Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria gonorrhoeae | - |
gene lptA | - |
Synonyms | Comment | Organism |
---|---|---|
LptA | - |
Neisseria gonorrhoeae |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of phosphoethanolamine from lipid A diminishes binding of the complement regulatory protein C4b binding protein (C4BP) to the FA19 porin B (PorB), providing a molecular basis to explain the susceptibility of an lptA null strain of FA19 to killing by normal human serum. Loss of phosphoethanolamine from lipid A also affects binding of the alternative pathway regulator factor H to PorB of some strains, e.g. strains 252 and 1291, but not of strains FA1090 and 273. Complementation of lptA null strains with lptA restores C4BP binding, decreased C4b deposition, and increased resistance to killing by normal human serum | Neisseria gonorrhoeae |
physiological function | phosphoethanolamine-lipid A contributes to serum resistance by modulating factor H binding | Neisseria gonorrhoeae |