BRENDA - Reference to 2.7.8.43; Id = 740516

gene lpt-O

Shigella flexneri

diacylphosphatidylethanolamine + O-antigen serotype 4av

Shigella flexneri

-

diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)

the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

Shigella flexneri

-

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

the serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Yv

Shigella flexneri

-

diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)

the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

Shigella flexneri

S4UV19

several different strains

-

diacylphosphatidylethanolamine + O-antigen serotype 4av

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)

the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

the serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

in serotype Yv, mono- and bisphosphorylated O-units generate a block-copolymeric structure, the former being partially O-acetylated at position 6 of GlcNAc and the latter lacking O-acetylation. The serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Yv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)

the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

additional information

NMR spectroscopic analysis of O-antigen substrates and products, detailed overview

740516

Shigella flexneri

?

-

gene lpt-O

Shigella flexneri

diacylphosphatidylethanolamine + O-antigen serotype 4av

Shigella flexneri

-

diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)

the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

Shigella flexneri

-

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

the serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Yv

Shigella flexneri

-

diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)

the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

diacylphosphatidylethanolamine + O-antigen serotype 4av

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype 4av (2-aminoethyl diphosphate)

the serotype 4av O-antigen has the phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

the serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Xv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Xv (2-aminoethyl diphosphate)

in serotype Yv, mono- and bisphosphorylated O-units generate a block-copolymeric structure, the former being partially O-acetylated at position 6 of GlcNAc and the latter lacking O-acetylation. The serotype Xv O-antigen has the phosphoethanolamine on RhaII

-

?

diacylphosphatidylethanolamine + O-antigen serotype Yv

-

740516

Shigella flexneri

diacylglycerol + O-antigen serotype Yv 3-(2-aminoethyl diphosphate)

the serotype Yv O-antigen has the same basic carbohydrate backbone structure as that of the classical serotype Y, but differs in the presence of phosphoethanolamine at position 3 of RhaIII (major) or both RhaII and RhaIII (minor)

-

?

additional information

NMR spectroscopic analysis of O-antigen substrates and products, detailed overview

740516

Shigella flexneri

?

-

physiological function

in Shigella flexneri serotype X and 4a variants called Xv and 4av, respectively, O-antigen modification with phosphoethanolamine (PEtN) is identified, which is encoded by a plasmid-borne gene lpt-O for a PEtN-transferase and confers the monoclonal antibody IV-1(MASF IV-1) determinant to the bacteria. A correlation between the serotype-specific PEtN modification pattern and the lpt-O variation in different serotypes: lpt-ORII in serotype Xv is better tuned for phosphorylation of RhaII and lpt-ORIII in serotypes Yv and 4av for phosphorylation of RhaII

Shigella flexneri

physiological function

in Shigella flexneri serotype X and 4a variants called Xv and 4av, respectively, O-antigen modification with phosphoethanolamine (PEtN) is identified, which is encoded by a plasmid-borne gene lpt-O for a PEtN-transferase and confers the monoclonal antibody IV-1(MASF IV-1) determinant to the bacteria. A correlation between the serotype-specific PEtN modification pattern and the lpt-O variation in different serotypes: lpt-ORII in serotype Xv is better tuned for phosphorylation of RhaII and lpt-ORIII in serotypes Yv and 4av for phosphorylation of RhaII

Shigella flexneri

750867

Hicks

-

Structural basis for the lipo ...

Escherichia coli

Int. J. Mol. Sci.

19

E2680

2018

-

1

-

1

-

1

-

1

-

1

-

1

-

752134

Schultz

Lipopolysaccharide binding to ...

Escherichia coli

Protein Sci.

26

1517-1523

2017

-

1

-

14

-

1

-

1

-

1

-

1

-

1

-

14

-

1

-

1

-

1

-

3

-

738476

Liu

A phosphoethanolamine transfer ...

Cronobacter sakazakii, Cronobacter sakazakii BAA894

J. Appl. Microbiol.

121

1444-1456

2016

-

1

-

1

-

2

-

4

-

2

-

1

-

1

-

2

-

2

-

2

-

733635

Handing

The lipooligosaccharide-modify ...

Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090

Cell. Microbiol.

17

910-921

2015

-

1

-

1

-

2

-

4

-

2

-

1

-

1

-

2

-

2

-

2

-

735018

Trombley

Phosphoethanolamine transferas ...

Haemophilus ducreyi, Haemophilus ducreyi ATCC 700724

PLoS ONE

10

e0124373

2015

-

1

-

1

-

1

-

7

-

5

-

2

-

1

-

1

-

5

-

2

3

-

739106

Nowicki

Extracellular zinc induces pho ...

Pseudomonas aeruginosa

Mol. Microbiol.

97

166-178

2015

-

1

-

1

-

1

-

1

-

4

-

2

-

1

-

1

-

1

-

1

-

2

-

1

2

1

-

740532

Telke

Functional genomics to discove ...

Shewanella algae, Shewanella algae MARS 14

Int. J. Antimicrob. Agents

46

648-652

2015

-

1

-

2

-

2

-

4

-

1

-

2

-

4

-

1

-

738368

Packiam

Phosphoethanolamine decoration ...

Neisseria gonorrhoeae, Neisseria gonorrhoeae FA 1090

Infect. Immun.

82

2170-2179

2014

-

1

-

2

-

11

-

2

-

1

-

2

-

2

-

2

-

739495

Piek

The role of oxidoreductases in ...

Neisseria meningitidis, Neisseria meningitidis NMB

PLoS ONE

9

e106513

2014

1

-

1

-

1

-

1

-

1

-

8

-

1

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

1

-

739786

Fage

Crystallographic study of the ...

Campylobacter jejuni, Campylobacter jejuni 81-176

Acta Crystallogr. Sect. D

70

2730-2739

2014

-

1

6

-

1

7

-

3

-

1

-

12

2

-

1

-

1

6

-

1

7

-

1

-

12

2

-

3

-

752031

Sherman

Decoupling catalytic activity ...

Neisseria meningitidis serogroup B, Neisseria meningitidis serogroup B MC58

Proc. Natl. Acad. Sci. USA

111

4982-4987

2014

-

1

-

2

-

1

-

2

-

733965

Lewis

Phosphoethanolamine residues o ...

Neisseria gonorrhoeae

Infect. Immun.

81

33-42

2013

-

1

-

2

-

733966

Cullen

EptC of Campylobacter jejuni m ...

Campylobacter jejuni, Campylobacter jejuni 81-176

Infect. Immun.

81

430-4440

2013

-

1

-

1

-

8

-

3

-

8

-

1

-

1

-

8

-

8

-

2

-

734476

Wanty

The structure of the neisseria ...

Neisseria meningitidis, Neisseria meningitidis NMB

J. Mol. Biol.

425

3389-3402

2013

-

1

-

1

-

3

-

6

-

8

-

1

-

12

1

-

2

-

1

-

1

-

5

-

6

-

1

-

12

1

-

3

4

-

740134

Bontemps-Gallo

Biosynthesis of osmoregulated ...

Escherichia coli

BioMed Res. Int.

2013

371429

2013

1

-

1

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

740516

Knirel

O-antigen structure of Shigell ...

Shigella flexneri

Glycobiology

23

475-485

2013

-

1

-

3

-

4

-

5

-

1

-

3

-

5

-

1

-

733017

Anandan

Cloning, expression, purificat ...

Neisseria meningitidis, Neisseria meningitidis NMB

Acta Crystallogr. Sect. F

68

1494-1497

2012

-

1

-

1

-

7

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

734190

Cullen

Trent, M.S.: Characterization ...

Campylobacter jejuni, Campylobacter jejuni 81-176

J. Biol. Chem.

287

326-3336

2012

-

6

-

8

-

8

-

6

-

8

-

2

-

734198

Farizano

The PmrAB system-inducing cond ...

Salmonella enterica 14028s, Salmonella enterica

J. Biol. Chem.

287

38778-38789

2012

-

3

-

3

-

733107

Beceiro

Phosphoethanolamine modificati ...

Acinetobacter baumannii

Antimicrob. Agents Chemother.

55

3370-3379

2011

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

3

1

-

723212

Herrera

Activation of PmrA inhibits Lp ...

Escherichia coli, Salmonella enterica, Salmonella enterica LT2

Mol. Microbiol.

76

1444-1460

2010

1

-

2

-

2

1

-

4

-

3

-

1

-

2

-

2

1

-

3

-

2

5

2

-

735157

Cullen

A link between the assembly of ...

Campylobacter jejuni

Proc. Natl. Acad. Sci. USA

107

5160-5165

2010

-

1

-

1

-

1

-

4

-

3

-

5

-

1

-

1

-

1

-

4

-

5

-

2

-

733963

Lewis

Phosphoethanolamine substituti ...

Neisseria gonorrhoeae, Neisseria gonorrhoeae FA19

Infect. Immun.

77

1112-1120

2009

-

1

-

1

-

4

-

3

-

6

-

1

-

1

-

4

-

6

-

1

-

733962

Takahashi

Modification of lipooligosacch ...

Neisseria meningitidis

Infect. Immun.

76

5777-5789

2008

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

2

-

734067

Tamayo

Identification of cptA, a PmrA ...

Salmonella enterica, Salmonella enterica LT2

J. Bacteriol.

187

3391-3399

2005

-

1

-

4

-

5

-

4

-

2

-

4

-

4

-

2

4

-

734151

Tran

Resistance to the antimicrobia ...

Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium C5

J. Biol. Chem.

280

28186-28194

2005

-

1

-

3

-

1

-

5

-

734064

Lee

The PmrA-regulated pmrC gene m ...

Salmonella enterica

J. Bacteriol.

186

4124-4133

2004

1

-

1

-

1

-

3

-

734148

Tran

Periplasmic cleavage and modif ...

Helicobacter pylori

J. Biol. Chem.

279

55780-55791

2004

-

1

-

3

-

4

-

3

-

1

-

3

-

3

-

2

-

734062

Cox

Phosphorylation of the lipid A ...

Neisseria meningitidis

J. Bacteriol.

185

3270-3277

2003

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

2

-

734138

Zhou

Lipid A modifications in polym ...

Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028

J. Biol. Chem.

276

43111-43121

2001

-

1

-

2

-

3

-

2

-

1

-

2

-

2

-

1

-

734706

Gunn

PmrA-PmrB-regulated genes nece ...

Salmonella enterica 14028s, Salmonella enterica

Mol. Microbiol.

27

1171-1182

1998

-

1

-

3

-

1

-

2

-

O-antigen structure of Shigella flexneri serotype Yv and effect of the lpt-O gene variation on phosphoethanolamine modification of S. flexneri O-antigens

Data extracted from this reference: