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Information on EC 2.7.1.60 - N-acylmannosamine kinase
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EC Tree
2.7.1.60 N-acylmannosamine kinaseIUBMB Comments
Acts on the acetyl and glycolyl derivatives.
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Word Map
- 2.7.1.60
-
sialic
- myopathy
-
n-acetylneuraminic
-
2.7.1.59
-
sialylation
- glycoconjugates
-
rimmed
-
n-acetylmannosamine-6-phosphate
- n-acetyl-d-glucosamine
- glucokinase
-
nanks
-
aminosugars
- neu5ac
- medicine
- molecular biology
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
n-acetylmannosamine kinase, udp-n-acetylglucosamine-2-epimerase/n-acetylmannosamine-kinase, udp-glcnac 2-epimerase/mannac 6-kinase, n-acyl-d-mannosamine kinase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetylamidodeoxymannokinase
-
-
-
-
acetylmannosamine kinase
-
-
-
-
acylaminodeoxymannokinase
-
-
-
-
acylmannosamine kinase
-
-
-
-
acylmannosamine kinase (phosphorylating)
-
-
-
-
ATP:N-acetylmannosamine 6-phosphotransferase
-
-
-
-
EC 2.7.1.59/EC 2.7.1.60
-
bifunctional, N-acetylglucosamine kinase and N-acetylmannosamine kinase activity
EC 5.1.3.14/EC 2.7.1.60
GNE
ManAc kinase
MNK
N-acetylmannosamine kinase
N-acetylmannosamine-6-phosphate 2-epimerase
N-acyl-D-mannosamine kinase
-
-
-
-
nanK
UDP-GlcNAc 2-epimerase/ManNAc kinase
UDP-GlcNAc-epimerase/ManNAc kinase
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
GNE
bifunctional enzyme with UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities
N-acetylmannosamine kinase
-
-
-
-
N-acetylmannosamine kinase
bifunctional enzyme: UDP-N-acetylglucosamine 2-epimerase /N-acetylmannosamine kinase
UDP-GlcNAc-epimerase/ManNAc kinase
-
-
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
two different enzyme activities combined in a single bifunctional enzyme
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
two different enzyme activities combined in a single bifunctional enzyme
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
two different enzyme activities combined in a single bifunctional enzyme
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
two different enzyme activities combined in a single bifunctional enzyme
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
-
two different enzyme activities combined in a single bifunctional enzyme, N-terminal region is for epimerase activity, C-terminal region is for kinase activity
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate
acts on the acetyl and glycolyl derivatives
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:N-acyl-D-mannosamine 6-phosphotransferase
Acts on the acetyl and glycolyl derivatives.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9027-53-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
-
-
-
r
ATP + N-acetyl-D-glucosamine
ADP + N-acetyl-D-glucosamine 6-phosphate
Staphylococcus aureus PS 47
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
metabolic pathway between hexoses and sialic acids
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
highly specific for ATP and N-acetyl-D-mannosamine
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Staphylococcus aureus PS 47
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
highly specific for ATP and N-acetyl-D-mannosamine
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine-6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key and rate limiting enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, enzyme mutations can cause hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, mutations in the enzyme causes hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, reduced activity causes distal myopathy with rimmed vacuoles
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
isoform GNE2 displays an extended N-terminus compared with isoform GNE, which is linked directly to the epimerase domain. Recombinant GNE2 still possesses both enzymatic activities of GNE
-
-
?
additional information
?
-
isoform GNE3 displays an deleted N-terminus compared with isoform GNE. Recombinant GNE3 shows a total loss of the epimerase activity
-
-
?
additional information
?
-
the enzyme is a bifunctional enzyme uridine diphosphate 1-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, i.e. UDP-GlcNAc 2-epimerase/ManNAc kinase or GNE. The N-terminal domain carries out UDP-GlcNAc epimerase function, whereas the C-terminal domain is responsible for ManNAc kinase activity
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
displays N-acetylglucosamine kinase activity as well as N-acetylmannosamine kinase activity
-
-
?
additional information
?
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
D-glucose, D-mannose, N-acetyl-D-glucosamine and N-acetyl-D-galactosamine are not phosphorylated
-
-
?
additional information
?
-
-
N-acetylglucosamine and N-glycolylglucosamine, N-acetylgalactosamine, mannosamine, glucosamine, galactosamine, mannose, galactose, fructose, glucose, glucose-1-phosphate and glucose-6-phosphate are inactive as substrates, the phosphoryl donor ATP cannot be replaced by GTP, UTP, CTP, TTP, dATP or phosphoenolpyruvate
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis
-
-
?
additional information
?
-
-
glucose, mannose, fructose, glucosamine, N-acetylglucosamine and N-acetylgalactosamine are inactive as substrates
-
-
?
additional information
?
-
-
no enzyme found when bacteria grow in presence of glucose
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
the enzyme is a bifunctional enzyme uridine diphosphate 1-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, i.e. UDP-GlcNAc 2-epimerase/ManNAc kinase or GNE. The N-terminal domain carries out UDP-GlcNAc epimerase function, whereas the C-terminal domain is responsible for ManNAc kinase activity
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
metabolic pathway between hexoses and sialic acids
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
enzyme is involved in sialic acid metabolism
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
highly specific for ATP and N-acetyl-D-mannosamine
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
-
-
-
r
ATP + N-acetyl-D-mannosamine
ADP + N-acetyl-D-mannosamine 6-phosphate
Staphylococcus aureus PS 47
-
-
-
r
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key and rate limiting enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, enzyme mutations can cause hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, mutations in the enzyme causes hereditary inclusion body myopathy
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, reduced activity causes distal myopathy with rimmed vacuoles
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Co2+
Mg2+
Mn2+
additional information
Co2+
-
can replace Mg2+, but is less active
Mg2+
required, Mg2+ is octahedrically coordinated with the beta-phosphate-O3 atom and Asp-413-Odelta2 in the axial positions, whereas four water molecules occupy the equatorial sites
Mn2+
-
can replace Mg2+, but is less active
additional information
-
Ca2+, Ba2+, Cu2+, Fe2+, Sn2+ and Zn2+ shows no effect on enzyme activity, monovalent cations Li+, Na+, K+, Rb+ or Cs+ cannot replace Mg2+
additional information
-
Ca2+, Na+ and K+ have no effect
additional information
-
Ca2+, Na+ and K+ have no effect
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2Z)-1-(4-chlorophenyl)-3-(2-hydroxy-5-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
-
FMP-209613
(2Z)-3-(4-fluorophenyl)-1-(4-methylphenyl)-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-one
-
FMP-209617
1,3-dimethyl-4-(trifluoromethyl)-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one
-
-
4-(trifluoromethyl)pyridine-2-carboxylic acid
-
also named 4-(trifluoromethyl)picolinic acid
5-(anthracen-9-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
-
FMP-402534