Ligand diacylglycerol

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Basic Ligand Information

Molecular Structure
Picture of diacylglycerol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H18O5R2
diacylglycerol
LEIGXIGLVRJIMR-SECBINFHSA-N
Synonyms:
1,2 diglycerides, 1,2-diacyl-sn-glycerol, 1,2-diacyl-sn-glycerols, 1,2-diacylglycerol, 1,2-sn-diacylglycerol, 2,3-diacylglycerol, a 1,2-diacyl-sn-glycerol, D-1,2-diacylglycerol, diacyl-sn-glycerol, diglyceride, sn-1,2-diacylglycerol, sn-1,2-diacylglycerol', syn-1,2-diacylglycerol
Pathway Source
Pathways
KEGG
Adipocytokine signaling pathway, Adrenergic signaling in cardiomyocytes, African trypanosomiasis, AGE-RAGE signaling pathway in diabetic complications, Aldosterone synthesis and secretion more


Show all pahtways known for Show all BRENDA pathways known for diacylglycerol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
show the reaction diagram
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UDP-glucose + 1,2-diacyl-sn-glycerol = UDP + 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol
show the reaction diagram
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UDPglucose + 1,2-diacylglycerol = UDP + 3-D-glucosyl-1,2-diacylglycerol
show the reaction diagram
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CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate
show the reaction diagram
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ATP + diacylglycerol = ADP + phosphatidic acid
show the reaction diagram
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diacylglycerol + H2O = monoacylglycerol + a carboxylate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + 2-monoacylglycerol = CoA + diacylglycerol
show the reaction diagram
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1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 1,2-diacyl-sn-glycerol
show the reaction diagram
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phosphatidylglycerol + membrane-derived oligosaccharide D-glucose = sn-1,2-diacylglycerol + beta-D-glucoside-6-phosphoglycerol
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
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phosphatidylcholine + H2O = diacylglycerol + phosphorylcholine
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
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phosphatidylethanolamine + H2O = diacylglycerol + ethanolamine phosphate
show the reaction diagram
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6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (77 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
show the reaction diagram
-
UDP-alpha-D-glucose + 1,2-diacyl-sn-glycerol = 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP
show the reaction diagram
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ATP + diacylglycerol = ADP + diacylglycerol 1-phosphate
show the reaction diagram
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ATP + diacylglycerol = ADP + phosphatidic acid
show the reaction diagram
-
sphingomyelin + diacylglycerol = ceramide + phosphatidylcholine
show the reaction diagram
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diacylglycerol + H2O = ?
show the reaction diagram
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diacylglycerol + H2O = monoacylglycerol + a carboxylate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (111 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acyl-CoA + 2-monoacylglycerol = CoA + diacylglycerol
show the reaction diagram
-
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1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + 1,2-diacyl-sn-glycerol
show the reaction diagram
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phosphatidylcholine + CMP = CDP-choline + diacylglycerol
show the reaction diagram
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CMP + phosphatidylcholine = CDP-choline + 1,2-diacylglycerol
show the reaction diagram
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a ceramide + a phosphatidylethanolamine = a ceramide phosphoethanolamine + a 1,2-diacyl-sn-glycerol
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + carboxylic acid
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
-
phosphatidylcholine + H2O = diacylglycerol + phosphorylcholine
show the reaction diagram
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triacylglycerol + H2O = diacylglycerol + a carboxylate
show the reaction diagram
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phosphatidylinositol + H2O = diacylglycerol + inositol phosphate
show the reaction diagram
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monogalactosyldiacylglycerol + H2O = galactose + diacylglycerol
show the reaction diagram
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phosphoinositide + H2O = inositol phosphate + diacylglycerol
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulated by exogenous 1,2-diacylglycerols, largest stimulation by 1,2-diolein and 1,2-diacylglycerol
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exogenous diacylglycerol stimulates GIVA PLA2-mediated arachidonic acid release
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interaction of phospholipase D with the lipidic activator at the air-water interface
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Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
only slight depression
-
dicaprin, dimyristin, dipalmitin, high concentration
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with saturated fatty acids
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above 3.4 mol%, substrate inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.13
-
donor UDP-alpha-D-galactose, pH 8.0, 28°C

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.27
-
donor UDP-alpha-D-galactose, pH 8.0, 28°C
0.25
-
pH 7.5, 25°C
0.063
-
30°C, pH 8.0
0.112
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-

References & Links

Links to other databases for diacylglycerol

ChEBI
PubChem
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PubChem