groisman, E.A.
The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica
J. Bacteriol.
186
4124-4133
2004
Salmonella enterica (Q8Z1P4)
Tamayo, R.; Choudhury, B.; Septer, A.; Merighi, M.; Carlson, R.; Gunn, J.S.
Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core
J. Bacteriol.
187
3391-3399
2005
Salmonella enterica (P36555), Salmonella enterica (Q8Z1P4), Salmonella enterica LT2 (P36555), Salmonella enterica LT2 (Q8Z1P4)
Zhou, Z.; Ribeiro, A.A.; Lin, S.; Cotter, R.J.; Miller, S.I.; Raetz, C.R.
Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation
J. Biol. Chem.
276
43111-43121
2001
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028
Tran, A.X.; Karbarz, M.J.; Wang, X.; Raetz, C.R.H.; McGrath, S.C.; Cotter, R.J.; Trent, M.S.
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A
J. Biol. Chem.
279
55780-55791
2004
Helicobacter pylori (O24867), Helicobacter pylori
Tran, A.X.; Lester, M.E.; Stead, C.M.; Raetz, C.R.; Maskell, D.J.; McGrath, S.C.; Cotter, R.J.; Trent, M.S.
Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A
J. Biol. Chem.
280
28186-28194
2005
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium C5
Cullen, T.W.; Madsen, J.A.; Ivanov, P.L.; Brodbelt, J.S
Trent, M.S.: Characterization of unique modification of flagellar rod protein FlgG by Campylobacter jejuni lipid A phosphoethanolamine transferase, linking bacterial locomotion and antimicrobial peptide resistance
J. Biol. Chem.
287
326-3336
2012
Campylobacter jejuni (A0A3X8T8A0), Campylobacter jejuni, Campylobacter jejuni 81-176 (A0A3X8T8A0)
Farizano, J.V.; Pescaretti, M.d.e..L.; Lopez, F.E.; Hsu, F.F.; Delgado, M.A.
The PmrAB system-inducing conditions control both lipid A remodeling and O-antigen length distribution, influencing the Salmonella typhimurium-host interactions
J. Biol. Chem.
287
38778-38789
2012
Salmonella enterica (Q8Z1P4), Salmonella enterica 14028s (Q8Z1P4)
Wanty, C.; Anandan, A.; Piek, S.; Walshe, J.; Ganguly, J.; Carlson, R.W.; Stubbs, K.A.; Kahler, C.M.; Vrielink, A.
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin
J. Mol. Biol.
425
3389-3402
2013
Neisseria meningitidis (Q7DD94), Neisseria meningitidis (Q7DDQ9), Neisseria meningitidis, Neisseria meningitidis NMB (Q7DDQ9)
Gunn, J.S.; Lim, K.B.; Krueger, J.; Kim, K.; Guo, L.; Hackett, M.; Miller, S.I.
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance
Mol. Microbiol.
27
1171-1182
1998
Salmonella enterica (Q8Z1P4), Salmonella enterica 14028s (Q8Z1P4)
Trombley, M.P.; Post, D.M.; Rinker, S.D.; Reinders, L.M.; Fortney, K.R.; Zwickl, B.W.; Janowicz, D.M.; Baye, F.M.; Katz, B.P.; Spinola, S.M.; Bauer, M.E.
Phosphoethanolamine transferase LptA in Haemophilus ducreyi modifies lipid A and contributes to human defensin resistance in vitro
PLoS ONE
10
e0124373
2015
[Haemophilus] ducreyi, [Haemophilus] ducreyi (Q7VMW0), [Haemophilus] ducreyi ATCC 700724 (Q7VMW0)
Cullen, T.; Trent, M.
A link between the assembly of flagella and lipooligosaccharide of the gram-negative bacterium Campylobacter jejuni
Proc. Natl. Acad. Sci. USA
107
5160-5165
2010
Campylobacter jejuni (A0A3X8T8A0), Campylobacter jejuni
Packiam, M.; Yedery, R.D.; Begum, A.A.; Carlson, R.W.; Ganguly, J.; Sempowski, G.D.; Ventevogel, M.S.; Shafer, W.M.; Jerse, A.E.
Phosphoethanolamine decoration of Neisseria gonorrhoeae lipid A plays a dual immunostimulatory and protective role during experimental genital tract infection
Infect. Immun.
82
2170-2179
2014
Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090
Liu, L.; Li, Y.; Wang, X.; Guo, W.
A phosphoethanolamine transferase specific for the 4'-phosphate residue of Cronobacter sakazakii lipid A
J. Appl. Microbiol.
121
1444-1456
2016
Cronobacter sakazakii (A7MFE0), Cronobacter sakazakii, Cronobacter sakazakii BAA894 (A7MFE0)
Nowicki, E.M.; OBrien, J.P.; Brodbelt, J.S.; Trent, M.S.
Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system
Mol. Microbiol.
97
166-178
2015
Pseudomonas aeruginosa (A0A069Q704), Pseudomonas aeruginosa
Piek, S.; Wang, Z.; Ganguly, J.; Lakey, A.M.; Bartley, S.N.; Mowlaboccus, S.; Anandan, A.; Stubbs, K.A.; Scanlon, M.J.; Vrielink, A.; Azadi, P.; Carlson, R.W.; Kahler, C.M.
The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin
PLoS ONE
9
e106513
2014
Neisseria meningitidis (Q7DDQ9), Neisseria meningitidis, Neisseria meningitidis NMB (Q7DDQ9)
Fage, C.D.; Brown, D.B.; Boll, J.M.; Keatinge-Clay, A.T.; Trent, M.S.
Crystallographic study of the phosphoethanolamine transferase EptC required for polymyxin resistance and motility in Campylobacter jejuni
Acta Crystallogr. Sect. D
70
2730-2739
2014
Campylobacter jejuni (A0A3Z8TVG8), Campylobacter jejuni, Campylobacter jejuni 81-176 (A0A3Z8TVG8)
Bontemps-Gallo, S.; Cogez, V.; Robbe-Masselot, C.; Quintard, K.; Dondeyne, J.; Madec, E.; Lacroix, J.M.
Biosynthesis of osmoregulated periplasmic glucans in Escherichia coli: the phosphoethanolamine transferase is encoded by opgE
BioMed Res. Int.
2013
371429
2013
Escherichia coli (P75785), Escherichia coli
Knirel, Y.A.; Lan, R.; Senchenkova, S.N.; Wang, J.; Shashkov, A.S.; Wang, Y.; Perepelov, A.V.; Xiong, Y.; Xu, J.; Sun, Q.
O-antigen structure of Shigella flexneri serotype Yv and effect of the lpt-O gene variation on phosphoethanolamine modification of S. flexneri O-antigens
Glycobiology
23
475-485
2013
Shigella flexneri (S4UV19), Shigella flexneri
Telke, A.A.; Rolain, J.M.
Functional genomics to discover antibiotic resistance genes: the paradigm of resistance to colistin mediated by ethanolamine phosphotransferase in Shewanella algae MARS 14
Int. J. Antimicrob. Agents
46
648-652
2015
Shewanella algae (A0A0H5BY27), Shewanella algae MARS 14 (A0A0H5BY27)
Hicks, G.; Jia, Z.
Structural basis for the lipopolysaccharide export activity of the bacterial lipopolysaccharide transport system
Int. J. Mol. Sci.
19
E2680
2018
Escherichia coli (P0ADV1)
Sherman, D.J.; Lazarus, M.B.; Murphy, L.; Liu, C.; Walker, S.; Ruiz, N.; Kahne, D.
Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport
Proc. Natl. Acad. Sci. USA
111
4982-4987
2014
Neisseria meningitidis serogroup B (Q7DDQ9), Neisseria meningitidis serogroup B MC58 (Q7DDQ9)
Schultz, K.M.; Lundquist, T.J.; Klug, C.S.
Lipopolysaccharide binding to the periplasmic protein LptA
Protein Sci.
26
1517-1523
2017
Escherichia coli (P0ADV1)
Stogios, P.J.; Cox, G.; Zubyk, H.L.; Evdokimova, E.; Wawrzak, Z.; Wright, G.D.; Savchenko, A.
Substrate recognition by a colistin resistance enzyme from Moraxella catarrhalis
ACS Chem. Biol.
13
1322-1332
2018
Moraxella sp. HMSC061H09 (A0A1E9VP98)
Stojanoski, V.; Sankaran, B.; Prasad, B.V.V.; Poirel, L.; Nordmann, P.; Palzkill, T.
Structure of the catalytic domain of the colistin resistance enzyme MCR-1
BMC Biol.
14
81
2016
Escherichia coli (A0A0R6L508)
Harper, M.; Wright, A.; Michael, F.; Li, J.; Lucas, D.; Ford, M.; Adler, B.; Cox, A.; Boyce, J.
Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2
Infect. Immun.
85
e00557
2017
Pasteurella multocida, Pasteurella multocida X73
Liu, L.; Li, Y.; Wang, X.; Guo, W.
A phosphoethanolamine transferase specific for the 4-phosphate residue of Cronobacter sakazakii lipid A
J. Appl. Microbiol.
121
1444-1456
2016
Cronobacter sakazakii, Cronobacter sakazakii BAA894
Sun, J.; Xu, Y.; Gao, R.; Lin, J.; Wei, W.; Srinivas, S.; Li, D.; Yang, R.-S.; Li, X.-P.; Liao, X.-P.; Liu, Y.-H.; Feng, Y.
Deciphering MCR-2 colistin resistance
mBio
8
e00625
2017
Escherichia coli (A0A1C3NEV1)
Anandan, A.; Evans, G.L.; Condic-Jurkic, K.; OMara, M.L.; John, C.M.; Phillips, N.J.; Jarvis, G.A.; Wills, S.S.; Stubbs, K.A.; Moraes, I.; Kahler, C.M.; Vrielink, A.
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding
Proc. Natl. Acad. Sci. USA
114
2218-2223
2017
Neisseria meningitidis serogroup B (Q7DD94), Neisseria meningitidis serogroup B MC58 (Q7DD94)
Jo, S.; Park, H.; Song, W.; Kim, S.; Kim, E.; Yang, Y.; Kim, J.; Kim, B.; Kim, Y.
Structural characterization of phosphoethanolamine-modified lipid A from probiotic Escherichia coli strain Nissle 1917
RSC Adv.
9
19762-19771
2019
Escherichia coli, Escherichia coli Nissle 1917
-
van t Hag, L.; Anandan, A.; Seabrook, S.A.; Gras, S.L.; Drummond, C.J.; Vrielink, A.; Conn, C.E.
Direct demonstration of lipid phosphorylation in the lipid bilayer of the biomimetic bicontinuous cubic phase using the confined enzyme lipid A phosphoethanolamine transferase
Soft Matter
13
1493-1504
2017
Neisseria meningitidis serogroup B (Q7DD94), Neisseria meningitidis serogroup B MC58 (Q7DD94)
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